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Peter I. Mackenzie

Peter I. Mackenzie

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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
19295
World Ranking
5081
National Ranking
121

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Peter I. Mackenzie is affiliated with Flinders University in Australia, focusing on research within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their scholarly contributions cover multiple subfields, including Molecular Biology, Pharmacology, Cancer Research, Biochemistry, and Oncology.

Their research spans a range of topics, most notably Pharmacogenetics and Drug Metabolism, Glycosylation and Glycoproteins Research, Drug Transport and Resistance Mechanisms, Epigenetics and DNA Methylation, RNA modifications and cancer, Amino Acid Enzymes and Metabolism, and Neonatal Health and Biochemistry.

Peter I. Mackenzie has coauthored publications frequently with several collaborators. Key coauthors include Robyn Meech, Julie-Ann Hulin, Dong Hu, Ross A. McKinnon, and Yuu Miyauchi.

Their recent publications illustrate a focus on UDP-glycosyltransferase (UGT) genes and their role in human cancers and metabolic processes. Recent papers include:

  • The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes (2020, Cancers)
  • The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes (2021, Cancers)
  • Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT (2020, Biochemical and Biophysical Research Communications)
  • Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs (2022, Drug Metabolism Reviews)
  • Circular RNAs of UDP-Glycosyltransferase (UGT) Genes Expand the Complexity and Diversity of the UGT Transcriptome (2021, Molecular Pharmacology)

Their work has appeared predominantly in journals such as Cancers, Drug Metabolism and Pharmacokinetics, Practice Management, arXiv (Cornell University), and Biochemical and Biophysical Research Communications.

Best Publications

  • The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

    Peter I. Mackenzie;Ida S. Owens;Brian Burchell;K. W. Bock

  • Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

    Peter I Mackenzie;Karl Walter Bock;Brian Burchell;Chantal Guillemette

  • The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.

    Andrew Rowland;John Oliver Miners;Peter Ian Mackenzie

  • STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*

    Anna Radominska-Pandya;Piotr J. Czernik;Joanna M. Little;Eric Battaglia

  • HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID

    Verawan Uchaipichat;Peter I. Mackenzie;Xiao-Hui Guo;Xiao-Hui Guo;Dione Gardner-Stephen

  • The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.

    Brian Burchell;Daniel W. Nebert;David R. Nelson;Karl W. Bock

  • STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES

    Robyn Meech;Peter I. Mackenzie

  • SELECTIVITY OF SUBSTRATE (TRIFLUOPERAZINE) AND INHIBITOR (AMITRIPTYLINE, ANDROSTERONE, CANRENOIC ACID, HECOGENIN, PHENYLBUTAZONE, QUINIDINE, QUININE, AND SULFINPYRAZONE) “PROBES” FOR HUMAN UDP-GLUCURONOSYLTRANSFERASES

    Verawan Nu Uchaipichat;Peter Ian Mackenzie;David John Elliot;John Oliver Miners

  • Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3

    Mitchell D. Green;Christopher D. King;Behnaz Mojarrabi;Peter I. Mackenzie

  • Glucuronidation and the UDP-glucuronosyltransferases in health and disease

    Peter G. Wells;Peter I. Mackenzie;Jayanta Roy Chowdhury;Chantal Guillemette

  • The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential.

    John Oliver Miners;Peter Ian Mackenzie;Kathleen Mary Knights

  • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

    Michael H. Court;Su X. Duan;Lisa L. von Moltke;David J. Greenblatt

  • Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

    Chunjing Jin;J. O. Miners;K. J. Lillywhite;P. I. Mackenzie

  • Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance

    John O Miners;Ross A McKinnon;Peter I Mackenzie

  • The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.

    Robyn Meech;Dong Gui Hu;Ross A. McKinnon;Siti Nurul Mubarokah

  • In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

    John Oliver Miners;Kathleen Mary Knights;J Brian Houston;Peter Ian Mackenzie

  • Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.

    Maurice E. Veronese;Peter I. Mackenzie;Christopher J. Doecke;Michael E. McManus

  • In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction

    Andrew Rowland;David John Elliot;Andrew Williams;Peter Ian Mackenzie

  • Predicting Human Drug Glucuronidation Parameters: Application of In Vitro and In Silico Modeling Approaches

    John O Miners;Paul A Smith;Michael J Sorich;Ross A McKinnon

  • ISOFORM SELECTIVITY AND KINETICS OF MORPHINE 3- AND 6-GLUCURONIDATION BY HUMAN UDP-GLUCURONOSYLTRANSFERASES: EVIDENCE FOR ATYPICAL GLUCURONIDATION KINETICS BY UGT2B7

    Andrew N. Stone;Peter I. Mackenzie;Aleksandra Galetin;J. Brian Houston

Frequent Co-Authors

John O. Miners
John O. Miners Flinders University
Yasushi Yamazoe
Yasushi Yamazoe Tohoku University
Anne Rogers
Anne Rogers University of Southampton
Thomas R. Tephly
Thomas R. Tephly University of Iowa
J. Brian Houston
J. Brian Houston University of Manchester
Wayne D. Tilley
Wayne D. Tilley University of Adelaide
Moshe Finel
Moshe Finel University of Helsinki
Brian Burchell
Brian Burchell University of Dundee
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati

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