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J. Brian Houston

D-Index & Metrics

Medicine

D-Index
75
Citations
18910
World Ranking
19175
National Ranking
1731

J. Brian Houston publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where J. Brian Houston sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 611 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 199 publications — 2nd percentile

2% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

J. Brian Houston D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where J. Brian Houston sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 400 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 75 D-Index — 6th percentile

6% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Overview

J. Brian Houston is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the fields of Medicine and Pharmacology, Toxicology and Pharmaceutics, focusing on areas such as Pharmacology, Oncology, Computational Theory and Mathematics, Pediatrics, Perinatology and Child Health, and Spectroscopy.

The scientist's work centers around key topics including Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Computational Drug Discovery Methods, Pharmacological Effects and Toxicity Studies, Analytical Chemistry and Chromatography, Pesticide Exposure and Toxicity, and Environmental Toxicology and Ecotoxicology.

Recent publications authored or co-authored by J. Brian Houston include the following:

  • Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation, 2020, Drug Metabolism and Disposition
  • Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates, 2024, CPT Pharmacometrics & Systems Pharmacology
  • Exploring the Boundaries for In Vitro-In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types, 2023, Drug Metabolism and Disposition
  • Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol, 2020, Xenobiotica
  • Bringing totality-of-evidence into PBPK predictions: fraction metabolised by aldehyde oxidase, 2024, Drug Metabolism and Pharmacokinetics

Their frequent co-authors include Laura Francis, David Hallifax, Nihan Izat, Jill Barber, and Aleksandra Galetin.

J. Brian Houston's research has been published predominantly in the following venues:

  • Drug Metabolism and Disposition
  • CPT Pharmacometrics & Systems Pharmacology
  • Xenobiotica
  • Drug Metabolism and Pharmacokinetics

Best Publications

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

    R. Scott Obach;Robert L. Walsky;Karthik Venkatakrishnan;Emily A. Gaman

  • HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID

    Verawan Uchaipichat;Peter I. Mackenzie;Xiao-Hui Guo;Xiao-Hui Guo;Dione Gardner-Stephen

  • Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus.

    Geoffrey T. Tucker;J. Brian Houston;Shiew Mei Huang

  • Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

    Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  • Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

    J. Brian Houston;David J. Carlile

  • Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus.

    Geoffrey T. Tucker;Geoffrey T. Tucker;Geoffrey T. Tucker;J. Brian Houston;J. Brian Houston;J. Brian Houston;Shiew‐Mei Huang;Shiew‐Mei Huang;Shiew‐Mei Huang

  • Database analyses for the prediction of in vivo drug–drug interactions from in vitro data

    Kiyomi Ito;Hayley S. Brown;J. Brian Houston

  • Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

    Michael Gertz;Anthony Harrison;J. Brian Houston;Aleksandra Galetin

  • Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

    Kiyomi Ito;J. Brian Houston

  • In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

    John Oliver Miners;Kathleen Mary Knights;J Brian Houston;Peter Ian Mackenzie

  • Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

    Kiyomi Ito;J. Brian Houston

  • Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

    Hannah M. Jones;Hugh A. Barton;Yurong Lai;Yi An Bi

  • Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

    Hayley S. Brown;Michael Griffin;J. Brian Houston

  • ISOFORM SELECTIVITY AND KINETICS OF MORPHINE 3- AND 6-GLUCURONIDATION BY HUMAN UDP-GLUCURONOSYLTRANSFERASES: EVIDENCE FOR ATYPICAL GLUCURONIDATION KINETICS BY UGT2B7

    Andrew N. Stone;Peter I. Mackenzie;Aleksandra Galetin;J. Brian Houston

  • Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

    Peter J. Kilford;Rowan Stringer;Bindi Sohal;J. Brian Houston

  • Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

    David Hallifax;Joanne A. Foster;J. Brian Houston

  • Multisite Kinetic Models for CYP3A4: Simultaneous Activation and Inhibition of Diazepam and Testosterone Metabolism

    Kathryn E. Kenworthy;Stephen E. Clarke;Julie Andrews;J. Brian Houston

  • BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT

    David Hallifax;J. Brian Houston

Frequent Co-Authors

Peter I. Mackenzie
Peter I. Mackenzie Flinders University
John O. Miners
John O. Miners Flinders University
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
R. Scott Obach
R. Scott Obach Pfizer (United States)
Malcolm Rowland
Malcolm Rowland University of Manchester
Brian G. Lake
Brian G. Lake University of Surrey
Patrick Maurel
Patrick Maurel University of Montpellier
Edward L. LeCluyse
Edward L. LeCluyse Research Triangle Park Foundation
Per Artursson
Per Artursson Uppsala University
Albert P. Li
Albert P. Li Washington University in St. Louis

External Links

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Best Scientists Citing J. Brian Houston

Amin Rostami-Hodjegan

Amin Rostami-Hodjegan

University of Manchester

Publications: 118

John O. Miners

John O. Miners

Flinders University

Publications: 73

Jan G. Hengstler

Jan G. Hengstler

TU Dortmund University

Publications: 71

Yuichi Sugiyama

Yuichi Sugiyama

University of Tokyo

Publications: 58

Peter I. Mackenzie

Peter I. Mackenzie

Flinders University

Publications: 47

R. Scott Obach

R. Scott Obach

Pfizer (United States)

Publications: 45

Guang-Bo Ge

Guang-Bo Ge

Shanghai University

Publications: 36

Li Di

Li Di

Pfizer (United States)

Publications: 35

Tommy B. Andersson

Tommy B. Andersson

AstraZeneca (United Kingdom)

Publications: 34

Per Artursson

Per Artursson

Uppsala University

Publications: 32

Ivonne M.C.M. Rietjens

Ivonne M.C.M. Rietjens

Wageningen University & Research

Publications: 30

David J. Greenblatt

David J. Greenblatt

Tufts University

Publications: 28

Malcolm Rowland

Malcolm Rowland

University of Manchester

Publications: 27

Kim L. R. Brouwer

Kim L. R. Brouwer

University of North Carolina at Chapel Hill

Publications: 26

Hans Lennernäs

Hans Lennernäs

Uppsala University

Publications: 25

Andreas K. Nussler

Andreas K. Nussler

University of Tübingen

Publications: 24

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