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Jürgen Hescheler

Jürgen Hescheler

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
32532
World Ranking
2099
National Ranking
147

Overview

Jürgen Hescheler is affiliated with the University of Cologne in Germany, focusing on biomedical research within the fields of biochemistry, genetics, molecular biology, and medicine.

They have contributed extensively to research areas including pluripotent stem cells, tissue engineering and regenerative medicine, CRISPR and genetic engineering, neuroscience and neuropharmacology, retinal development and disorders, and ion channel regulation and function.

Notable recent publications by Hescheler include:

  • "Human brain organoids assemble functionally integrated bilateral optic vesicles" (2021, Cell Stem Cell)
  • "Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives" (2021, Neural Plasticity)
  • "Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes" (2022, iScience)
  • "Co-transplantation of Mesenchymal Stromal Cells and Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improves Cardiac Function After Myocardial Damage" (2022, Frontiers in Cardiovascular Medicine)
  • "mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs" (2023, Science Advances)

Frequent coauthors in their publications include:

  • Agapios Sachinidis
  • Kurt Pfannkuche
  • Filomain Nguemo
  • Toni Schneider
  • Christina Henseler

Jürgen Hescheler's research is often published in journals such as:

  • Cells
  • Biomedicine & Pharmacotherapy
  • Cellular Physiology and Biochemistry
  • Scientific Reports
  • International Journal of Molecular Sciences

Their scientific contributions cover several subfields including molecular biology, cellular and molecular neuroscience, physiology, surgery, and cardiology and cardiovascular medicine. This interdisciplinary focus supports advances in stem cell research, cardiac repair technologies, and molecular mechanisms underlying cellular function and neural development.

Best Publications

  • Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.

    Jens Martin Nygren;Stefan Jovinge;Martin Breitbach;Petter Säwén

  • The GTP-binding protein, Go, regulates neuronal calcium channels.

    J. Hescheler;W. Rosenthal;W. Trautwein;G. Schultz

  • Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

    C. Kleuss;J. Hescheler;C. Ewel;W. Rosenthal

  • Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers

    Anna M. Wobus;Gerd Wallukat;Jürgen Hescheler

  • Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.

    J Hescheler;R Meyer;S Plant;D Krautwurst

  • Retinoic Acid Accelerates Embryonic Stem Cell-Derived Cardiac Differentiation and Enhances Development of Ventricular Cardiomyocytes ☆

    Anna M. Wobus;Guan Kaomei;Jin Shan;Marie-Cecile Wellner

  • Muscle Cell Differentiation of Embryonic Stem Cells Reflects Myogenesis in Vivo: Developmentally Regulated Expression of Myogenic Determination Genes and Functional Expression of Ionic Currents

    J. Rohwedel;V. Maltsev;E. Bober;H.-H. Arnold

  • Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons

    Carsten Strübing;Gudrun Ahnert-Hilger;Jin Shan;Bertram Wiedenmann

  • Different β-subunits determine G-protein interaction with transmembrane receptors

    C. Kleuss;H. Scherübl;J. Hescheler;G. Schultz

  • Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke.

    Franciska Erdö;Christian Bührle;James Blunk;Mathias Hoehn

  • Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current.

    W. Osterrieder;G. Brum;J. Hescheler;W. Trautwein

  • Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals

    Qiangzhe Zhang;Junjie Jiang;Pengcheng Han;Qi Yuan

  • Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

    Eugen Kolossov;Toktam Bostani;Wilhelm Roell;Martin Breitbach

  • Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species

    Maria Wartenberg;Frederike C. Ling;Markus Müschen;Florian Klein

  • Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells.

    Heinrich Sauer;Gohar Rahimi;Jürgen Hescheler;Maria Wartenberg

  • Cardiac specific differentiation of mouse embryonic stem cells

    Agapios Sachinidis;Bernd K Fleischmann;Eugen Kolossov;Maria Wartenberg

  • Modulation of Ca current during the phosphorylation cycle in the guinea pig heart.

    M. Kameyama;J. Hescheler;F. Hofmann;W. Trautwein

  • Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction

    Jochen Müller-Ehmsen;Benjamin Krausgrill;Volker Burst;Kerstin Schenk

  • Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells.

    Heinrich Sauer;Gohar Rahimi;Jürgen Hescheler;Maria Wartenberg

  • Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures.

    Marcel D. Halbach;Ulrich Egert;Jürgen Hescheler;Kathrin Banach

Frequent Co-Authors

Agapios Sachinidis
Agapios Sachinidis University of Cologne
Toni Schneider
Toni Schneider University of Cologne
Tomo Saric
Tomo Saric University of Cologne
Maria Wartenberg
Maria Wartenberg Friedrich Schiller University Jena
Heinrich Sauer
Heinrich Sauer University of Giessen
Bernd K. Fleischmann
Bernd K. Fleischmann University of Bonn
Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Günter Schultz
Günter Schultz Freie Universität Berlin
Klaus Addicks
Klaus Addicks University of Cologne
Herbert Schulz
Herbert Schulz University of Cologne

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