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Overview

Marcel Kaiser is affiliated with the Swiss Tropical and Public Health Institute in Switzerland. Their research primarily spans the fields of Medicine, Chemistry, and Biochemistry, Genetics and Molecular Biology, with notable contributions to Organic Chemistry, Public Health, Environmental and Occupational Health, Molecular Biology, Epidemiology, and Plant Science.

The scientist focuses extensively on the study of Trypanosoma species and their implications, as well as research on Leishmaniasis. Other key topics in their work include synthesis and biological evaluation, traditional and medicinal uses of Annonaceae, synthesis and biological activity, biochemical and molecular research, and malaria research and control.

Marcel Kaiser has published papers in several frequently appearing scientific venues, including:

  • Molecules
  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database

Some of their recent papers are:

  • "Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors," 2020, Nature Microbiology
  • "Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership," 2022, Diseases
  • "Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections," 2023, Science
  • "Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles," 2021, European Journal of Medicinal Chemistry
  • "HPLC-Based Activity Profiling for Antiprotozoal Compounds in Croton gratissimus and Cuscuta hyalina," 2020, Frontiers in Pharmacology

Throughout their scientific career, Marcel Kaiser has collaborated frequently with several researchers, including:

  • Pascal Mäser
  • Monica Cal
  • Werner Seebacher
  • Robert Weis
  • Thomas J. Schmidt

Best Publications

  • Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies

    Deniz Tasdemir;Marcel Kaiser;Reto Brun;Vanessa Yardley

  • Experimental evolution of aging, growth, and reproduction in fruitflies

    S. C. Stearns;M. Ackermann;M. Doebeli;M. Kaiser

  • Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

    Els Torreele;Bernadette Bourdin Trunz;David Tweats;David Tweats;Marcel Kaiser;Marcel Kaiser

  • SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

    Robert T. Jacobs;Bakela Nare;Stephen A. Wring;Matthew D. Orr

  • Inhibitory Activity of Marine Sponge-Derived Natural Products against Parasitic Protozoa

    Ilkay Orhan;Bilge Şener;Marcel Kaiser;Reto Brun

  • Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness

    Marcel Kaiser;Marcel Kaiser;Michael A. Bray;Monica Cal;Monica Cal;Bernadette Bourdin Trunz

  • DMSO‐Mediated Ligand Dissociation: Renaissance for Biological Activity of N‐Heterocyclic‐[Ru(η6‐arene)Cl2] Drug Candidates

    Malay Patra;Tanmaya Joshi;Vanessa Pierroz;Katrin Ingram

  • The differential genetic and environmental canalization of fitness components in Drosophila melanogaster

    Stephen C. Stearns;Marcel Kaiser;Tadeusz J. Kawecki

  • Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation

    Cyril Portmann;Judith F. Blom;Marcel Kaiser;Reto Brun

  • Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.

    Sabine Van Miert;Steven Hostyn;Bert U. W. Maes;Kanyanga Cimanga

  • Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones

    Thomas J. Schmidt;Amal M. M. Nour;Sami A. Khalid;Marcel Kaiser

  • Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

    Fabrice E. Graf;Philipp Ludin;Philipp Ludin;Tanja Wenzler;Tanja Wenzler;Marcel Kaiser;Marcel Kaiser

  • Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.

    Marcel Kaiser;Pascal Mäser;Leela Pavan Tadoori;Jean-Robert Ioset

  • Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis.

    María Salomé Gachet;Javier Salazar Lecaro;Marcel Kaiser;Reto Brun

  • Antimalarial Pyrido[1,2-a]benzimidazoles

    Albert J. Ndakala;Richard K. Gessner;Patricia W. Gitari;Natasha October

  • Analogues of Thiolactomycin as Potential Antimalarial Agents

    Simon M. Jones;Jonathan E. Urch;Marcel Kaiser;Reto Brun

  • Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.

    Maria V. Papadopoulou;William D. Bloomer;Howard S. Rosenzweig;Eric Chatelain

  • Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites

    Fernando Scala;Ernesto Fattorusso;Marialuisa Menna;Orazio Taglialatela-Scafati

  • The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L

    Amal M.M. Nour;Sami A. Khalid;Marcel Kaiser;Reto Brun

  • Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica.

    Sylvian Cretton;Lise Breant;Lucie Pourrez;Chiara Ambuehl

  • New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.

    Fernando Rodríguez;Isabel Rozas;Marcel Kaiser;Reto Brun

Frequent Co-Authors

Reto Brun
Reto Brun University of Basel
Pascal Mäser
Pascal Mäser Swiss Tropical and Public Health Institute
Matthias Hamburger
Matthias Hamburger University of Basel
Helge B. Bode
Helge B. Bode Goethe University Frankfurt
Ian H. Gilbert
Ian H. Gilbert University of Dundee
Gerhard Bringmann
Gerhard Bringmann University of Würzburg
J. B. Hutchings
J. B. Hutchings National Research Council Canada
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
R. Luise Krauth-Siegel
R. Luise Krauth-Siegel Heidelberg University
Brent R. Copp
Brent R. Copp University of Auckland

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