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Immunology

D-Index
80
Citations
24663
World Ranking
1618
National Ranking
62

Overview

Frits Koning is affiliated with Leiden University Medical Center in the Netherlands. Their research activity spans several interconnected fields, with a focus on Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. These broad disciplines reflect a multidisciplinary approach to biomedical research.

Their subfields of study include Immunology, Molecular Biology, Plant Science, Surgery, and Genetics. This diversity indicates a wide scope of interest and expertise across both basic and applied biomedical sciences.

Koning's main research topics cover a range of areas including:

  • Genetically Modified Organisms Research
  • Celiac Disease Research and Management
  • Reproductive System and Pregnancy
  • Immune Cell Function and Interaction
  • Single-cell and spatial transcriptomics
  • T-cell and B-cell Immunology
  • Pregnancy and preeclampsia studies

Their recent publications illustrate key themes in immunology and disease, including:

  • γδ T cells are effectors of immunotherapy in cancers with HLA class I defects, 2023, Nature
  • Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies, 2020, Frontiers in Oncology
  • Helminth infections drive heterogeneity in human type 2 and regulatory cells, 2020, Science Translational Medicine
  • Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity, 2020, Frontiers in Nutrition
  • Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease, 2021, Frontiers in Genetics

Koning has frequently co-published with several collaborators including F. Javier Moreno, Albert Braeuning, M. Epstein, Jean-Luc Gallois, and Alan H. Schulman. These partnerships suggest active engagement in collaborative research projects across various institutions or disciplines.

Their publications often appear in certain specialized venues that align with their fields of study, highlighting areas of repeated focus. These journals include:

  • EFSA Journal
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Reproductive Immunology
  • Journal of Crohn's and Colitis

Best Publications

  • The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase.

    Helene Arentz-Hansen;Roman Körner;Øyvind Molberg;Hanne Quarsten

  • Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes

    Teun W J M van Herpen;Svetlana V Goryunova;Svetlana V Goryunova;Johanna van der Schoot;Makedonka Mitreva;Makedonka Mitreva

  • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

    Marjolijn Duijvestein;Anne Christine W Vos;Helene Roelofs;Manon E Wildenberg

  • Isolation of CD4 - CD8 - mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

    Joseph Holoshttz;Samuel Strober;Frits Koning;John E. Coligan

  • The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

    Willemijn Vader;Yvonne Kooy;Peter van Veelen;Arnoud de Ru

  • Randomized Feeding Intervention in Infants at High Risk for Celiac Disease

    S. L. Vriezinga;R. Auricchio;E. Bravi;G. Castillejo

  • Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.

    Claudio L. A. Bassetti;Antoine Adamantidis;Denis Burdakov;Denis Burdakov;Denis Burdakov;Fang Han

  • Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease

    L. Willemijn Vader;Arnoud de Ru;Yvonne van der Wal;Yvonne M.C. Kooy

  • Identification of a Graft-versus-Host Disease-associated human minor Histocompatibility antigen.

    Joke M. M. den Haan;Nicholas E. Sherman;Els Blokland;Eric Huczko

  • Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.

    Ludvig M. Sollid;Shuo-Wang Qiao;Robert P. Anderson;Carmen Gianfrani

  • The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses

    Willemijn Vader;Dariusz Stepniak;Yvonne Kooy;Luisa Mearin

  • MANNOSE RECEPTOR-MEDIATED UPTAKE OF ANTIGENS STRONGLY ENHANCES HLA CLASS II-RESTRICTED ANTIGEN PRESENTATION BY CULTURED DENDRITIC CELLS

    M. C. A. A. Tan;A. M. Mommaas;J. W. Drijfhout;R. Jordens

  • Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease

    Dariusz Stepniak;Liesbeth Spaenij-Dekking;Cristina Mitea;Martine Moester

  • The Molecular Basis for Oat Intolerance in Patients with Celiac Disease

    Helene Arentz-Hansen;Burkhard Fleckenstein;Burkhard Fleckenstein;Øyvind Molberg;Helge Scott

  • γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

    Unknown

  • Characterization of cereal toxicity for celiac disease patients based on protein homology in grains.

    L.Willemijn Vader;Dariusz T Stepniak;Evelien M Bunnik;Yvonne M.C Kooy

  • T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

    Andrew J. Leishman;Olga V. Naidenko;Antoine Attinger;Frits Koning;Frits Koning

  • Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients

    Liesbeth Spaenij–Dekking;Yvonne Kooy–Winkelaar;Peter van Veelen;Jan Wouter Drijfhout

  • Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

    Yvonne van de Wal;Yvonne M. C. Kooy;Peter A. van Veelen;Salvador A. Peña

  • Glutenin is involved in the gluten-driven mucosal T cell response.

    Yvonne van de Wal;Yvonne M. C. Kooy;Peter van Veelen;Willemijn Vader

  • Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell

    Yvonne van de Wal;Yvonne Kooy;Peter van Veelen;Luisa Mearin

Frequent Co-Authors

Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Boudewijn P. F. Lelieveldt
Boudewijn P. F. Lelieveldt Leiden University Medical Center
Jamie Rossjohn
Jamie Rossjohn Monash University
Ludvig M. Sollid
Ludvig M. Sollid Oslo University Hospital
Chris J. J. Mulder
Chris J. J. Mulder Amsterdam UMC
Ronald E. Bontrop
Ronald E. Bontrop Utrecht University
Marinus J. M. Smulders
Marinus J. M. Smulders Wageningen University & Research
Tom H. M. Ottenhoff
Tom H. M. Ottenhoff Leiden University Medical Center
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

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