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Jos C. S. Kleinjans

Jos C. S. Kleinjans

D-Index & Metrics

Genetics

D-Index
65
Citations
16165
World Ranking
2696
National Ranking
103

Overview

Jos C. S. Kleinjans is affiliated with Maastricht University in the Netherlands. Their research spans the fields of medicine and biochemistry, genetics, and molecular biology, with a notable focus on molecular biology and oncology among other subfields.

The scientist's work covers several main topics, including:

  • Chemotherapy-induced cardiotoxicity and mitigation
  • Computational drug discovery methods
  • Metabolomics and mass spectrometry studies
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Pharmacogenetics and drug metabolism
  • Cancer cells and metastasis

Kleinjans has frequently published in several venues, including:

  • Archives of Toxicology
  • International Journal of Molecular Sciences
  • Toxicology Letters
  • Environmental Pollution
  • F1000Research

Recent research papers authored or co-authored by Jos C. S. Kleinjans include:

  • "Comparing in vitro human liver models to in vivo human liver using RNA-Seq" (2020), published in Archives of Toxicology
  • "Network integration and modelling of dynamic drug responses at multi-omics levels" (2020), published in Communications Biology
  • "New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids" (2021), published in Archives of Toxicology
  • "Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability" (2021), published in Scientific Reports
  • "Omics technologies to understand drug toxicity mechanisms" (2022), published in Drug Discovery Today

Frequent co-authors in Kleinjans' publications include:

  • Danyel Jennen
  • Florian Caiment
  • Theo M. de Kok
  • Yannick Schrooders
  • Marcel van Herwijnen

Best Publications

  • A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

    Zhenqiang Su;Paweł P. Łabaj;Sheng Li;Jean Thierry-Mieg

  • Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

    Sarah Adler;David Basketter;Stuart Creton;Olavi Pelkonen

  • The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

    Charles Wang;Binsheng Gong;Pierre R. Bushel;Jean Thierry-Mieg

  • Toward interoperable bioscience data

    Susanna-Assunta Sansone;Philippe Rocca-Serra;Dawn Field;Eamonn Maguire

  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

    Norihiro Kato;Marie Loh;Marie Loh;Marie Loh;Fumihiko Takeuchi;Niek Verweij

  • In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers

    Agnes W. Boots;Lonneke C. Wilms;Els L.R. Swennen;Jos C.S. Kleinjans

  • DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

    Marcha C.T. Verheijen;Matthias Lienhard;Yannick Schrooders;Olivia Clayton

  • The exposome in practice: Design of the EXPOsOMICS project.

    P. Vineis;M. Chadeau-Hyam;H. Gmuender;J. Gulliver

  • Transcriptomic and metabolomic data integration

    Rachel Cavill;Danyel Jennen;Jos Kleinjans;Jacob Jan Briedé

  • Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

    Danyel G. J. Jennen;Christina Magkoufopoulou;Hans B. Ketelslegers;Hans B. Ketelslegers;Marcel H. M. van Herwijnen

  • Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders.

    M.M.J. van den Berg;J. Krauskopf;J.G. Ramaekers;J.C.S. Kleinjans

  • Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes

    Lonneke C. Wilms;Peter C.H. Hollman;Agnes W. Boots;Jos C.S. Kleinjans

  • A dictionary to identify small molecules and drugs in free text

    Kristina M. Hettne;Rob H. Stierum;Martijn J. Schuemie;Peter J. M. Hendriksen

  • From the exposome to mechanistic understanding of chemical-induced adverse effects

    Beate I. Escher;Jörg Hackermüller;Tobias Polte;Stefan Scholz

  • Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue

    F.J. van Schooten;A. Hirvonen;L.M. Maas;B.A. de Mol

  • Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

    Heidrun Ellinger-Ziegelbauer;Jiri Aubrecht;Jos C. Kleinjans;Hans-Juergen Ahr

  • Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling

    J.H.M. van Delft;E. van Agen;S.G.J. van Breda;M.H. Herwijnen

  • Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research.

    Dennie G. A. J. Hebels;Panagiotis Georgiadis;Hector C. Keun;Toby J. Athersuch

  • Toxicogenomics directory of chemically exposed human hepatocytes.

    Marianna Grinberg;Regina M. Stöber;Karolina Edlund;Eugen Rempel

  • Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter.

    Theo M. de Kok;Janneke G. Hogervorst;Jacco J. Briedé;Marcel H. van Herwijnen

Frequent Co-Authors

Joost H.M. van Delft
Joost H.M. van Delft Maastricht University
Roger W. L. Godschalk
Roger W. L. Godschalk Maastricht University
Aldert H. Piersma
Aldert H. Piersma Centre for Health Protection
Greet Schoeters
Greet Schoeters University of Antwerp
Paolo Vineis
Paolo Vineis Imperial College London
Roel Vermeulen
Roel Vermeulen Utrecht University
Domenico Palli
Domenico Palli Institute for the Study and Prevention of Cancer (Istituto per lo Studio, la Prevenzione e la Rete Oncologica)
Micheline Kirsch-Volders
Micheline Kirsch-Volders Vrije Universiteit Brussel
Manolis Kogevinas
Manolis Kogevinas Pompeu Fabra University
Ralf Herwig
Ralf Herwig Max Planck Society

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