Paul M. O'Neill

Overview

Best Publications

• Artemisinins target the SERCA of Plasmodium falciparum

  U. Eckstein-Ludwig;R. J. Webb;I. D. A. van Goethem;J. M. East

  1352
  Citations

• Metabolism of fluorine-containing drugs.

  B K Park;N R Kitteringham;P M O'Neill

  815
  Citations

• The molecular mechanism of action of artemisinin - the debate continues.

  Paul M. O’Neill;Victoria E. Barton;Stephen A. Ward

  775
  Citations

• A medicinal chemistry perspective on artemisinin and related endoperoxides.

  Paul M. O'neill;Gary H. Posner

  677
  Citations

• 4-Aminoquinolines—Past, present, and future; A chemical perspective

  P M O'Neill;P G Bray;S R Hawley;S A Ward

  392
  Citations

• Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.

  Bradley J. Stevenson;Jaclyn Bibby;Patricia Pignatelli;Sant Muangnoicharoen

  310
  Citations

• Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7

  Hanafy M. Ismail;Victoria Barton;Matthew Phanchana;Sitthivut Charoensutthivarakul

  298
  Citations

• Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

  Amy E. Mercer;James L. Maggs;Xiao-Ming Sun;Gerald M. Cohen

  266
  Citations

• Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro

  Shaun R. Hawley;Patrick G. Bray;Mathirut Mungthin;Jill D. Atkinson

  236
  Citations

• Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.

  Kangsa Amporndanai;Xiaoli Meng;Weijuan Shang;Zhenmig Jin

  231
  Citations

• Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.

  Gary H Posner;Paul M O'Neill

  221
  Citations

• Antimalarial pharmacology and therapeutics of atovaquone

  Gemma L. Nixon;Darren M. Moss;Alison E. Shone;David G. Lalloo

  219
  Citations

• Seeing the same thing differently

  Peter Yeates;Paul O’Neill;Karen Mann;Kevin Eva

  215
  Citations

• The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

  Amy E. Mercer;Ian M. Copple;James L. Maggs;Paul M. O'Neill

  200
  Citations

• Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

  Giancarlo A. Biagini;Nicholas Fisher;Alison E. Shone;Murad A. Mubaraki

  199
  Citations

• Quinolines and Artemisinin: Chemistry, Biology and History

  Patrick Bray;Stephen Ward;P. M O'Neill

  196
  Citations

• Evaluations of situational judgement tests to assess non-academic attributes in selection.

  Fiona Patterson;Victoria Ashworth;Lara Zibarras;Philippa Coan

  193
  Citations

• Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials

  Paul M O'Neill;Amira Mukhtar;Paul A Stocks;Laura E Randle

  188
  Citations

• Novel Short Chain Chloroquine Analogues Retain Activity Against Chloroquine Resistant K1 Plasmodium falciparum

  Paul A Stocks;Kaylene J Raynes;Patrick G Bray;B Kevin Park

  175
  Citations

• Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications

  P. F. O'Neill;A. Ben Azouz;M. Vázquez;J. Liu

  169
  Citations

• Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.

  Giancarlo A. Biagini;Parnpen Viriyavejakul;Paul M. O'Neill;Patrick G. Bray

  164
  Citations

• Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

  Paul M O'Neill;Richard K Amewu;Gemma L Nixon;Fatima Bousejra ElGarah

  163
  Citations