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Biology and Biochemistry

D-Index
77
Citations
17618
World Ranking
4871
National Ranking
362

Overview

Hansruedi Glatt is affiliated with the Federal Institute for Risk Assessment in Germany. The research work centers on biochemistry, genetics, and molecular biology, covering twenty publications in these areas. Their subfields of study include molecular biology, cancer research, health, toxicology and mutagenesis, pharmacology, and organic chemistry.

Their research topics encompass a focus on carcinogens and genotoxicity assessment, genomics involving phytochemicals and oxidative stress, glutathione transferases and polymorphisms, effects and risks of endocrine disrupting chemicals, free radicals and antioxidants, plant toxicity and pharmacological properties, and genetically modified organisms research.

Key recent papers authored or co-authored by Hansruedi Glatt include:

  • Influence of Bisphenol Compounds at Nanomolar Concentrations on Chromosome Damage Induced by Metabolically Activated Carcinogens in HepG2 Cells, 2021, Environmental Science & Technology
  • Human CYP2E1-dependent mutagenicity of benzene and its hydroxylated metabolites in V79-derived cells: Suppression and enhancement by ethanol pretreatment, 2020, Environmental and Molecular Mutagenesis
  • The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles, 2022, Scientific Reports
  • Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes, 2020, Archives of Toxicology
  • OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects, 2023, Archives of Toxicology

Frequent collaborators include Yungang Liu, Hang Yu, Meiqi Song, Keqi Hu, and Zihuan Li. The publication record features repeated contributions to journals such as Archives of Toxicology, Current Drug Metabolism, Environmental Science & Technology, Environmental and Molecular Mutagenesis, and Scientific Reports.

Best Publications

  • Sulfotransferases in the bioactivation of xenobiotics.

    Hansruedi Glatt

  • How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

    David Kirkland;Stefan Pfuhler;David Tweats;Marilyn Aardema

  • Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs

    Monique Kester;S. Bulduk;Dick Tibboel;W. Meinl

  • Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors

    Ernest V Curto;Cecil Kwong;Heino Hermersdörfer;Hansruedi Glatt

  • Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.

    Hansruedi Glatt;Heiner Boeing;Christina E.H Engelke;Lan Ma

  • The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.

    Emma Wincent;Nahid Amini;Sandra Luecke;Hansruedi Glatt

  • Vitamin E activates gene expression via the pregnane X receptor.

    Nico Landes;Paul Pfluger;Dirk Kluth;Marc Birringer

  • Interleukin-22 protects intestinal stem cells against genotoxic stress

    Konrad Gronke;Pedro P. Hernández;Pedro P. Hernández;Pedro P. Hernández;Jakob Zimmermann;Christoph S. N. Klose;Christoph S. N. Klose;Christoph S. N. Klose

  • Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation.

    Hansruedi Glatt

  • Identification and localization of soluble sulfotransferases in the human gastrointestinal tract.

    Wera Teubner;Walter Meinl;Simone Florian;Michael Kretzschmar

  • Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.

    Monique H. A. Kester;Sema Bulduk;Hans van Toor;Dick Tibboel

  • The apparent ubiquity of epoxide hydratase in rat organs

    Franz Oesch;Hansruedi Glatt;Hansueli Schmassmann

  • Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

    Johannes Doehmer;Satish Dogra;Thomas Friedberg;Solange Monier

  • V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals.

    Hansruedi Glatt;Heiko Schneider;Yungang Liu

  • Pharmacogenetics of soluble sulfotransferases (SULTs)

    Hansruedi Glatt;Walter Meinl

  • Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure

    T. Husøy;M. Haugen;M. Murkovic;D. Jöbstl

  • Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

    Volker M Arlt;Hansruedi Glatt;Eva Muckel;Ulrike Pabel

  • Mutagenicity of glutathione and cysteine in the Ames test.

    Hansruedi Glatt;Miroslava Protić-Sabljić;Franz Oesch

  • A rapid assay for epoxide hydratase activity with benzo(a)pyrene 4,5-(K-region-)oxide as substrate

    H.U. Schmassmann;H.R. Glatt;F. Oesch

  • Sulfotransferases: genetics and role in toxicology.

    Hansruedi Glatt;Christina E.H Engelke;Ulrike Pabel;Wera Teubner

Frequent Co-Authors

Franz Oesch
Franz Oesch Johannes Gutenberg University of Mainz
Albrecht Seidel
Albrecht Seidel Johannes Gutenberg University of Mainz
David H. Phillips
David H. Phillips King's College London
Michael W.H. Coughtrie
Michael W.H. Coughtrie University of British Columbia
Charles N. Falany
Charles N. Falany University of Alabama at Birmingham
Monika Schreiner
Monika Schreiner Leibniz Association
Jochanan Blum
Jochanan Blum Hebrew University of Jerusalem
Regina Brigelius-Flohé
Regina Brigelius-Flohé University of Potsdam
Robert Landsiedel
Robert Landsiedel BASF (United States)
Jan Alexander
Jan Alexander Norwegian Institute of Public Health

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