What is he best known for?
The fields of study he is best known for:
His primary areas of study are Biochemistry, Glucuronidation, UGT2B7, Pharmacology and Enzyme.
His Biochemistry study frequently draws parallels with other fields, such as Stereochemistry.
The various areas that Peter I. Mackenzie examines in his Glucuronidation study include Glucuronosyltransferase, Drug metabolism and In vivo.
His UGT2B7 research integrates issues from Human serum albumin, Albumin and Bovine serum albumin.
In the subject of general Enzyme, his work in Xenobiotic is often linked to Glucuronic acid, thereby combining diverse domains of study.
His study in the fields of UGT1A6 under the domain of Microsome overlaps with other disciplines such as Androsterone.
His most cited work include:
- The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (944 citations)
- Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (688 citations)
- STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES* (441 citations)
What are the main themes of his work throughout his whole career to date?
Biochemistry, Glucuronidation, Enzyme, Molecular biology and Pharmacology are his primary areas of study.
His is doing research in Isozyme, Metabolism, Amino acid, Cytochrome P450 and Peptide sequence, both of which are found in Biochemistry.
His Glucuronidation research is multidisciplinary, incorporating elements of Glucuronosyltransferase and Stereochemistry.
When carried out as part of a general Enzyme research project, his work on Substrate, Glycosyltransferase and Metabolic pathway is frequently linked to work in Glucuronic acid, therefore connecting diverse disciplines of study.
He studied Molecular biology and Promoter that intersect with Hepatocyte nuclear factors and Transcription.
His Pharmacology study integrates concerns from other disciplines, such as Cancer research, In vitro and In vivo.
He most often published in these fields:
- Biochemistry (47.64%)
- Glucuronidation (41.36%)
- Enzyme (20.94%)
What were the highlights of his more recent work (between 2016-2021)?
- Gene (15.71%)
- UDP Glucuronosyltransferase (8.38%)
- Cell biology (6.81%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Gene, UDP Glucuronosyltransferase, Cell biology, Cancer research and Biochemistry.
His UDP Glucuronosyltransferase research also works with subjects such as
- Breast cancer cells together with Prostate cancer, Downregulation and upregulation, Active metabolite and Exemestane,
- Cytochrome P450 3A which connect with Pharmacology.
Udp glycosyltransferase, SUPERFAMILY, Metabolite, Biotransformation and Xenobiotic are subfields of Biochemistry in which his conducts study.
His Oligomer research incorporates Function, Gene isoform, Enzyme and Glucuronidation.
His work on Cofactor is typically connected to Glucoside as part of general Enzyme study, connecting several disciplines of science.
His biological study spans a wide range of topics, including Breast cancer, Estrogen receptor and Androgen receptor.
Between 2016 and 2021, his most popular works were:
- Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia (40 citations)
- The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms (33 citations)
- Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure. (28 citations)
In his most recent research, the most cited papers focused on:
Peter I. Mackenzie spends much of his time researching Gene, Regulation of gene expression, Untranslated region, Alternative splicing and Molecular biology.
His Gene research incorporates elements of Signal transduction and Computational biology.
Regulation of gene expression is a primary field of his research addressed under Biochemistry.
His Untranslated region research is multidisciplinary, incorporating perspectives in Cell culture, Transfection, Mutation, Transcriptional regulation and Liver cancer.
His Alternative splicing study combines topics from a wide range of disciplines, such as Cell signaling, Human genome, Organism, Function and Glycosyltransferase.
In his work, CYP3A4, Extracellular and Drug metabolism is strongly intertwined with Messenger RNA, which is a subfield of Molecular biology.
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