Alfredo F. Braña

Overview

Best Publications

• Combinatorial biosynthesis of antitumor indolocarbazole compounds

  César Sánchez;Lili Zhu;Alfredo F. Braña;Aaroa P. Salas

  302
  Citations

• The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin: Characterization and Generation of Indolocarbazole Derivatives

  César Sánchez;Igor A Butovich;Alfredo F Braña;Jürgen Rohr

  269
  Citations

• Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

  Ernestina Fernández;Ulrike Weißbach;César Sánchez Reillo;Alfredo F. Braña

  259
  Citations

• Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species

  Felipe Lombó;Ana Velasco;Angelina Castro;Fernando de la Calle

  240
  Citations

• Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074

  Carlos Olano;Ignacio García;Aranzazu González;Miriam Rodriguez

  239
  Citations

• Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

  Lily L. Remsing;Ana M. González;Mohammad Nur-e-Alam;M. José Fernández-Lozano

  187
  Citations

• Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055: Cluster Analysis and Assignment of Functions

  Carlos Olano;Barrie Wilkinson;César Sánchez;Steven J Moss

  185
  Citations

• Engineering Deoxysugar Biosynthetic Pathways from Antibiotic-Producing Microorganisms: A Tool to Produce Novel Glycosylated Bioactive Compounds

  Leticia Rodrı́guez;Ignacio Aguirrezabalaga;Nerea Allende;Alfredo F Braña

  177
  Citations

• Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.

  César Sánchez;Alfredo F. Braña;Carmen Méndez;José A. Salas

  158
  Citations

• Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine : sugar donor substrate flexibility of the StaG glycosyltransferase

  Aaroa P. Salas;Lili Zhu;César Sánchez;Alfredo F. Braña

  155
  Citations

• Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria.

  P Arca;M Rico;A F Braña;C J Villar

  145
  Citations

• The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

  Luz Elena Núñez;Carmen Méndez;Alfredo F Braña;Gloria Blanco

  145
  Citations

• Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

  Ignacio Aguirrezabalaga;Carlos Olano;Nerea Allende;Leticia Rodriguez

  141
  Citations

• Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs

  Nuria Menéndez;Mohammad Nur-e-Alam;Alfredo F. Braña;Jürgen Rohr

  131
  Citations

• Isolation, Characterization, and Heterologous Expression of the Biosynthesis Gene Cluster for the Antitumor Anthracycline Steffimycin

  Sonia Gullón;Carlos Olano;Mohamed S. Abdelfattah;Alfredo F. Braña

  128
  Citations

• Role of substrate mycelium in colony development in Streptomyces.

  Carmen Méndez;Alfredo F. Brana;Manuel B. Manzanal;Carlos Hardisson

  126
  Citations

• The Mithramycin Gene Cluster of Streptomyces argillaceus Contains a Positive Regulatory Gene and Two Repeated DNA Sequences That Are Located at Both Ends of the Cluster

  Felipe Lombó;Alfredo F. Braña;Carmen Méndez;José A. Salas

  123
  Citations

• Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

  Gloria Blanco;Eugenio P Patallo;Alfredo F Braña;Axel Trefzer

  123
  Citations

• Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.

  Axel Trefzer;Gloria Blanco;Lily Remsing;Eva Künzel

  121
  Citations

• Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

  Laura Prado;Ernestina Fernández;Ulrike Weiβbach;Gloria Blanco

  116
  Citations