D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 92 Citations 26,004 332 World Ranking 1067 National Ranking 458

Research.com Recognitions

Awards & Achievements

2013 - Fellow of the American Academy of Arts and Sciences

2003 - Fellow of the American Association for the Advancement of Science (AAAS)

1989 - Fellow of John Simon Guggenheim Memorial Foundation

1985 - Ernest Guenther Award, American Chemical Society (ACS)

1978 - Fellow of Alfred P. Sloan Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

His primary areas of investigation include Stereochemistry, Biochemistry, Biosynthesis, Polyketide and Polyketide synthase. The Stereochemistry study combines topics in areas such as Active site, ATP synthase, Enzyme, Protein structure and Acyl carrier protein. His work deals with themes such as Streptomycetaceae and Streptomyces, which intersect with Biochemistry.

His Biosynthesis research incorporates elements of Sesquiterpene and Antibacterial agent, Bacteria. Protein domain and Cell biology is closely connected to Protein engineering in his research, which is encompassed under the umbrella topic of Polyketide. David E. Cane combines subjects such as Lactone, Polyketide biosynthesis, Multifunctional Enzymes, Protein–protein interaction and Saccharopolyspora erythraea with his study of Polyketide synthase.

His most cited work include:

  • Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli (569 citations)
  • Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations (543 citations)
  • Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism (355 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Stereochemistry, Biochemistry, Biosynthesis, Polyketide and ATP synthase. David E. Cane interconnects Polyketide synthase and Active site, Substrate, Enzyme in the investigation of issues within Stereochemistry. Biochemistry and Streptomyces are commonly linked in his work.

His Biosynthesis research is multidisciplinary, incorporating perspectives in Bacteria, Streptomycetaceae, Actinomycetales and Pyrophosphate. His Polyketide study combines topics in areas such as Protein structure, Thioester, Protein engineering and Acyl carrier protein. The ATP synthase study combines topics in areas such as Streptomyces coelicolor, Recombinant DNA and Stereoisomerism.

He most often published in these fields:

  • Stereochemistry (72.14%)
  • Biochemistry (40.11%)
  • Biosynthesis (33.98%)

What were the highlights of his more recent work (between 2009-2018)?

  • Stereochemistry (72.14%)
  • Biochemistry (40.11%)
  • ATP synthase (22.01%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Stereochemistry, Biochemistry, ATP synthase, Polyketide and Polyketide synthase. His work carried out in the field of Stereochemistry brings together such families of science as Stereoisomerism, Lyase, Active site, Substrate and Acyl carrier protein. His study focuses on the intersection of Biochemistry and fields such as Streptomyces with connections in the field of Heterologous expression, Gene and Complementation.

His ATP synthase research incorporates elements of Sesquiterpene, Streptomyces coelicolor, Transferase and Terpenoid. In the field of Polyketide, his study on 6-Deoxyerythronolide B synthase overlaps with subjects such as Assembly line. His Polyketide synthase study integrates concerns from other disciplines, such as Molecular recognition, Nonribosomal peptide and Docking.

Between 2009 and 2018, his most popular works were:

  • Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism (355 citations)
  • Terpene synthases are widely distributed in bacteria (235 citations)
  • Engineered Streptomyces Avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites (149 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

David E. Cane mostly deals with Stereochemistry, Biochemistry, ATP synthase, Polyketide and Streptomyces. His Stereochemistry study focuses on Natural product in particular. His Biochemistry study focuses mostly on Biosynthesis, Protein structure, Terpene, Terpenoid and Monooxygenase.

His ATP synthase research includes elements of Protein engineering, Acyl carrier protein and Stereoisomerism. In general Polyketide study, his work on Polyketide synthase and 6-Deoxyerythronolide B synthase often relates to the realm of Assembly line and Mechanism, thereby connecting several areas of interest. His Streptomyces study combines topics in areas such as Heterologous expression and Escherichia coli.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

Blaine A. Pfeifer;Suzanne J. Admiraal;Hugo Gramajo;David E. Cane.
Science (2001)

872 Citations

Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations

David E. Cane;Christopher T. Walsh;Chaitan Khosla.
Science (1998)

843 Citations

Enzymic formation of sesquiterpenes

David E. Cane.
Chemical Reviews (1990)

575 Citations

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

Mamoru Komatsu;Takuma Uchiyama;Satoshi Omura;David E. Cane.
Proceedings of the National Academy of Sciences of the United States of America (2010)

541 Citations

Crystal structure of pentalenene synthase: Mechanistic insights on terpenoid cyclization reactions in biology

Charles A. Lesburg;Guangzhi Zhai;Guangzhi Zhai;David E. Cane;David E. Cane;David W. Christianson;David W. Christianson.
Science (1997)

487 Citations

TOLERANCE AND SPECIFICITY OF POLYKETIDE SYNTHASES

Chaitan Khosla;Rajesh S. Gokhale;John R. Jacobsen;David E. Cane.
Annual Review of Biochemistry (1999)

465 Citations

Dissecting and exploiting intermodular communication in polyketide synthases.

Rajesh S. Gokhale;Stuart Y. Tsuji;David E. Cane;Chaitan Khosla.
Science (1999)

413 Citations

Terpene synthases are widely distributed in bacteria

Yuuki Yamada;Tomohisa Kuzuyama;Mamoru Komatsu;Kazuo Shin-ya.
Proceedings of the National Academy of Sciences of the United States of America (2015)

389 Citations

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.

David E Cane;Christopher T Walsh.
Chemistry & Biology (1999)

384 Citations

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

John R. Jacobsen;C. Richard Hutchinson;David E. Cane;Chaitan Khosla.
Science (1997)

373 Citations

If you think any of the details on this page are incorrect, let us know.

Contact us

Best Scientists Citing David E. Cane

Jeroen S. Dickschat

Jeroen S. Dickschat

University of Bonn

Publications: 124

David H. Sherman

David H. Sherman

University of Michigan–Ann Arbor

Publications: 111

Chaitan Khosla

Chaitan Khosla

Stanford University

Publications: 100

Rodney Croteau

Rodney Croteau

Washington State University

Publications: 95

Peter F. Leadlay

Peter F. Leadlay

University of Cambridge

Publications: 94

Christopher T. Walsh

Christopher T. Walsh

Stanford University

Publications: 77

Jay D. Keasling

Jay D. Keasling

University of California, Berkeley

Publications: 76

Rolf Müller

Rolf Müller

Saarland University

Publications: 65

Christian Hertweck

Christian Hertweck

Friedrich Schiller University Jena

Publications: 63

Zixin Deng

Zixin Deng

Shanghai Jiao Tong University

Publications: 63

Dean J. Tantillo

Dean J. Tantillo

University of California, Davis

Publications: 61

Haruo Ikeda

Haruo Ikeda

Kitasato University

Publications: 59

James Staunton

James Staunton

University of Cambridge

Publications: 58

Bradley S. Moore

Bradley S. Moore

University of California, San Diego

Publications: 58

Ben Shen

Ben Shen

Scripps Research Institute

Publications: 53

Yi Tang

Yi Tang

University of California, Los Angeles

Publications: 50

Trending Scientists

Hervé Bourlard

Hervé Bourlard

Idiap Research Institute

Tom Kompas

Tom Kompas

University of Melbourne

Yannis Marinakis

Yannis Marinakis

Technical University of Crete

Lisbeth M. Ottosen

Lisbeth M. Ottosen

Technical University of Denmark

Seo Young Jeong

Seo Young Jeong

Kyung Hee University

Christoph Lengauer

Christoph Lengauer

Johns Hopkins University

Junhong Bai

Junhong Bai

Beijing Normal University

William J. Sydeman

William J. Sydeman

Farallon Institute

Christophe Beloin

Christophe Beloin

Institut Pasteur

Andrew P. Negri

Andrew P. Negri

Australian Institute of Marine Science

Claudio Latorre

Claudio Latorre

Pontificia Universidad Católica de Chile

Jerry M. Bigham

Jerry M. Bigham

The Ohio State University

Leo Peichl

Leo Peichl

Max Planck Society

Marie H. Monfils

Marie H. Monfils

The University of Texas at Austin

Kazuyoshi Takeda

Kazuyoshi Takeda

Juntendo University

Daniel F. Hayes

Daniel F. Hayes

University of Michigan–Ann Arbor

Something went wrong. Please try again later.