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Michael W.H. Coughtrie

Michael W.H. Coughtrie

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
9622
World Ranking
15179
National Ranking
535

Overview

Michael W.H. Coughtrie is affiliated with the University of British Columbia in Canada. Their academic contributions span the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Epidemiology, Immunology, Obstetrics and Gynecology, and Organic Chemistry.

The primary research topics affiliated with Coughtrie's work include:

  • Liver Disease Diagnosis and Treatment
  • Reproductive System and Pregnancy
  • Pregnancy and preeclampsia studies
  • Glycosylation and Glycoproteins Research
  • Biochemical and Molecular Research
  • Carbohydrate Chemistry and Synthesis
  • Pharmacogenetics and Drug Metabolism

The scientist has contributed to multiple research articles published in diverse venues:

  • "Homology Modeling of Human Uridine-5'-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding", 2020, ACS Omega
  • "Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation", 2020, European Journal of Drug Metabolism and Pharmacokinetics
  • "Detection and quantitation of non-steroidal anti-inflammatory drug use close to the time of birth using umbilical cord tissue", 2020, Toxicology Reports
  • "Protective placental inflammatory and oxidative stress responses are attenuated in the context of twin pregnancy and chorioamnionitis in assisted reproduction", 2022, Journal of Assisted Reproduction and Genetics
  • "Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences", 2023, Xenobiotica

Frequent co-authors collaborating with Michael W.H. Coughtrie include:

  • Abby C. Collier
  • Michael J. Doerksen
  • Alexander D. Smith
  • Robert S. Jones
  • Hayley R. Price

The research contributions are distributed across various publication venues, such as:

  • ACS Omega
  • European Journal of Drug Metabolism and Pharmacokinetics
  • Toxicology Reports
  • Journal of Assisted Reproduction and Genetics
  • Xenobiotica

Best Publications

  • Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine

    Christopher R. Ireson;Donald J. L. Jones;Samantha Orr;Michael W. H. Coughtrie

  • Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs

    Monique Kester;S. Bulduk;Dick Tibboel;W. Meinl

  • Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie”

    Zoe Riches;Emma L. Stanley;Jackie C. Bloomer;Michael W. H. Coughtrie

  • A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily.

    Rebecca L Blanchard;Robert R Freimuth;Jochen Buck;Richard M Weinshilboum

  • The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

    M. W. H. Coughtrie;B. Burchell;J. E. A. Leakey;R. Hume

  • Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases.

    Michael W.H Coughtrie;Sheila Sharp;Kaera Maxwell;Nicola P Innes

  • Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain.

    Kerry Richard;Robert Hume;Ellen Kaptein;Emma L. Stanley

  • Sulfation through the looking glass—recent advances in sulfotransferase research for the curious

    M W H Coughtrie

  • X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3 MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS DEMONSTRATE A MOLECULAR BASIS FOR SULFOTRANSFERASE SUBSTRATE SPECIFICITY

    Rana Dajani;Anne Cleasby;Margarete Neu;Alan J. Wonacott

  • Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.

    Monique H. A. Kester;Sema Bulduk;Hans van Toor;Dick Tibboel

  • Sulfotransferases: genetics and role in toxicology.

    Hansruedi Glatt;Christina E.H Engelke;Ulrike Pabel;Wera Teubner

  • Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations.

    Michael W. H. Coughtrie;Ron A. H. J. Gilissen;Benedicte Shek;Richard C. Strange

  • Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification.

    Emma L. Stanley;Robert Hume;Michael W.H. Coughtrie

  • Dopamine sulphate: an enigma resolved.

    G. Eisenhofer;M. W. H. Coughtrie;D. S. Goldstein

  • The enantioselective glucuronidation of morphine in rats and humans: Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

    Michael W.H. Coughtrie;Birgitta Ask;Anders Rane;Brian Burchell

  • Function and organization of the human cytosolic sulfotransferase (SULT) family.

    Michael W.H. Coughtrie

  • Estradiol formation by human osteoblasts via multiple pathways: Relation with osteoblast function

    J.M.M.F. Janssen;R. Bland;M. Hewison;M.W.H. Coughtrie

  • Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls

    A Gerlienke Schuur;Abraham Brouwer;Åke Bergman;Michael W.H Coughtrie

  • Characterization of Human Iodothyronine Sulfotransferases

    Monique H. A. Kester;Ellen Kaptein;Thirza J. Roest;Caren H. van Dijk

  • N-Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7

    Adam G. Staines;Michael W. H. Coughtrie;Brian Burchell

Frequent Co-Authors

Brian Burchell
Brian Burchell University of Dundee
Theo J. Visser
Theo J. Visser Erasmus University Rotterdam
Hansruedi Glatt
Hansruedi Glatt Federal Institute for Risk Assessment
Charles N. Falany
Charles N. Falany University of Alabama at Birmingham
Dick Tibboel
Dick Tibboel Erasmus University Rotterdam
John R. Bend
John R. Bend University of Western Ontario
Jacques Magdalou
Jacques Magdalou University of Lorraine
Patrick Netter
Patrick Netter University of Lorraine
Abraham Brouwer
Abraham Brouwer Vrije Universiteit Amsterdam
Åke Bergman
Åke Bergman Stockholm University

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