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Susan A. Charman

Susan A. Charman

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
17989
World Ranking
6649
National Ranking
162

Overview

Susan A. Charman is affiliated with Monash University in Australia. Their research portfolio encompasses a wide range of studies in medicine and biochemistry, genetics, and molecular biology. The main scientific areas of focus include public health, environmental and occupational health, molecular biology, organic chemistry, infectious diseases, and computational theory and mathematics.

The research topics central to their work cover malaria research and control, computational drug discovery methods, research on leishmaniasis studies, HIV/AIDS drug development and treatment, parasites and host interactions, Trypanosoma species research and implications, and mosquito-borne diseases and control.

Notable recent papers authored or co-authored by Susan A. Charman include:

  • An in vitro toolbox to accelerate anti-malarial drug discovery and development, 2020, Malaria Journal
  • Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer, 2023, Cell chemical biology
  • Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors, 2022, Frontiers in Chemistry
  • Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series, 2021, Journal of Medicinal Chemistry
  • Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans, 2020, Frontiers in Physiology

Susan A. Charman has frequently published in journals such as the Journal of Medicinal Chemistry, ACS Infectious Diseases, bioRxiv (Cold Spring Harbor Laboratory), Malaria Journal, and Cell chemical biology.

Frequent collaborators of Susan A. Charman include:

  • David M. Shackleford
  • Karen L. White
  • Kasiram Katneni
  • Sergio Wittlin
  • Jonathan L. Vennerstrom

Best Publications

  • Strategies to Address Low Drug Solubility in Discovery and Development

    Hywel David Williams;Natalie Trevaskis;Susan Ann Charman;Ravi Shanker

  • Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

    Paul A. Adlard;Robert A. Cherny;Robert A. Cherny;David I. Finkelstein;David I. Finkelstein;Elisabeth Gautier

  • Identification of an antimalarial synthetic trioxolane drug development candidate.

    Jonathan L Vennerstrom;Sarah Arbe-Barnes;Reto Brun;Susan A Charman

  • Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.

    Susan A. Charman;William N. Charman;Mark C. Rogge;Terry D. Wilson

  • A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Beatriz Baragaña;Irene Hallyburton;Marcus C. S. Lee;Marcus C. S. Lee;Neil R. Norcross

  • Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

    Susan A. Charman;Sarah Arbe-Barnes;Ian C. Bathurst;Reto Brun

  • Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

    Jose M. Coteron;María Marco;Jorge Esquivias;Xiaoyi Deng

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    Margaret A. Phillips;Julie Lotharius;Kennan Marsh;John White

  • Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

    Jonathan B. Baell;Jonathan B. Baell;David Leaver;Stefan J. Hermans;Gemma L. Kelly;Gemma L. Kelly

  • Lymphatic Transport of Proteins After Subcutaneous Administration

    Christopher J.H. Porter;Susan A. Charman

  • Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

    Yongyuth Yuthavong;Bongkoch Tarnchompoo;Tirayut Vilaivan;Penchit Chitnumsub

  • Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

    Aaron Nilsen;Alexis N. LaCrue;Karen L. White;Isaac P. Forquer

  • (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

    María Belén Jiménez-Díaz;Daniel Ebert;Yandira Salinas;Anupam Pradhan

  • Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

    Ramesh Gujjar;Alka Marwaha;Farah El Mazouni;John White

  • Subcutaneous drug delivery and the role of the lymphatics.

    Danielle N McLennan;Christopher John H Porter;Susan A Charman

  • Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

    Tanya Paquet;Claire Le Manach;Diego González Cabrera;Yassir Younis

  • Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

    Ramesh Gujjar;Farah El Mazouni;Karen L. White;John White

  • Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

    Bernard L. Flynn;Gurmit S. Gill;Damian W. Grobelny;Jason H. Chaplin

  • Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

    J. Stone Doggett;Aaron Nilsen;Isaac Forquer;Keith W. Wegmann

  • A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

    M. A. Phillips;J. Lotharius;K. Marsh;J. White

Frequent Co-Authors

Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Jonathan L. Vennerstrom
Jonathan L. Vennerstrom University of Nebraska Medical Center
Vicky M. Avery
Vicky M. Avery Griffith University
Christopher J.H. Porter
Christopher J.H. Porter Monash University
Darren J. Creek
Darren J. Creek Monash University
Jonathan B. Baell
Jonathan B. Baell Monash University
Margaret A. Phillips
Margaret A. Phillips The University of Texas Southwestern Medical Center
Ric N. Price
Ric N. Price Charles Darwin University
David A. Fidock
David A. Fidock Columbia University
Kelly Chibale
Kelly Chibale University of Cape Town

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