World's Best Scientists 2026 revealed!
Award Badge
Immunology
Netherlands
2026
Award Badge
Medicine
Netherlands
2023

D-Index & Metrics

Immunology

D-Index
124
Citations
59635
World Ranking
297
National Ranking
10

Medicine

D-Index
124
Citations
59635
World Ranking
3212
National Ranking
118

Research.com Recognitions

  • 2026 - Research.com Immunology in Netherlands Leader Award
  • 2025 - Research.com Immunology in Netherlands Leader Award
  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2022 - Research.com Immunology in Netherlands Leader Award

Overview

René E. M. Toes is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a notable focus on several specialized subfields.

The main areas of study for René E. M. Toes include:

  • Medicine
  • Immunology and Microbiology

The scientist's work covers important subfields such as:

  • Rheumatology
  • Immunology
  • Radiology, Nuclear Medicine and Imaging
  • Pathology and Forensic Medicine
  • Molecular Biology

The primary research topics addressed by René E. M. Toes involve:

  • Monoclonal and Polyclonal Antibodies Research
  • Systemic Lupus Erythematosus Research
  • Rheumatoid Arthritis Research and Therapies
  • T-cell and B-cell Immunology
  • Systemic Sclerosis and Related Diseases
  • Glycosylation and Glycoproteins Research
  • Autoimmune Bullous Skin Diseases

René E. M. Toes has contributed extensively to scientific literature, publishing in several respected venues. The most frequent publication venues include:

  • Annals of the Rheumatic Diseases
  • RMD Open
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arthritis Research & Therapy
  • Arthritis & Rheumatology

Several recent papers authored or co-authored by René E. M. Toes highlight ongoing contributions to immunology and autoimmune disease research:

  • Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses (2020, Cells)
  • Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial (2024, The Lancet)
  • Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications (2020, Annals of the Rheumatic Diseases)
  • Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis (2020, Science Translational Medicine)
  • Onset of rheumatoid arthritis after COVID-19: coincidence or connected? (2021, Annals of the Rheumatic Diseases)

The scientist frequently collaborates with other researchers, including:

  • T. Huizinga
  • Hans Ulrich Scherer
  • Diane van der Woude
  • Theresa Kissel
  • Tineke J van Wesemael

Best Publications

  • T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

    S. P. Schoenberger;R. E. M. Toes;E. I. H. Van Der Voort;R. Offringa

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.

    R. P.M. Sutmuller;L. M. Van Duivenvoorde;A. Van Elsas;T. N.M. Schumacher

  • Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells.

    Jun Wang;Andreea Ioan-Facsinay;Ellen I. H. van der Voort;Tom W. J. Huizinga

  • Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study.

    F.A. van Gaalen;S.P. Linn-Rasker;W.J.W. van Venrooij;B.A. de Jong

  • Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

    Ulrike Harre;Dan Georgess;Holger Bang;Aline Bozec

  • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

    Steve Eyre;John Bowes;John Bowes;Dorothée Diogo;Dorothée Diogo;Annette Lee

  • Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.

    Tom W. J. Huizinga;Christopher I. Amos;Annette H. M. van der Helm-van Mil;Wei Chen

  • Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

    B.J.E. de Lange-Brokaar;A. Ioan-Facsinay;G.J.V.M. van Osch;A.-M. Zuurmond

  • Decreased tumor surveillance in perforin-deficient mice.

    M. F. Van Den Broek;D. Kagi;F. Ossendorp;R. Toes

  • Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

    Jing Shi;Rachel Knevel;Parawee Suwannalai;Michael P. van der Linden

  • Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis

    Annette H M van der Helm-van Mil;Kirsten N Verpoort;Ferdinand C Breedveld;René E M Toes

  • CD4 T cells and their role in antitumor immune responses.

    René E.M. Toes;Ferry Ossendorp;Rienk Offringa;Cornelis J.M. Melief

  • Common variants at CD40 and other loci confer risk of rheumatoid arthritis

    Soumya Raychaudhuri;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Annette T Lee;Rachel Hackett

  • Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.

    Mary E. Morgan;Jolanda H.M. van Bilsen;Aleida M. Bakker;Bianca Heemskerk

  • Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis

    Henrik Källberg;Leonid Padyukov;Robert M. Plenge;Robert M. Plenge;Johan Rönnelid

  • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy.

    Diehl L;den Boer At;Schoenberger Sp;van der Voort Ei

  • The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor.

    Harpreet Singh-Jasuja;Hans Ulrich Scherer;Norbert Hilf;Danièle Arnold-Schild

  • Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled trial

    Henrike van Dongen;Jill van Aken;Leroy R Lard;Karen Visser

  • Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid Arthritis

    Floris A van Gaalen;Jill van Aken;Tom W J Huizinga;Geziena M Th Schreuder

Frequent Co-Authors

Tom W. J. Huizinga
Tom W. J. Huizinga Leiden University Medical Center
Leendert A. Trouw
Leendert A. Trouw Leiden University Medical Center
Rienk Offringa
Rienk Offringa German Cancer Research Center
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Lars Klareskog
Lars Klareskog Karolinska Institute
Alexandra Zhernakova
Alexandra Zhernakova University Medical Center Groningen
Peter K. Gregersen
Peter K. Gregersen Feinstein Institute for Medical Research
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Robert M. Plenge
Robert M. Plenge Bristol Myers Squibb

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those studying Immunology in the USA, exploring related healthcare degrees can broaden career opportunities. Many students consider nursing pathways because the clinical understanding gained from Immunology aligns well with patient care roles. For instance, earning an acute care nurse practitioner certification can open doors to specialized roles in critical and acute care settings.

If you are already a registered nurse looking to advance, accelerated RN to NP programs offer a faster route to becoming a nurse practitioner. These programs are designed to build on prior nursing education efficiently, making them ideal for those aiming to leverage their clinical experience quickly.

For individuals without a nursing background, the best online RN programs for non nurses provide accessible entry points into the nursing profession. These programs often feature flexible schedules and comprehensive curriculum, allowing students to transition smoothly into healthcare roles.

Furthermore, for those seeking less competitive enrollment options, the easiest accelerated nursing programs to get into can be an attractive option, balancing accessibility with quality education. Exploring these pathways can complement an Immunology degree with practical nursing skills and certifications, enhancing career prospects in health and research sectors.

Best Scientists Citing René E. M. Toes

Trending Scientists