D-Index & Metrics Best Publications
Biology and Biochemistry
Switzerland
2023
Chemistry
Switzerland
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 83 Citations 22,306 485 World Ranking 1742 National Ranking 35
Biology and Biochemistry D-index 92 Citations 31,290 551 World Ranking 1420 National Ranking 33

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

2023 - Research.com Chemistry in Switzerland Leader Award

Overview

What is he best known for?

The fields of study Reto Brun is best known for:

  • Enzyme
  • DNA
  • Gene

Reto Brun works mostly in the field of Pharmacokinetics, limiting it down to topics relating to Pharmacology and, in certain cases, Drug, as a part of the same area of interest. While working on this project, Reto Brun studies both Drug and Pharmacology. Antiprotozoal, Biological activity and Cytotoxicity are closely tied to his In vitro research. Reto Brun integrates Biochemistry and Microbiology in his research. In his research, Reto Brun performs multidisciplinary study on Microbiology and Biochemistry. He conducts interdisciplinary study in the fields of Immunology and Pathology through his works. Reto Brun combines Pathology and Immunology in his research. Reto Brun performs integrative study on Gene and Genetics. He performs integrative Genetics and Gene research in his work.

His most cited work include:

  • Spiroindolones, a Potent Compound Class for the Treatment of Malaria (992 citations)
  • Human African trypanosomiasis (752 citations)
  • Antimalarial drug discovery: efficacy models for compound screening (670 citations)

What are the main themes of his work throughout his whole career to date

Reto Brun is investigating In vitro as part of his inquiry into Antiprotozoal, Cytotoxicity and IC50. Reto Brun performs multidisciplinary study in the fields of Biochemistry and Microbiology via his papers. In his research, Reto Brun undertakes multidisciplinary study on Microbiology and Biochemistry. In his study, Reto Brun carries out multidisciplinary Stereochemistry and Organic chemistry research. While working in this field, Reto Brun studies both Organic chemistry and Stereochemistry. His study connects Trypanosoma brucei rhodesiense and Immunology. His research brings together the fields of Immunology and Trypanosoma brucei rhodesiense. He performs multidisciplinary studies into Gene and Enzyme in his work. Reto Brun connects Enzyme with Gene in his research.

Reto Brun most often published in these fields:

  • Biochemistry (76.60%)
  • In vitro (57.66%)
  • Stereochemistry (56.60%)

What were the highlights of his more recent work (between 2014-2021)?

  • Biochemistry (77.05%)
  • Stereochemistry (63.93%)
  • In vitro (59.02%)

In recent works Reto Brun was focusing on the following fields of study:

His Alkaloid research focuses on Stereochemistry and how it connects with Tetrahydroisoquinoline. His Tetrahydroisoquinoline study often links to related topics such as Stereochemistry. The In vitro portion of his research involves studies in Antiprotozoal, Cytotoxicity, IC50 and Biological activity. Cytotoxicity is closely attributed to In vitro in his work. His research on Biochemistry frequently connects to adjacent areas such as Antiprotozoal. Reto Brun connects Gene with Enzyme in his study. With his scientific publications, his incorporates both Enzyme and Gene. His research brings together the fields of Trypanosoma brucei rhodesiense and Immunology. Trypanosoma brucei rhodesiense is closely attributed to Immunology in his study.

Between 2014 and 2021, his most popular works were:

  • Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning (71 citations)
  • Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese LianaAncistrocladus ileboensiswith Potent Activities againstPlasmodium falciparumand against Multiple Myeloma and Leukemia Cell Lines (54 citations)
  • Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity (42 citations)

In his most recent research, the most cited works focused on:

  • Enzyme
  • Malaria
  • Organic chemistry

In his research, Alkaloid is intimately related to Botany, which falls under the overarching field of Liana. His Botany research extends to the thematically linked field of Alkaloid. His Stereochemistry study frequently links to related topics such as Isoquinoline. His Isoquinoline study often links to related topics such as Stereochemistry. Many of his studies on Biochemistry involve topics that are commonly interrelated, such as Biological activity. His research on Biological activity often connects related topics like In vitro. His research brings together the fields of Antiprotozoal and In vitro. His Antiprotozoal study often links to related topics such as Biochemistry. Pharmacology and Pathology are two areas of study in which Reto Brun engages in interdisciplinary work.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Matthias Rottmann;Matthias Rottmann;Case McNamara;Bryan K.S. Yeung;Marcus C.S. Lee.
Science (2010)

1098 Citations

Antimalarial drug discovery: efficacy models for compound screening

David A. Fidock;Philip J. Rosenthal;Simon L. Croft;Reto Brun.
Nature Reviews Drug Discovery (2004)

1082 Citations

Human African trypanosomiasis

Reto Brun;Johannes Blum;Francois Chappuis;Francois Chappuis;Christian Burri.
The Lancet (2010)

986 Citations

The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

B Räz;M Iten;Y Grether-Bühler;R Kaminsky.
Acta Tropica (1997)

963 Citations

Identification of an antimalarial synthetic trioxolane drug development candidate.

Jonathan L Vennerstrom;Sarah Arbe-Barnes;Reto Brun;Susan A Charman.
Nature (2004)

741 Citations

Kinetoplastids: related protozoan pathogens, different diseases

Ken Stuart;Reto Brun;Simon Croft;Alan Fairlamb.
Journal of Clinical Investigation (2008)

645 Citations

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Susan A. Charman;Sarah Arbe-Barnes;Ian C. Bathurst;Reto Brun.
Proceedings of the National Academy of Sciences of the United States of America (2011)

410 Citations

Spirotetrahydro β-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

Bryan K S Yeung;Bin Zou;Matthias Rottmann;Suresh B Lakshminarayana.
Journal of Medicinal Chemistry (2010)

409 Citations

Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies

Deniz Tasdemir;Marcel Kaiser;Reto Brun;Vanessa Yardley.
Antimicrobial Agents and Chemotherapy (2006)

363 Citations

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I

T. J. Schmidt;S. A. Khalid;A. J. Romanha;T. Ma. Alves.
Current Medicinal Chemistry (2012)

318 Citations

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