His primary areas of study are Biochemistry, Glucuronidation, UGT2B7, Pharmacology and Enzyme. His Biochemistry study frequently draws parallels with other fields, such as Stereochemistry. The various areas that Peter I. Mackenzie examines in his Glucuronidation study include Glucuronosyltransferase, Drug metabolism and In vivo.
His UGT2B7 research integrates issues from Human serum albumin, Albumin and Bovine serum albumin. In the subject of general Enzyme, his work in Xenobiotic is often linked to Glucuronic acid, thereby combining diverse domains of study. His study in the fields of UGT1A6 under the domain of Microsome overlaps with other disciplines such as Androsterone.
Biochemistry, Glucuronidation, Enzyme, Molecular biology and Pharmacology are his primary areas of study. His is doing research in Isozyme, Metabolism, Amino acid, Cytochrome P450 and Peptide sequence, both of which are found in Biochemistry. His Glucuronidation research is multidisciplinary, incorporating elements of Glucuronosyltransferase and Stereochemistry.
When carried out as part of a general Enzyme research project, his work on Substrate, Glycosyltransferase and Metabolic pathway is frequently linked to work in Glucuronic acid, therefore connecting diverse disciplines of study. He studied Molecular biology and Promoter that intersect with Hepatocyte nuclear factors and Transcription. His Pharmacology study integrates concerns from other disciplines, such as Cancer research, In vitro and In vivo.
His scientific interests lie mostly in Gene, UDP Glucuronosyltransferase, Cell biology, Cancer research and Biochemistry. His UDP Glucuronosyltransferase research also works with subjects such as
His Oligomer research incorporates Function, Gene isoform, Enzyme and Glucuronidation. His work on Cofactor is typically connected to Glucoside as part of general Enzyme study, connecting several disciplines of science. His biological study spans a wide range of topics, including Breast cancer, Estrogen receptor and Androgen receptor.
Peter I. Mackenzie spends much of his time researching Gene, Regulation of gene expression, Untranslated region, Alternative splicing and Molecular biology. His Gene research incorporates elements of Signal transduction and Computational biology. Regulation of gene expression is a primary field of his research addressed under Biochemistry.
His Untranslated region research is multidisciplinary, incorporating perspectives in Cell culture, Transfection, Mutation, Transcriptional regulation and Liver cancer. His Alternative splicing study combines topics from a wide range of disciplines, such as Cell signaling, Human genome, Organism, Function and Glycosyltransferase. In his work, CYP3A4, Extracellular and Drug metabolism is strongly intertwined with Messenger RNA, which is a subfield of Molecular biology.
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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Peter I. Mackenzie;Ida S. Owens;Brian Burchell;K. W. Bock.
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Peter I Mackenzie;Karl Walter Bock;Brian Burchell;Chantal Guillemette.
Pharmacogenetics and Genomics (2005)
STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
Anna Radominska-Pandya;Piotr J. Czernik;Joanna M. Little;Eric Battaglia.
Drug Metabolism Reviews (1999)
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.
Andrew Rowland;John Oliver Miners;Peter Ian Mackenzie.
The International Journal of Biochemistry & Cell Biology (2013)
HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID
Verawan Uchaipichat;Peter I. Mackenzie;Xiao-Hui Guo;Xiao-Hui Guo;Dione Gardner-Stephen.
Drug Metabolism and Disposition (2004)
Drug glucuronidation in humans.
John O. Miners;Peter I. Mackenzie.
Pharmacology & Therapeutics (1991)
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.
Brian Burchell;Daniel W. Nebert;David R. Nelson;Karl W. Bock.
DNA and Cell Biology (1991)
SELECTIVITY OF SUBSTRATE (TRIFLUOPERAZINE) AND INHIBITOR (AMITRIPTYLINE, ANDROSTERONE, CANRENOIC ACID, HECOGENIN, PHENYLBUTAZONE, QUINIDINE, QUININE, AND SULFINPYRAZONE) “PROBES” FOR HUMAN UDP-GLUCURONOSYLTRANSFERASES
Verawan Nu Uchaipichat;Peter Ian Mackenzie;David John Elliot;John Oliver Miners.
Drug Metabolism and Disposition (2006)
Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
Mitchell D. Green;Christopher D. King;Behnaz Mojarrabi;Peter I. Mackenzie.
Drug Metabolism and Disposition (1998)
STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES
Robyn Meech;Peter I. Mackenzie.
Clinical and Experimental Pharmacology and Physiology (1997)
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