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D-Index & Metrics

Chemistry

D-Index
114
Citations
38162
World Ranking
685
National Ranking
281

Biology and Biochemistry

D-Index
117
Citations
43125
World Ranking
730
National Ranking
464

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2009 - Member of the National Academy of Engineering For engineering molecular assembly lines, developing metabolic engineering technologies, and advancing biopharmaceutical discovery.
  • 2007 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - ACS Award in Pure Chemistry, American Chemical Society (ACS)

Overview

Chaitan Khosla is affiliated with Stanford University in the United States. Their research is concentrated in the intersecting fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a specialized focus on Molecular Biology, Pharmacology, Infectious Diseases, Gastroenterology, and Immunology.

Their scholarly output includes significant contributions to topics such as Microbial Natural Products and Biosynthesis, Celiac Disease Research and Management, SARS-CoV-2 and COVID-19 Research, Genomics and Phylogenetic Studies, COVID-19 Clinical Research Studies, Plant biochemistry and biosynthesis, and Galectins and Cancer Biology.

Frequent publication venues for Khosla's research comprise:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Chemical Society
  • Biochemistry
  • Gastroenterology
  • Journal of Biological Chemistry

Collaborations with other researchers occur regularly, notably with Yvonne Maldonado, Upinder Singh, Prasanna Jagannathan, Julie Parsonnet, and Jason R. Andrews.

Some notable recent papers authored or co-authored by Khosla include:

  • "KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19" (2022) published in Science
  • "IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease" (2020) published in Nature
  • "Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial" (2021) published in Nature Communications
  • "Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity" (2022) published in Science Translational Medicine
  • "Prospects for Antibacterial Discovery and Development" (2021) published in Journal of the American Chemical Society

Khosla's work has been recognized with several awards, including election as a Member of the National Academy of Sciences in 2020 and a Member of the National Academy of Engineering in 2009 for engineering molecular assembly lines, developing metabolic engineering technologies, and advancing biopharmaceutical discovery.

Additional honors include being named a Fellow of the American Academy of Arts and Sciences in 2007, a Fellow of the American Association for the Advancement of Science (AAAS) in 2006, and receipt of the ACS Award in Pure Chemistry from the American Chemical Society in 2000.

Best Publications

  • Structural Basis for Gluten Intolerance in Celiac Sprue

    Lu Shan;Øyvind Molberg;Isabelle Parrot;Felix Hausch

  • A new enzyme superfamily — the phosphopantetheinyl transferases

    Ralph H. Lambalot;Amy M. Gehring;Roger S. Flugel;Peter Zuber

  • Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

    Blaine A. Pfeifer;Suzanne J. Admiraal;Hugo Gramajo;David E. Cane

  • Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations

    David E. Cane;Christopher T. Walsh;Chaitan Khosla

  • Engineered biosynthesis of novel polyketides

    Robert McDaniel;Susanne Ebert-Khosla;David A. Hopwood;Chaitan Khosla

  • Cloning and Heterologous Expression of the Epothilone Gene Cluster

    Li Tang;Sanjay Shah;Loleta Chung;John Carney

  • Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

    Daniel M Pinkas;Pavel Strop;Axel T Brunger;Chaitan Khosla

  • Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

    Chu Young Kim;Hanne Quarsten;Elin Bergseng;Chaitan Khosla

  • Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

    Romain Bouziat;Reinhard Hinterleitner;Judy J. Brown;Jennifer E. Stencel-Baerenwald

  • Overproduction of free fatty acids in E. coli: implications for biodiesel production.

    Xuefeng Lu;Harmit Vora;Chaitan Khosla

  • TOLERANCE AND SPECIFICITY OF POLYKETIDE SYNTHASES

    Chaitan Khosla;Rajesh S. Gokhale;John R. Jacobsen;David E. Cane

  • Intestinal digestive resistance of immunodominant gliadin peptides

    Felix Hausch;Lu Shan;Nilda A Santiago;Gary M Gray

  • Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.

    Christopher T. Walsh;Robert V. O'Brien;Chaitan Khosla

  • Dissecting and exploiting intermodular communication in polyketide synthases.

    Rajesh S. Gokhale;Stuart Y. Tsuji;David E. Cane;Chaitan Khosla

  • Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.

    John R. Jacobsen;C. Richard Hutchinson;David E. Cane;Chaitan Khosla

  • Biosynthesis of Polyketides in Heterologous Hosts

    Blaine A. Pfeifer;Chaitan Khosla

  • Identification and Analysis of Multivalent Proteolytically Resistant Peptides from Gluten: Implications for Celiac Sprue

    Lu Shan;Shuo-Wang Qiao;Helene Arentz-Hansen;Øyvind Molberg

  • Structure and Mechanism of the 6-Deoxyerythronolide B Synthase

    Chaitan Khosla;Yinyan Tang;Alice Y. Chen;Nathan A. Schnarr

  • Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

    Robert McDaniel;Susanne Ebert-Khosla;David A. Hopwood;Chaitan Khosla

  • The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase

    Yinyan Tang;Chu-Young Kim;Irimpan I. Mathews;David E. Cane

  • Engineered biosynthesis of a complete macrolactone in a heterologous host

    Camilla M. Kao;Leonard Katz;Chaitan Khosla

Frequent Co-Authors

David E. Cane
David E. Cane Brown University
David A. Hopwood
David A. Hopwood John Innes Centre
Ludvig M. Sollid
Ludvig M. Sollid Oslo University Hospital
Christopher T. Walsh
Christopher T. Walsh Stanford University
Daniel V. Santi
Daniel V. Santi University of California, San Francisco
Yi Tang
Yi Tang University of California, Los Angeles
Leonard Katz
Leonard Katz Haskins Laboratories
Michael C. Bassik
Michael C. Bassik Stanford University
Robert M. Stroud
Robert M. Stroud University of California, San Francisco

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