Jan G. Hengstler

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Germany Leader Award
• 2025 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Best Publications

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

  Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  1158
  Citations

• The humoral immune system has a key prognostic impact in node-negative breast cancer.

  Marcus Schmidt;Daniel Böhm;Christian von Törne;Eric Steiner

  1099
  Citations

• Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

  Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  993
  Citations

• Molecular Modes of Action of Artesunate in Tumor Cell Lines

  Thomas Efferth;Axel Sauerbrey;Armin Olbrich;Erich Gebhart

  588
  Citations

• Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer—what limits limited disease?

  Patrick Micke;Andreas Faldum;Tsegay Metz;Kai-Michael Beeh

  503
  Citations

• A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  Nathaniel Rothman;Montserrat Garcia-Closas;Nilanjan Chatterjee;Nuria Malats

  499
  Citations

• Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo

  H Aurich;M Sgodda;P Kaltwasser;M Vetter

  464
  Citations

• A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.

  Michael Arand;Roland Mühlbauer;Jan Hengstler;Elke Jäger

  448
  Citations

• Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers

  Ines Aurich;Lutz P Mueller;Hendryk Aurich;Jana Luetzkendorf

  412
  Citations

• Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

  Olivier Frey;Patrick M. Misun;David A. Fluri;Jan G. Hengstler

  403
  Citations

• Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

  Anja Zeigerer;Jerome Gilleron;Roman L. Bogorad;Giovanni Marsico

  389
  Citations

• Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration.

  Stefan Hoehme;Marc Brulport;Alexander Bauer;Essam Bedawy

  389
  Citations

• Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A

  J. G. Hengstler;H. Foth;T. Gebel;P.-J. Kramer

  386
  Citations

• Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

  W. Lilienblum;W. Dekant;H. Foth;T. Gebel

  383
  Citations

• Adverse outcome pathways: opportunities, limitations and open questions.

  Marcel Leist;Ahmed Ghallab;Ahmed Ghallab;Rabea Graepel;Rosemarie Marchan

  378
  Citations

• Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction.

  Jan G. Hengstler;D. Utesch;P. Steinberg;K. L. Platt

  341
  Citations

• Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected

  Jan G. Hengstler;Ulrich Bolm-Audorff;Andreas Faldum;Kai Janssen

  340
  Citations

• Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis and tissue microarray validation

  Johan Botling;Karolina Edlund;Miriam Lohr;Birte Hellwig

  326
  Citations

• New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.

  Rolf Gebhardt;Jan G Hengstler;Dieter Müller;Reinhild Glöckner

  316
  Citations

• Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.

  J. G. Hengstler;M. Arand;M. E. Herrero;F. Oesch

  306
  Citations