World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15919
World Ranking
9115
National Ranking
700

Overview

Hector C. Keun is affiliated with Imperial College London in the United Kingdom. Their research spans key fields including Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on Molecular Biology, Health, Toxicology and Mutagenesis, Cancer Research, Pediatrics, Perinatology and Child Health, and Public Health, Environmental and Occupational Health.

The scientist's work covers a range of topics relevant to health and environmental sciences. Their main topics of study include Health, Environment, Cognitive Aging; Birth, Development, and Health; Metabolomics and Mass Spectrometry Studies; Cancer, Hypoxia, and Metabolism; Nutritional Studies and Diet; Epigenetics and DNA Methylation; and Diet and metabolism studies.

Their recent publications provide insight into their research focus and collaborations. Selected papers include:

  • Multi-omics signatures of the human early life exposome, 2022, Nature Communications
  • A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer, 2023, Clinical Cancer Research
  • The early-life exposome and epigenetic age acceleration in children, 2021, Environment International
  • Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma, 2022, Nature Communications
  • RNA-binding motif protein 39 (RBM39): An emerging cancer target, 2020, British Journal of Pharmacology

Frequent co-authors contributing to their work are Léa Maître, Regina Gražulevičienė, Alexandros Siskos, Martine Vrijheid, and Mariona Bustamante.

The scientist's publications have appeared repeatedly in several venues, including bioRxiv (Cold Spring Harbor Laboratory), Environment International, ISEE Conference Abstracts, British Journal of Cancer, and BMC Medicine.

Best Publications

  • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.

    Olaf Beckonert;Hector C Keun;Timothy M D Ebbels;Jacob Bundy

  • Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

    John C Lindon;Jeremy K Nicholson;Elaine Holmes;Henrik Antti

  • The Human Early-Life Exposome (HELIX): Project Rationale and Design

    Martine Vrijheid;Rémy Slama;Oliver Robinson;Leda Chatzi

  • High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

    Olaf Beckonert;Muireann Coen;Hector C Keun;Yulan Wang

  • Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

    Atanas Kamburov;Rachel Cavill;Timothy M. D. Ebbels;Ralf Herwig

  • The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

    John C Lindon;Hector C Keun;Timothy Md Ebbels;Jake Mt Pearce

  • Analytical reproducibility in (1)H NMR-based metabonomic urinalysis.

    Hector C Keun;Timothy M D Ebbels;Henrik Antti;Mary E Bollard

  • Summary recommendations for standardization and reporting of metabolic analyses.

    John C Lindon;Jeremy K Nicholson;Elaine Holmes;Hector C Keun

  • Impact of analytical bias in metabonomic studies of human blood serum and plasma.

    Orla Teahan;Simon Gamble;Elaine Holmes;Jonathan Waxman

  • Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies.

    Hector C. Keun;Olaf Beckonert;Julian L. Griffin;Christian Richter

  • Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma

    Alexandros P. Siskos;Pooja Jain;Werner Römisch-Margl;Mark Bennett

  • Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling

    Hector C. Keun;Timothy M.D. Ebbels;Henrik Antti;Mary E. Bollard

  • Metabolomics in Toxicology and Preclinical Research

    Tzutzuy Ramirez;Mardas Daneshian;Hennicke Kamp;Frederic Y. Bois

  • Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues.

    Yulan Wang;Mary E. Bollard;Hector Keun;Henrik Antti

  • Metabonomic modeling of drug toxicity.

    Hector C. Keun

  • Prediction and Classification of Drug Toxicity Using Probabilistic Modeling of Temporal Metabolic Data: The Consortium on Metabonomic Toxicology Screening Approach

    Timothy M D Ebbels;Hector C Keun;Olaf P Beckonert;Mary E Bollard

  • NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches

    Olaf Beckonert;Mary E. Bollard;Timothy M.D Ebbels;Hector C Keun

  • Citrate transport and metabolism in mammalian cells: prostate epithelial cells and prostate cancer.

    Maria E. Mycielska;Ameet Patel;Nahit Rizaner;Maciej P. Mazurek

  • Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles.

    Hector C Keun;Timothy M D Ebbels;Mary E Bollard;Olaf Beckonert

  • Comparative metabonomics of differential hydrazine toxicity in the rat and mouse

    Mary E. Bollard;Hector C. Keun;Olaf Beckonert;Tim M.D. Ebbels

Frequent Co-Authors

Jeremy K. Nicholson
Jeremy K. Nicholson Murdoch University
Elaine Holmes
Elaine Holmes Imperial College London
John C. Lindon
John C. Lindon Imperial College London
Jos C. S. Kleinjans
Jos C. S. Kleinjans Maastricht University
John Wright
John Wright National Health Service
Agapios Sachinidis
Agapios Sachinidis University of Cologne
Martine Vrijheid
Martine Vrijheid Pompeu Fabra University
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Juan R. González
Juan R. González Barcelona Institute for Global Health
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel

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