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Immunology

D-Index
96
Citations
32239
World Ranking
864
National Ranking
28

Medicine

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96
Citations
32383
World Ranking
9709
National Ranking
377

Overview

Jan W. Drijfhout is affiliated with Leiden University Medical Center in the Netherlands. Their research spans several interconnected fields, primarily focusing on Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

The scientist's work emphasizes subfields such as Molecular Biology, Microbiology, Immunology, Radiology, Nuclear Medicine and Imaging, and Oncology. Within these realms, Drijfhout explores topics including Antimicrobial Peptides and Activities, Biochemical and Structural Characterization, Monoclonal and Polyclonal Antibodies Research, Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, Peptidase Inhibition and Analysis, as well as Rheumatoid Arthritis Research and Therapies.

Several recent papers illustrate the breadth of Drijfhout's research contributions:

  • Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications, 2020, Annals of the Rheumatic Diseases
  • A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection, 2022, Nature Communications
  • CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides, 2023, Antibiotics
  • Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media, 2020, PLoS ONE

Drijfhout has collaborated frequently with several researchers, including Robert A. Cordfunke, Peter H. Nibbering, Peter A. van Veelen, Natasja Dolezal, and Miriam E. van Gent.

The scientist's publications have appeared often in venues such as Antibiotics, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Biomolecules, and Analytical Chemistry. These journals reflect a focus on antimicrobial research, biochemical characterization, and molecular biology.

Best Publications

  • Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

    M. C. W. Feltkamp;H. L. Smits;M. P. M. Vierboom;R. P. Minnaar

  • The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

    Willemijn Vader;Yvonne Kooy;Peter van Veelen;Arnoud de Ru

  • The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor

    G. Sandra Tjabringa;Jamil Aarbiou;Dennis K. Ninaber;Jan Wouter Drijfhout

  • Cross-presentation by intercellular peptide transfer through gap junctions

    Joost Neijssen;Carla Herberts;Jan Wouter Drijfhout;Eric Reits

  • Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.

    W. A. Erik Marijt;Mirjam H. M. Heemskerk;Freke M. Kloosterboer;Els Goulmy

  • Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease

    L. Willemijn Vader;Arnoud de Ru;Yvonne van der Wal;Yvonne M.C. Kooy

  • Identification of a Graft-versus-Host Disease-associated human minor Histocompatibility antigen.

    Joke M. M. den Haan;Nicholas E. Sherman;Els Blokland;Eric Huczko

  • The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

    Anna de Breij;Martijn Riool;Robert A. Cordfunke;Nermina Malanovic

  • High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

    Sytse J. Piersma;Ekaterina S. Jordanova;Mariëtte I.E. van Poelgeest;Kitty M.C. Kwappenberg

  • Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.

    Marij J P Welters;Gemma G Kenter;Sytse J Piersma;Annelies P G Vloon

  • MANNOSE RECEPTOR-MEDIATED UPTAKE OF ANTIGENS STRONGLY ENHANCES HLA CLASS II-RESTRICTED ANTIGEN PRESENTATION BY CULTURED DENDRITIC CELLS

    M. C. A. A. Tan;A. M. Mommaas;J. W. Drijfhout;R. Jordens

  • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

    Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif

  • The HLA-A^*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition

    Leslie Meadows;Wei Wang;Joke M.M den Haan;Els Blokland

  • Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity

    Gemma G Kenter;Marij J P Welters;A Rob P M Valentijn;Margriet J G Lowik

  • Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

    Diane van der Woude;Solbritt Rantapää-Dahlqvist;Andreea Ioan-Facsinay;Carla Onnekink

  • Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

    Eric Reits;Alexander Griekspoor;Joost Neijssen;Tom Groothuis

  • Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6

    Annemieke de Jong;Mariëtte I. E. van Poelgeest;Jeanette M. van der Hulst;Jan Wouter Drijfhout

  • Efficient Identification of Novel HLA-A * 0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis

    Jan H. Kessler;Nico J. Beekman;Sandra A. Bres-Vloemans;Pauline Verdijk

  • A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

    Eric Reits;Joost Neijssen;Carla Herberts;Willemien Benckhuijsen

Frequent Co-Authors

Frits Koning
Frits Koning Leiden University Medical Center
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Sjoerd H. van der Burg
Sjoerd H. van der Burg Leiden University Medical Center
Bart O. Roep
Bart O. Roep Leiden University Medical Center
Rienk Offringa
Rienk Offringa German Cancer Research Center
Kees L. M. C. Franken
Kees L. M. C. Franken Leiden University Medical Center
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Peter H. Nibbering
Peter H. Nibbering Leiden University Medical Center
Gemma G. Kenter
Gemma G. Kenter Vrije Universiteit Amsterdam

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