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Immunology

D-Index
52
Citations
8685
World Ranking
4080
National Ranking
161

Overview

Simone A. Joosten is affiliated with Leiden University Medical Center in the Netherlands. Their research focuses primarily on immunology, infectious diseases, and epidemiology with a significant concentration on tuberculosis and immune cell function.

The scientist has contributed extensively to the study of tuberculosis, immune responses, and infection-related immunology. Their main fields of study include Medicine and Immunology and Microbiology, with subfields covering Immunology, Infectious Diseases, Epidemiology, Molecular Biology, and Neurology. Key topics they have explored are:

  • Tuberculosis Research and Epidemiology
  • Immune Cell Function and Interaction
  • Mycobacterium Research and Diagnosis
  • T-cell and B-cell Immunology
  • Immune Responses and Vaccinations
  • COVID-19 Clinical Research Studies
  • Immunotherapy and Immune Responses

Simone A. Joosten's recent publications highlight the diverse scope and impact of their work. Notable papers include:

  • "RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response" (2020, Scientific Reports)
  • "Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19" (2021, Nature Immunology)
  • "B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis" (2021, Frontiers in Immunology)
  • "T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection" (2023, Nature Medicine)
  • "Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis" (2020, Clinical Infectious Diseases)

The scientist frequently publishes in a variety of venues, reflecting interdisciplinary work across immunology and infectious diseases. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Scientific Reports
  • iScience
  • The Journal of Immunology

Throughout their career, Simone A. Joosten has collaborated regularly with several researchers, evidencing extensive co-authorship networks. Frequent collaborators are:

  • Tom H. M. Ottenhoff
  • Krista E. van Meijgaarden
  • Kees L. M. C. Franken
  • Thomas J. Scriba
  • Delia Goletti

Best Publications

  • Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection

    Nadia Caccamo;Giuliana Guggino;Simone A. Joosten;Giuseppe Gelsomino

  • Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

    Nigel D. L. Savage;Tjitske de Boer;Kimberley V. Walburg;Simone A. Joosten

  • Chronic renal allograft rejection: pathophysiologic considerations.

    Simone A. Joosten;Yvo W.J. Sijpkens;Cornelis Van Kooten;Leendert C. Paul

  • Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

    Sara Suliman;Ethan G. Thompson;Jayne Sutherland;January Weiner rd

  • A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human.

    Jaap T. van Dissel;Simone A. Joosten;Søren T. Hoff;Darius Soonawala

  • Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

    Simone A. Joosten;Krista E. van Meijgaarden;Nigel D. L. Savage;Tjitske de Boer

  • Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.

    Elisa Petruccioli;Thomas J. Scriba;Linda Petrone;Mark Hatherill;Mark Hatherill

  • Mycobacterial growth inhibition is associated with trained innate immunity

    Simone A. Joosten;Krista E. van Meijgaarden;Sandra M. Arend;Corine Prins

  • Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination.

    Mardi C. Boer;Simone A. Joosten;Tom H. M. Ottenhoff

  • Tuberculosis Biomarkers: From Diagnosis to Protection

    Delia Goletti;Elisa Petruccioli;Simone A. Joosten;Tom H.M. Ottenhoff

  • Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination

    Simone A. Joosten;Tom H.M. Ottenhoff

  • Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8+ T-cells with cytotoxic as well as regulatory activity.

    Simone A. Joosten;Krista E. van Meijgaarden;Pascale C. van Weeren;Fatima Kazi

  • Antibody glycosylation in inflammation, disease and vaccination.

    Galit Alter;Tom H.M. Ottenhoff;Simone A. Joosten

  • Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.

    Jaap T. van Dissel;Darius Soonawala;Simone A. Joosten;Corine Prins

  • Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathy

    Yvo. W. Sijpkens;Yvo. W. Sijpkens;Simone A. Joosten;Simone A. Joosten;Man-Chi Wong;Man-Chi Wong;Friedo W. Dekker;Friedo W. Dekker

  • Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

    Simone A. Joosten;Krista E. van Meijgaarden;Franca del Nonno;Andrea Baiocchini

  • Real-time quantitative PCR for detection of minimal residual disease before allogeneic stem cell transplantation predicts outcome in children with acute lymphoblastic leukemia.

    V.H. van der Velden;S.A. Joosten;M.P. Willemse;E.R. van Wering

  • RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

    Adam Penn-Nicholson;Stanley Kimbung Mbandi;Ethan Thompson;Simon C Mendelsohn

  • Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy.

    Simone A. Joosten;Yvo W.J. Sijpkens;Vanessa Van Ham;Leendert A. Trouw

  • Metabolite changes in blood predict the onset of tuberculosis

    January rd Weiner;Jeroen Maertzdorf;Jayne S. Sutherland;Fergal J. Duffy

  • Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

    Simone A Joosten;Krista E van Meijgaarden;Pascale C van Weeren;Fatima Kazi

Frequent Co-Authors

Tom H. M. Ottenhoff
Tom H. M. Ottenhoff Leiden University Medical Center
Krista E. van Meijgaarden
Krista E. van Meijgaarden Leiden University Medical Center
Delia Goletti
Delia Goletti Istituto Sperimentale Italiano Lazzaro Spallanzani
Annemieke Geluk
Annemieke Geluk Leiden University Medical Center
Cees van Kooten
Cees van Kooten Leiden University Medical Center
Francesco Dieli
Francesco Dieli University of Palermo
Leendert A. Trouw
Leendert A. Trouw Leiden University Medical Center
Martin O. C. Ota
Martin O. C. Ota London School of Hygiene & Tropical Medicine
Jaap T. van Dissel
Jaap T. van Dissel Leiden University Medical Center
Richard A. Adegbola
Richard A. Adegbola Nigerian Institute of Medical Research

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