World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
65
Citations
12505
World Ranking
7810
National Ranking
2277

Biology and Biochemistry

D-Index
67
Citations
12798
World Ranking
8375
National Ranking
3775

Overview

Jürgen Rohr is affiliated with the University of Kentucky in the United States. Their research spans various areas of biochemistry, genetics, molecular biology, and medicine, with a strong focus on cancer therapeutics and mechanisms as well as microbial natural products and fungal biology.

Their main fields of study include Biochemistry, Genetics and Molecular Biology with 20 publications, and Medicine with 18 publications. Within these fields, their work concentrates on subfields such as Molecular Biology, Pharmacology, Oncology, Cell Biology, and Organic Chemistry.

The topics covered in their research include:

  • Cancer therapeutics and mechanisms
  • Plant Pathogens and Fungal Diseases
  • Fungal Biology and Applications
  • Microbial Natural Products and Biosynthesis
  • DNA and Nucleic Acid Chemistry
  • Metal complexes synthesis and properties
  • Bioactive Compounds and Antitumor Agents

Jürgen Rohr has published in several peer-reviewed venues, frequently contributing to:

  • Frontiers in Microbiology
  • Cancer Research
  • Structure
  • Journal of Natural Products
  • Communications Chemistry

Recent notable papers include:

  1. Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens, 2021, Frontiers in Microbiology
  2. Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins, 2020, Structure
  3. Himalaquinones A-G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59, 2021, Journal of Natural Products
  4. Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy, 2020, Journal of Medicinal Chemistry
  5. Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer, 2021, Biomedicines

Their frequent co-authors are:

  • Jon S. Thorson
  • Oleg V. Tsodikov
  • Markos Leggas
  • Khaled A. Shaaban
  • Caixia Hou

Best Publications

  • Angucycline group antibiotics.

    J. Rohr;R. Thiericke

  • Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

    Madan K. Kharel;Pallab Pahari;Micah D. Shepherd;Nidhi Tibrewal

  • Combinatorial biosynthesis of antitumor indolocarbazole compounds

    César Sánchez;Lili Zhu;Alfredo F. Braña;Aaroa P. Salas

  • Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides

    Andreas Kirschning;Andreas F. W. Bechthold;Jürgen Rohr

  • The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin: Characterization and Generation of Indolocarbazole Derivatives

    César Sánchez;Igor A Butovich;Alfredo F Braña;Jürgen Rohr

  • Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

    Ernestina Fernández;Ulrike Weißbach;César Sánchez Reillo;Alfredo F. Braña

  • Modification of post-PKS tailoring steps through combinatorial biosynthesis.

    Unknown

  • ANGUCYCLINES : TOTAL SYNTHESES, NEW STRUCTURES, AND BIOSYNTHETIC STUDIES OF AN EMERGING NEW CLASS OF ANTIBIOTICS

    Karsten Krohn;Jürgen Rohr

  • An Audience Response System Strategy to Improve Student Motivation, Attention, and Feedback

    Jeff Cain;Esther P. Black;Jürgen Rohr

  • Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

    Lily L. Remsing;Ana M. González;Mohammad Nur-e-Alam;M. José Fernández-Lozano

  • METABOLIC PRODUCTS OF MICROORGANISMS. 234 URDAMYCINS, NEW ANGUCYCLINE ANTIBIOTICS FROM STREPTOMYCES FRADIAE

    Hannelore Drautz;Hans Zähner;Jürgen Rohr;Axel Zeeck

  • Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A-D.

    Thomas Henkel;Jürgen Rohr;John M. Beale;Ludger Schwenen

  • Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.

    Miranda Gibson;Mohammad Nur-e-alam;Fredilyn Lipata;Marcos A Oliveira

  • Arginine-rhamnosylation as new strategy to activate translation elongation factor P.

    Jürgen Lassak;Eva C Keilhauer;Maximilian Fürst;Kristin Wuichet

  • Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine : sugar donor substrate flexibility of the StaG glycosyltransferase

    Aaroa P. Salas;Lili Zhu;César Sánchez;Alfredo F. Braña

  • A New Role for Polyketides.

    Jürgen Rohr

  • Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues.

    Shanteri Singh;Jianjun Zhang;Tyler D. Huber;Manjula Sunkara

  • Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

    Sleiman Sf;Langley Bc;Basso M;Berlin J

  • The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.

    Carsten Fischer;Fredilyn Lipata;Jürgen Rohr

  • Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717.

    B. Faust;D. Hoffmeister;G. Weitnauer;L. Westrich

  • The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster

    D Hoffmeister;K Ichinose;S Domann;S Domann;B Faust

Frequent Co-Authors

José A. Salas
José A. Salas University of Oviedo
Carmen Méndez
Carmen Méndez University of Oviedo
Alfredo F. Braña
Alfredo F. Braña University of Oviedo
Axel Zeeck
Axel Zeeck University of Göttingen
Andreas Bechthold
Andreas Bechthold University of Freiburg
Jon S. Thorson
Jon S. Thorson University of Kentucky
George M. Sheldrick
George M. Sheldrick University of Göttingen
Hans Zähner
Hans Zähner University of Tübingen
Andreas Kirschning
Andreas Kirschning University of Hannover
Susan K. Buchanan
Susan K. Buchanan National Institutes of Health

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