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Chemistry

D-Index
80
Citations
19689
World Ranking
3488
National Ranking
195

Biology and Biochemistry

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80
Citations
20000
World Ranking
4151
National Ranking
310

Research.com Recognitions

  • 2000 - Fellow of the Royal Society, United Kingdom

Overview

Peter F. Leadlay is affiliated with the University of Cambridge in the United Kingdom, contributing to research primarily within the fields of Biochemistry, Genetics and Molecular Biology and Medicine. Their work spans several subfields including Molecular Biology, Pharmacology, Materials Chemistry, Organic Chemistry, and Plant Science.

The scientist has a prominent research focus on Microbial Natural Products and Biosynthesis, Genomics and Phylogenetic Studies, Enzyme Structure and Function, RNA and protein synthesis mechanisms, Carbohydrate Chemistry and Synthesis, Biochemical and Molecular Research, as well as Bacterial Genetics and Biotechnology.

Peter F. Leadlay's recent publications include the following papers:

  • Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase, 2020, Journal of Biological Chemistry
  • Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis, 2021, ACS Catalysis
  • The biosynthetic pathway to tetromadurin (SF2487/A80577), a polyether tetronate antibiotic, 2020, PLoS ONE
  • Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase, 2020, Angewandte Chemie International Edition
  • Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition, 2023, Nature Communications

Frequent co-authors in their research include:

  • Yuhui Sun
  • M.V.B. Dias
  • Fanglu Huang
  • Guo Sun
  • Priscila dos Santos Bury

The scientist's frequent publication venues reflect their research scope and include:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Catalysis
  • PLoS ONE
  • Nature Communications

Peter F. Leadlay has been recognized as a Fellow of the Royal Society, United Kingdom since 2000, indicating a notable standing within the scientific community.

Best Publications

  • An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

    Jesus Cortes;Stephen F. Haydock;Gareth A. Roberts;Debra J. Bevitt

  • Combinatorial biosynthesis of reduced polyketides

    Kira J. Weissman;Peter F. Leadlay

  • How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.

    Filippo Mancia;Nicholas H Keep;Atsushi Nakagawa;Peter F Leadlay

  • Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338

    Markiyan Oliynyk;Markiyan Samborskyy;John B Lester;Tatiana Mironenko

  • Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

    Timothy Paul Stinear;Armand Mve-Obiang;Pamela L C Small;Wafa Frigui

  • A chain initiation factor common to both modular and aromatic polyketide synthases

    Christian Bisang;Paul F. Long;Jesús Cortés;James Westcott

  • Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

    Jesus Cortes;Kirsten E. H. Wiesmann;Gareth A. Roberts;Murray J. B. Brown

  • Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

    Jesús F. Aparicio;István Molnár;Torsten Schwecke;Ariane König

  • Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase

    Andrew F. A. Marsden;Barrie Wilkinson;Jesús Cortés;Nicholas J. Dunster

  • Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

    Stephen F. Haydock;Jesús F. Aparicio;István Molnár;Torsten Schwecke

  • A hybrid modular polyketide synthase obtained by domain swapping.

    Markiyan Oliynyk;Murray J.B. Brown;Jesús Cortés;James Staunton

  • 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

    Debra J. Bevitt;Jesus Cortes;Stephen F. Haydock;Peter F. Leadlay

  • The structure of docking domains in modular polyketide synthases.

    R.William Broadhurst;Daniel Nietlispach;Michael P Wheatcroft;Peter F Leadlay

  • Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units.

    Michelle L Heathcote;James Staunton;Peter F Leadlay

  • Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.

    Stephen F. Haydock;James A. Dowson;Namrita Dhillon;Gareth A. Roberts

  • Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase

    Andrew F. A. Marsden;Patrick Caffrey;Jesus F. Aparicio;Mark S. Loughran

  • Increasing the efficiency of heterologous promoters in actinomycetes.

    Christopher J Wilkinson;Zoë A Hughes-Thomas;Christine J Martin;Ines Böhm

  • Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

    Markiyan Oliynyk;Christian B. W. Stark;Apoorva Bhatt;Michelle A. Jones

  • Combinatorial approaches to polyketide biosynthesis.

    Peter F Leadlay

  • Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.

    István Molnár;Jesús F. Aparicio;Stephen F. Haydock;Lake Ee Khaw

Frequent Co-Authors

James Staunton
James Staunton University of Cambridge
Barrie Wilkinson
Barrie Wilkinson John Innes Centre
Timothy P. Stinear
Timothy P. Stinear University of Melbourne
Zixin Deng
Zixin Deng Shanghai Jiao Tong University
Carmen Méndez
Carmen Méndez University of Oviedo
José A. Salas
José A. Salas University of Oviedo
Alfredo F. Braña
Alfredo F. Braña University of Oviedo
Caroline Demangel
Caroline Demangel Institut Pasteur
Ipsita Roy
Ipsita Roy University of Sheffield
Stewart T. Cole
Stewart T. Cole Institut Pasteur

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