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Agapios Sachinidis

Agapios Sachinidis

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
13468
World Ranking
9259
National Ranking
678

Overview

Agapios Sachinidis is a researcher affiliated with the University of Cologne in Germany, specializing in fields related to biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields, including molecular biology, cardiology and cardiovascular medicine, physiology, cancer research, and oncology.

They have contributed significantly to research on pluripotent stem cells, demonstrating a particular focus on pluripotent stem cells research, CRISPR and genetic engineering, as well as chemotherapy-induced cardiotoxicity and its mitigation. Other areas explored in their research include 3D printing in biomedical research, tissue engineering and regenerative medicine, neuroscience and neural engineering, and molecular biology techniques and applications.

Sachinidis has been published in multiple scientific venues, with frequent contributions to:

  • Cells
  • Archives of Toxicology
  • Stem Cell Research & Therapy
  • Cell Death Discovery
  • PubMed

Selected recent publications include:

  • "IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors" (2021, Molecular Therapy)
  • "Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease" (2020, Archives of Toxicology)
  • "Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation" (2020, Nucleic Acids Research)
  • "Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs" (2020, Cells)
  • "Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes" (2022, iScience)

Their frequent co-authors include:

  • Jürgen Hescheler
  • Jan G. Hengstler
  • Harshal Nemade
  • Jörg Rahnenführer
  • Luying Peng

Best Publications

  • Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

    Michael Xavier Doss;Agapios Sachinidis

  • Upregulation of Vascular Angiotensin II Receptor Gene Expression by Low-Density Lipoprotein in Vascular Smooth Muscle Cells

    G. Nickenig;A. Sachinidis;F. Michaelsen;M. Bo¨hm

  • Cardiac specific differentiation of mouse embryonic stem cells

    Agapios Sachinidis;Bernd K Fleischmann;Eugen Kolossov;Maria Wartenberg

  • A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity

    Li Ding;Maciej Paszkowski-Rogacz;Anja Nitzsche;Mikolaj Michal Slabicki

  • A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction.

    S. Fronhoffs;G. Totzke;S. Stier;N. Wernert

  • Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation of sis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

    Hee-Yul Ahn;Kourosch Reza Hadizadeh;Claudia Seul;Yeo-Pyo Yun

  • Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

    Anne K. Krug;Raivo Kolde;John A. Gaspar;Eugen Rempel

  • Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases.

    Smita Jagtap;Kesavan Meganathan;Vilas Wagh;Johannes Winkler

  • Embryonic stem cells: a promising tool for cell replacement therapy

    Michael Xavier Doss;Christoph I. Koehler;C. Gissel;Jürgen Hescheler

  • Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells.

    A Sachinidis;R Locher;W Vetter;D Tatje

  • Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

    Patricio Godoy;Patricio Godoy;Wolfgang Schmidt-Heck;Karthick Natarajan;Baltasar Lucendo-Villarin

  • Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

    Lutz H. Block;Lyman R. Emmons;Esther Vogt;Agapios Sachinidis

  • Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr

    Michael Xavier Doss;José M. Di Diego;Robert J. Goodrow;Yuesheng Wu

  • Thromboxane A2 and Vascular Smooth Muscle Cell Proliferation

    Agapios Sachinidis;Markus Flesch;Yon Ko;Karsten Schrör

  • Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.

    Yon Ko;Josef Abel;Volker Harth;Peter Bröde

  • Toxicogenomics directory of chemically exposed human hepatocytes.

    Marianna Grinberg;Regina M. Stöber;Karolina Edlund;Eugen Rempel

  • Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

    Irène Aksoy;Vincent Giudice;Edwige Delahaye;Florence Wianny

  • Green tea compounds inhibit tyrosine phosphorylation of PDGF β‐receptor and transformation of A172 human glioblastoma

    Agapios Sachinidis;Claudia Seul;Stefan Seewald;Hee-Yul Ahn

  • Induced Pluripotent Stem Cells as a Model for Accelerated Patient- and Disease-specific Drug Discovery

    I. Gunaseeli;M. X. Doss;C. Antzelevitch;J. Hescheler

  • Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(

    Anne K. Krug;Simon Gutbier;Liang Zhao;Dominik Pöltl

Frequent Co-Authors

Jürgen Hescheler
Jürgen Hescheler University of Cologne
Yon Ko
Yon Ko University of Bonn
Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Marcel Leist
Marcel Leist University of Konstanz
Herbert Schulz
Herbert Schulz University of Cologne
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Georg Nickenig
Georg Nickenig University of Bonn
Hector C. Keun
Hector C. Keun Imperial College London
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Albert Sickmann
Albert Sickmann Leibniz Institute for Neurobiology

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