World's Best Scientists 2026 revealed!

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Immunology

D-Index
80
Citations
20445
World Ranking
1647
National Ranking
66

Medicine

D-Index
80
Citations
20475
World Ranking
17249
National Ranking
651

Overview

Cees van Kooten is affiliated with Leiden University Medical Center in the Netherlands. Their research mainly focuses on immunology, nephrology, and related medical fields, with a significant contribution to understanding renal diseases and immune system mechanisms.

The scientist's publication record spans multiple subjects, especially within Medicine and Immunology and Microbiology. Their primary subfields of study include Immunology, Nephrology, Rheumatology, Transplantation, and Hematology.

The main topics addressed in their work are:

  • Renal Diseases and Glomerulopathies
  • Renal Transplantation Outcomes and Treatments
  • Systemic Lupus Erythematosus Research
  • Complement system in diseases
  • T-cell and B-cell Immunology
  • Platelet Disorders and Treatments
  • Chronic Kidney Disease and Diabetes

Frequent publication venues where Cees van Kooten's work appears include:

  • Nephrology Dialysis Transplantation
  • Frontiers in Immunology
  • Kidney International
  • American Journal of Transplantation
  • Immunobiology

They have collaborated repeatedly with a number of co-authors, including:

  • Ton J. Rabelink (28 publications)
  • Y K Onno Teng (18 publications)
  • Eline J. Arends (15 publications)
  • Marlies E. J. Reinders (13 publications)
  • Sylvia W.A. Kamerling (12 publications)

Examples of their recent scholarly papers include:

  • Development and testing of an artificial intelligence tool for predicting end-stage kidney disease in patients with immunoglobulin A nephropathy, 2020, Kidney International
  • The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference, 2024, Kidney International
  • Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results, 2020, Nephrology Dialysis Transplantation
  • Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys, 2021, Frontiers in Immunology
  • Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy, 2022, Kidney International

The breadth of Cees van Kooten's research covers disease mechanisms, prediction tools, and treatment outcomes, with particular attention to immune-mediated kidney diseases and systemic autoimmune conditions.

Best Publications

  • Functions of CD40 on B cells, dendritic cells and other cells

    Cees van Kooten;Jacques Banchereau

  • Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease.

    Anja Roos;Maria Pia Rastaldi;Novella Calvaresi;Beatrijs D. Oortwijn

  • CD40-CD40 LIGAND : A MULTIFUNCTIONAL RECEPTOR-LIGAND PAIR

    C. Van Kooten;J. Banchereau

  • Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes

    Bertrand Dubois;Béatrice Vanbervliet;Jérome Fayette;Catherine Massacrier

  • Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study

    Marlies E.J. Reinders;Johan W. de Fijter;Helene Roelofs;Ingeborg M. Bajema

  • TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)

    Frank Strutz;Michael Zeisberg;Anja Renziehausen;Birgit Raschke

  • A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation.

    D Graf;S Müller;U Korthäuer;C van Kooten

  • The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells.

    Andrea M. Woltman;Johan W. de Fijter;Sylvia W.A. Kamerling;Leendert C. Paul

  • Opsonization with C1q and Mannose-Binding Lectin Targets Apoptotic Cells to Dendritic Cells

    Alma J. Nauta;Giuseppe Castellano;Wei Xu;Andrea M. Woltman

  • Recognition and clearance of apoptotic cells: a role for complement and pentraxins.

    Alma J Nauta;Mohamed R Daha;Cees van Kooten;Anja Roos

  • Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes

    Leendert A. Trouw;Tom W.L. Groeneveld;Marc A. Seelen;Jacques M.G.J. Duijs

  • Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.

    Michael C Graves;Milan Fiala;Lu Anne V Dinglasan;Nancy Q Liu

  • Chronic renal allograft rejection: pathophysiologic considerations.

    Simone A. Joosten;Yvo W.J. Sijpkens;Cornelis Van Kooten;Leendert C. Paul

  • Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

    Mariana Gaya de Costa;Felix Poppelaars;Felix Poppelaars;Cees van Kooten;Tom Eirik Mollnes;Tom Eirik Mollnes;Tom Eirik Mollnes

  • IL-10–producing macrophages preferentially clear early apoptotic cells

    Wei Xu;Anja Roos;Nicole Schlagwein;Andrea M. Woltman

  • Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

    Marina D. Kraaij;Nigel D. L. Savage;Sandra W. van der Kooij;Karin Koekkoek

  • Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.

    Carelle C. Reparon-Schuijt;Wim J. E. van Esch;Cees van Kooten;Gerard A. Schellekens

  • Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10

    Delphine Rea;Cees van Kooten;Krista E. van Meijgaarden;Tom H. M. Ottenhoff

  • B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40.

    C van Kooten;C Gaillard;J P Galizzi;P Hermann

  • CD40 Ligation on Human Cord Blood CD34+Hematopoietic Progenitors Induces Their Proliferation and Differentiation into Functional Dendritic Cells

    Leopoldo Flores-Romo;Pia Björck;Valérie Duvert;Cees van Kooten

  • A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

    Sucharitha Balu;Rajko Reljic;Melanie J. Lewis;Richard J. Pleass;Richard J. Pleass

  • Maturation of dendritic cells abrogates C1q production in vivo and in vitro.

    Giuseppe Castellano;Andrea M. Woltman;Andrea M. Woltman;Alma J. Nauta;Alma J. Nauta;Anja Roos;Anja Roos

Frequent Co-Authors

Mohamed R. Daha
Mohamed R. Daha Leiden University
Ton J. Rabelink
Ton J. Rabelink Leiden University Medical Center
Anja Roos
Anja Roos Leiden University Medical Center
Frans H.J. Claas
Frans H.J. Claas Leiden University Medical Center
Dave L. Roelen
Dave L. Roelen Leiden University Medical Center
Leendert A. Trouw
Leendert A. Trouw Leiden University Medical Center
Ilias I.N. Doxiadis
Ilias I.N. Doxiadis Leiden University Medical Center
Simone A. Joosten
Simone A. Joosten Leiden University Medical Center
Arend Mulder
Arend Mulder Leiden University Medical Center

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