2026 Leendert A. Trouw: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	70	2443	2244	96	92	293	14996

Overview

Leendert A. Trouw is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of medicine and immunology and microbiology, with notable contributions to subfields such as immunology, rheumatology, radiology, nuclear medicine and imaging, infectious diseases, and hepatology.

The main topics of their scientific work include:

Monoclonal and Polyclonal Antibodies Research
Complement system in diseases
Systemic Lupus Erythematosus Research
Rheumatoid Arthritis Research and Therapies
Liver Diseases and Immunity
Glycosylation and Glycoproteins Research
Platelet Disorders and Treatments

Leendert A. Trouw has published extensively in well-known journals. Frequent publication venues include:

Annals of the Rheumatic Diseases
Immunobiology
Arthritis Research & Therapy
RMD Open
Proceedings of the National Academy of Sciences

The scientist has collaborated repeatedly with various colleagues. Frequent co-authors are:

Douwe J. Dijkstra
René E. M. Toes
Thomas H. Sharp
Kyra A. Gelderman
T. Huizinga

Recent significant publications by Leendert A. Trouw include:

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19, 2021, Nature Immunology
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains, 2023, Nature Communications
Circulating C1q levels in health and disease, more than just a biomarker, 2021, Molecular Immunology
PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation, 2022, Proceedings of the National Academy of Sciences
The role of complement activation in autoimmune liver disease, 2020, Autoimmunity Reviews

Best Publications

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

Jing Shi;Rachel Knevel;Parawee Suwannalai;Michael P. van der Linden

696
Citations
Production of complement components by cells of the immune system

R Lubbers;M F van Essen;C van Kooten;L A Trouw

475
Citations
Complement activation and inhibition: a delicate balance.

A. P. Sjoberg;L. A. Trouw;Anna Blom

468
Citations
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation.

Alma J. Nauta;Leendert A. Trouw;Mohamed R. Daha;Odette Tijsma

416
Citations
Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.

Helen Benham;Helen Benham;Hendrik J. Nel;Soi Cheng Law;Ahmed M. Mehdi

402
Citations
Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

Yoann Rombouts;Ewoud Ewing;Lotte A van de Stadt;Maurice H J Selman

324
Citations
Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

L. A. Trouw;E. M. Haisma;E. W. N. Levarht;D. van der Woude

305
Citations
Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes

Leendert A. Trouw;Tom W.L. Groeneveld;Marc A. Seelen;Jacques M.G.J. Duijs

304
Citations
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

Mariana Gaya de Costa;Felix Poppelaars;Felix Poppelaars;Cees van Kooten;Tom Eirik Mollnes;Tom Eirik Mollnes;Tom Eirik Mollnes

288
Citations
The influence of ACPA status and characteristics on the course of RA

Annemiek Willemze;Leendert A. Trouw;René E. M. Toes;Tom W. J. Huizinga

273
Citations
Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

Jing Shi;Lotte A van de Stadt;E W Nivine Levarht;Tom W J Huizinga

263
Citations
Glycan profiling of anti–citrullinated protein antibodies isolated from human serum and synovial fluid

Hans U. Scherer;Diane van der Woude;Andreea Ioan-Facsinay;Hanane el Bannoudi

256
Citations
Anti-Carbamylated Protein Antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis

Jing Shi;Lotte A. van de Stadt;E. W. Nivine Levarht;Tom W. J. Huizinga

251
Citations
The complement system as a potential therapeutic target in rheumatic disease

Leendert A. Trouw;Matthew C. Pickering;Anna M. Blom

241
Citations
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

Yoann Rombouts;Annemiek Willemze;Joyce J B C van Beers;Jing Shi

237
Citations
Role of complement and complement regulators in the removal of apoptotic cells.

L. A. Trouw;A. M. Blom;Philippe Gasque

233
Citations
Complement activation by (auto-) antibodies.

Nina A. Daha;Nirmal K. Banda;Anja Roos;Frank J. Beurskens

212
Citations
Maturation of dendritic cells abrogates C1q production in vivo and in vitro.

Giuseppe Castellano;Andrea M. Woltman;Andrea M. Woltman;Alma J. Nauta;Alma J. Nauta;Anja Roos;Anja Roos

205
Citations
The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells

Andreas P. Sjöberg;Leendert A. Trouw;Simon J. Clark;Jonatan Sjölander

200
Citations
Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation

Wei Xu;Stefan Berger;Leendert Trouw;Hetty de Boer

193
Citations

Frequent Co-Authors

René E. M. Toes Leiden University Medical Center

Tom W. J. Huizinga Leiden University Medical Center

Anna M. Blom Lund University

Mohamed R. Daha Leiden University

Cees van Kooten Leiden University Medical Center

Anja Roos Leiden University Medical Center

Jan W. Drijfhout Leiden University Medical Center

Peter A. van Veelen Leiden University Medical Center

Solbritt Rantapää-Dahlqvist Umeå University

Jeanine J. Houwing-Duistermaat University of Leeds

External Links

Personal website of Leendert A. Trouw

If you think any of the details on this page are incorrect, let us know.

Related Online Degrees & Career Pathways

For those interested in Immunology, exploring related nursing and healthcare degrees can open up diverse career opportunities. Many professionals choose to enhance their credentials through specialized paths like Nurse Practitioner certifications. For example, pursuing the acute care nurse practitioner certification allows nurses to work in high-demand settings such as intensive care units and emergency departments.

Accelerated programs are popular among those with a background in science or healthcare who wish to quickly transition into advanced nursing roles. An accelerated FNP program offers a streamlined route to becoming a Family Nurse Practitioner, balancing speed and comprehensive training.

For individuals without a nursing background, there are excellent options for starting fresh. High-quality online nursing programs for non nurses provide accessible pathways to enter the nursing profession, combining flexibility with rigorous coursework.

Compensation is also a key consideration. Understanding the DNP salary variation by location can help professionals make informed decisions about where to study and work, maximizing their career potential in the healthcare field.