World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
57
Citations
15034
World Ranking
10950
National Ranking
3001

Overview

Li Di is a researcher affiliated with Pfizer in the United States, with a primary focus on medicine and related subfields including neurology, pharmacology, molecular biology, oncology, and infectious diseases. Their body of work spans multiple aspects of drug metabolism, pharmacokinetics, and infectious disease research.

The scientist's recent publications cover several important topics in biomedical research. Key papers include:

  • An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19, 2021, Science
  • Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development, 2022, Pharmaceutical Research
  • Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development, 2022, Acta Pharmaceutica Sinica B
  • Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans, 2022, Drug Metabolism and Disposition

Li Di frequently collaborates with a network of coauthors, including Yuwei Da, Yan Lü, David A. Tess, Anthony Carlo, and Xinmei Wen. These collaborations have contributed to the development and dissemination of research across their fields of interest.

Their research has been published predominantly in several key scientific venues. These include:

  • The AAPS Journal
  • Drug Metabolism and Pharmacokinetics
  • Journal of Medicinal Chemistry
  • Pharmaceutical Research
  • Journal of Pharmaceutical Sciences

Li Di's principal topics of research cover areas such as pharmacogenetics and drug metabolism, drug transport and resistance mechanisms, computational drug discovery methods, and clinical research related to COVID-19. Other notable topics include protein interaction studies and diseases such as myasthenia gravis and thymoma.

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Computational Drug Discovery Methods
  • Myasthenia Gravis and Thymoma
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Protein Interaction Studies and Fluorescence Analysis

Best Publications

  • The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

    Dennis A. Smith;Li Di;Edward H. Kerns

  • Coexistence of passive and carrier-mediated processes in drug transport

    Kiyohiko Sugano;Manfred Kansy;Per Artursson;Alex Avdeef

  • Strategic approaches to optimizing peptide ADME properties.

    Li Di

  • Bridging solubility between drug discovery and development.

    Li Di;Paul V. Fish;Takashi Mano

  • Demystifying brain penetration in central nervous system drug discovery. Miniperspective.

    Li Di;Haojing Rong;Bo Feng

  • Profiling drug-like properties in discovery research

    Li Di;Edward H Kerns

  • Pharmaceutical profiling in drug discovery.

    Edward H Kerns;Li Di

  • Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery.

    Edward H. Kerns;Li Di;Susan Petusky;Michele Farris

  • Volume of Distribution in Drug Design

    Dennis A. Smith;Kevin Beaumont;Tristan S. Maurer;Li Di

  • Development of a new permeability assay using low-efflux MDCKII cells

    Li Di;Carrie Whitney‐Pickett;John P. Umland;Hui Zhang

  • PAMPA--critical factors for better predictions of absorption.

    Alex Avdeef;Stefanie Bendels;L.i. Di;Bernard Faller

  • Development and application of high throughput plasma stability assay for drug discovery

    Li Di;Edward H. Kerns;Yan Hong;Hong Chen

  • The role of drug metabolizing enzymes in clearance

    Unknown

  • Biological assay challenges from compound solubility: strategies for bioassay optimization

    Li Di;Edward H. Kerns

  • Species Independence in Brain Tissue Binding Using Brain Homogenates

    Li Di;John P Umland;George C Chang;Youping Huang

  • The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics

    Li Di

  • Relevance of Half-Life in Drug Design

    Dennis A. Smith;Kevin Beaumont;Tristan S. Maurer;Li Di

  • Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging.

    Heather E. Murrey;Joshua C. Judkins;Christopher W. am Ende;T. Eric Ballard

  • Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

    Li Di;Per Artursson;Alex Avdeef;Gerhard F. Ecker

  • Clearance in Drug Design

    Dennis A Smith;Kevin Beaumont;Tristan S Maurer;Li Di

  • pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

    Manthena V. Varma;Iain Gardner;Stefanus J. Steyn;Paul Nkansah

  • Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates.

    Li Di;Edward H Kerns;Yan Hong;Teresa A Kleintop

  • Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

    Li Di;Christopher Keefer;Dennis O. Scott;Timothy J. Strelevitz

Frequent Co-Authors

R. Scott Obach
R. Scott Obach Pfizer (United States)
Amit S. Kalgutkar
Amit S. Kalgutkar Pfizer (United States)
Lee E. Schechter
Lee E. Schechter Princeton University
Jeffrey A. Pfefferkorn
Jeffrey A. Pfefferkorn Pfizer (United States)
Alex Avdeef
Alex Avdeef in-ADME Research
Per Artursson
Per Artursson Uppsala University
Hans Lennernäs
Hans Lennernäs Uppsala University
Tarek S. Mansour
Tarek S. Mansour Pfizer (United States)
J. Brian Houston
J. Brian Houston University of Manchester
Annaliesa S. Anderson
Annaliesa S. Anderson Pfizer (United States)

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