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Medicine

D-Index
75
Citations
18910
World Ranking
19175
National Ranking
1731

Overview

J. Brian Houston is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Medicine and Pharmacology, Toxicology and Pharmaceutics, focusing on areas such as Pharmacology, Oncology, Computational Theory and Mathematics, Pediatrics, Perinatology and Child Health, and Spectroscopy.

The scientist's work centers around key topics including Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Computational Drug Discovery Methods, Pharmacological Effects and Toxicity Studies, Analytical Chemistry and Chromatography, Pesticide Exposure and Toxicity, and Environmental Toxicology and Ecotoxicology.

Recent publications authored or co-authored by J. Brian Houston include the following:

  • Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation, 2020, Drug Metabolism and Disposition
  • Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates, 2024, CPT Pharmacometrics & Systems Pharmacology
  • Exploring the Boundaries for In Vitro-In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types, 2023, Drug Metabolism and Disposition
  • Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol, 2020, Xenobiotica
  • Bringing totality-of-evidence into PBPK predictions: fraction metabolised by aldehyde oxidase, 2024, Drug Metabolism and Pharmacokinetics

Their frequent co-authors include Laura Francis, David Hallifax, Nihan Izat, Jill Barber, and Aleksandra Galetin.

J. Brian Houston's research has been published predominantly in the following venues:

  • Drug Metabolism and Disposition
  • CPT Pharmacometrics & Systems Pharmacology
  • Xenobiotica
  • Drug Metabolism and Pharmacokinetics

Best Publications

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

    R. Scott Obach;Robert L. Walsky;Karthik Venkatakrishnan;Emily A. Gaman

  • HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID

    Verawan Uchaipichat;Peter I. Mackenzie;Xiao-Hui Guo;Xiao-Hui Guo;Dione Gardner-Stephen

  • Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus.

    Geoffrey T. Tucker;J. Brian Houston;Shiew Mei Huang

  • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

    Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  • Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

    J. Brian Houston;David J. Carlile

  • Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus.

    Geoffrey T. Tucker;Geoffrey T. Tucker;Geoffrey T. Tucker;J. Brian Houston;J. Brian Houston;J. Brian Houston;Shiew‐Mei Huang;Shiew‐Mei Huang;Shiew‐Mei Huang

  • Database analyses for the prediction of in vivo drug–drug interactions from in vitro data

    Kiyomi Ito;Hayley S. Brown;J. Brian Houston

  • Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Michael Gertz;Anthony Harrison;J. Brian Houston;Aleksandra Galetin

  • Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

    Kiyomi Ito;J. Brian Houston

  • In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

    John Oliver Miners;Kathleen Mary Knights;J Brian Houston;Peter Ian Mackenzie

  • Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Kiyomi Ito;J. Brian Houston

  • Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

    Hannah M. Jones;Hugh A. Barton;Yurong Lai;Yi An Bi

  • Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

    Hayley S. Brown;Michael Griffin;J. Brian Houston

  • ISOFORM SELECTIVITY AND KINETICS OF MORPHINE 3- AND 6-GLUCURONIDATION BY HUMAN UDP-GLUCURONOSYLTRANSFERASES: EVIDENCE FOR ATYPICAL GLUCURONIDATION KINETICS BY UGT2B7

    Andrew N. Stone;Peter I. Mackenzie;Aleksandra Galetin;J. Brian Houston

  • Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

    Peter J. Kilford;Rowan Stringer;Bindi Sohal;J. Brian Houston

  • Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

    David Hallifax;Joanne A. Foster;J. Brian Houston

  • Multisite Kinetic Models for CYP3A4: Simultaneous Activation and Inhibition of Diazepam and Testosterone Metabolism

    Kathryn E. Kenworthy;Stephen E. Clarke;Julie Andrews;J. Brian Houston

  • BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT

    David Hallifax;J. Brian Houston

Frequent Co-Authors

Peter I. Mackenzie
Peter I. Mackenzie Flinders University
John O. Miners
John O. Miners Flinders University
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
R. Scott Obach
R. Scott Obach Pfizer (United States)
Malcolm Rowland
Malcolm Rowland University of Manchester
Brian G. Lake
Brian G. Lake University of Surrey
Patrick Maurel
Patrick Maurel University of Montpellier
Edward L. LeCluyse
Edward L. LeCluyse Research Triangle Park Foundation
Per Artursson
Per Artursson Uppsala University
Albert P. Li
Albert P. Li Washington University in St. Louis

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