His primary scientific interests are in Biochemistry, Biosynthesis, Gene, Gene cluster and Streptomyces albus. As part of his studies on Biochemistry, Alfredo F. Braña often connects relevant subjects like Stereochemistry. His Biosynthesis research is multidisciplinary, incorporating elements of Fermentation, Cyclase, Ammonium chloride, Ammonium and Isopenicillin N epimerase.
Alfredo F. Braña works mostly in the field of Gene, limiting it down to concerns involving Streptomyces and, occasionally, Mycelium and Substrate. He interconnects Regulator gene, Streptomyces griseus and Sequence analysis in the investigation of issues within Gene cluster. His study in Streptomyces albus is interdisciplinary in nature, drawing from both Indolocarbazole and Heterologous expression.
His primary scientific interests are in Biochemistry, Biosynthesis, Streptomyces, Gene and Gene cluster. Alfredo F. Braña has researched Biochemistry in several fields, including Stereochemistry and Streptomyces albus. The Stereochemistry study combines topics in areas such as Substrate and Aureolic acid.
The concepts of his Biosynthesis study are interwoven with issues in Glycosylation and Streptomyces griseus. His Streptomyces study incorporates themes from Botany, Enterobactin, Microbiology and Polysaccharide. He combines subjects such as Streptomyces cattleya, Thienamycin, Regulator gene and Sequence analysis with his study of Gene cluster.
Streptomyces, Biochemistry, Biosynthesis, Gene and Gene cluster are his primary areas of study. His Streptomyces research incorporates elements of Botany, Glycosyltransferase and Microbiology. Biochemistry and Streptomyces albus are commonly linked in his work.
The various areas that Alfredo F. Braña examines in his Biosynthesis study include Oxidoreductase, Oxazole, Thiazole, Stereochemistry and Leinamycin. His Gene study results in a more complete grasp of Genetics. In his study, Hypothetical protein is strongly linked to Polyketide, which falls under the umbrella field of Gene cluster.
His scientific interests lie mostly in Streptomyces, Gene, Gene cluster, Genome and Heterologous expression. His Streptomyces research integrates issues from Glycosyltransferase, Metabolic engineering, Pyruvate dehydrogenase complex and Enzyme. His studies deal with areas such as Structural similarity and DNA as well as Gene.
His study with Gene cluster involves better knowledge in Biochemistry. His research integrates issues of Regulation of gene expression, Regulator gene and Oligonucleotide in his study of Genome.
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Combinatorial biosynthesis of antitumor indolocarbazole compounds
César Sánchez;Lili Zhu;Alfredo F. Braña;Aaroa P. Salas.
Proceedings of the National Academy of Sciences of the United States of America (2005)
The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin: Characterization and Generation of Indolocarbazole Derivatives
César Sánchez;Igor A Butovich;Alfredo F Braña;Jürgen Rohr.
Chemistry & Biology (2002)
Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin
Ernestina Fernández;Ulrike Weißbach;César Sánchez Reillo;Alfredo F. Braña.
Journal of Bacteriology (1998)
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species
Felipe Lombó;Ana Velasco;Angelina Castro;Fernando de la Calle.
ChemBioChem (2006)
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
Lily L. Remsing;Ana M. González;Mohammad Nur-e-Alam;M. José Fernández-Lozano.
Journal of the American Chemical Society (2003)
Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055: Cluster Analysis and Assignment of Functions
Carlos Olano;Barrie Wilkinson;César Sánchez;Steven J Moss.
Chemistry & Biology (2004)
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
Carlos Olano;Ignacio García;Aranzazu González;Miriam Rodriguez.
Microbial Biotechnology (2014)
Engineering Deoxysugar Biosynthetic Pathways from Antibiotic-Producing Microorganisms: A Tool to Produce Novel Glycosylated Bioactive Compounds
Leticia Rodrı́guez;Ignacio Aguirrezabalaga;Nerea Allende;Alfredo F Braña.
Chemistry & Biology (2002)
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine : sugar donor substrate flexibility of the StaG glycosyltransferase
Aaroa P. Salas;Lili Zhu;César Sánchez;Alfredo F. Braña.
Molecular Microbiology (2005)
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.
César Sánchez;Alfredo F. Braña;Carmen Méndez;José A. Salas.
ChemBioChem (2006)
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