World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
64
Citations
12905
World Ranking
8138
National Ranking
11

Research.com Recognitions

  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa
  • Fellow of the Royal Society of South Africa

Overview

Kelly Chibale is affiliated with the University of Cape Town in South Africa and conducts research primarily in the field of medicine. Their work focuses extensively on infectious diseases and public health, with particular emphasis on malaria research and control as well as computational drug discovery methods.

The scientist has published numerous papers covering a range of topics related to infectious diseases, including malaria, leishmaniasis, tuberculosis, and HIV/AIDS drug development. Their research also extends to cancer therapeutics and mosquito-borne diseases. Key areas of study include:

  • Malaria Research and Control
  • Research on Leishmaniasis Studies
  • Computational Drug Discovery Methods
  • Tuberculosis Research and Epidemiology
  • HIV/AIDS drug development and treatment
  • Cancer therapeutics and mechanisms
  • Mosquito-borne diseases and control

Chibale's subfields of study highlight a multidisciplinary approach incorporating molecular biology, organic chemistry, computational theory and mathematics, and public health. The most frequent publication venues for their work include:

  • ACS Infectious Diseases
  • Journal of Medicinal Chemistry
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Trends in Parasitology

Frequent coauthors collaborating with Kelly Chibale include Janette Reader, Mariëtte van der Watt, Lyn-Marié Birkholtz, Mathew Njoroge, and Dale Taylor.

Recent notable papers authored or coauthored by Kelly Chibale include:

  • Antiviral drug discovery: preparing for the next pandemic (2021, Chemical Society Reviews)
  • MalDA, Accelerating Malaria Drug Discovery (2021, Trends in Parasitology)
  • Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box (2021, Nature Communications)
  • Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity (2020, Cell chemical biology)
  • Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities (2021, ACS Infectious Diseases)

Kelly Chibale has received recognition in the form of an appointment as Fellow of the Royal Society of South Africa.

Best Publications

  • Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

    Eric M. Guantai;Kanyile Ncokazi;Timothy J. Egan;Jiri Gut

  • Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

    Kelly Chibale;Mark Visser;Donelly van Schalkwyk;Peter J Smith

  • Antiviral drug discovery: preparing for the next pandemic.

    Catherine S Adamson;Kelly Chibale;Rebecca J M Goss;Marcel Jaspars

  • Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

    Renate H. Hans;Eric M. Guantai;Carmen Lategan;Peter J. Smith

  • Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives

    Idan Chiyanzu;Cailean Clarkson;Peter J. Smith;Julie Lehman

  • Strategies to Combat Multi-Drug Resistance in Tuberculosis.

    Vinayak Singh;Vinayak Singh;Kelly Chibale;Kelly Chibale

  • The state of the art in anti-malarial drug discovery and development.

    Jeremy N. Burrows;Kelly Chibale;Timothy N.C. Wells

  • Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.

    Idan Chiyanzu;Elizabeth Hansell;Jiri Gut;Philip J. Rosenthal

  • Antimalarial drug discovery: progress and approaches

    Unknown

  • 3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

    Yassir Younis;Frederic Douelle;Tzu-Shean Feng;Diego Gonzalez Cabrera

  • Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery.

    Moses Hohman;Kellan Gregory;Kelly Chibale;Peter J. Smith

  • Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

    Kelly Chibale;Hayley Haupt;Howard Kendrick;Vanessa Yardley

  • Synthesis and antiplasmodial activity in vitro of new ferrocene–chloroquine analogues

    Paul Beagley;Margaret A. L. Blackie;Kelly Chibale;Cailean Clarkson

  • Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis.

    Mathew Njoroge;Nicholas M. Njuguna;Peggoty Mutai;Dennis S. B. Ongarora

  • Antimalarial Pyrido[1,2-a]benzimidazoles

    Albert J. Ndakala;Richard K. Gessner;Patricia W. Gitari;Natasha October

  • UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

    Christel Brunschwig;Nina Lawrence;Dale Taylor;Efrem Abay

  • Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies.

    Kamaljit Singh;Hardeep Kaur;Peter Smith;Carmen de Kock

  • Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity

    Prinessa Chellan;Shereen Nasser;Livia Vivas;Kelly Chibale

  • Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV

    K.C. Nicolaou;K.C. Nicolaou;John I. Trujillo;John I. Trujillo;Kelly Chibale;Kelly Chibale

  • Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

    Eric M. Guantai;Kanyile Ncokazi;Timothy J. Egan;Jiri Gut

  • The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(II)-arene complexes.

    Muneebah Adams;Yiqun Li;Heena Khot;Carmen De Kock

  • New amine and urea analogs of ferrochloroquine: synthesis, antimalarial activity in vitro and electrochemical studies

    Kelly Chibale;John R Moss;Margaret Blackie;Donelly van Schalkwyk

Frequent Co-Authors

Peter Smith
Peter Smith University of Aberdeen
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Philip J. Rosenthal
Philip J. Rosenthal University of California, San Francisco
Jiri Gut
Jiri Gut University of California, San Francisco
Timothy J. Egan
Timothy J. Egan University of Cape Town
Susan A. Charman
Susan A. Charman Monash University
Vanessa Yardley
Vanessa Yardley London School of Hygiene & Tropical Medicine
Norbert De Kimpe
Norbert De Kimpe Ghent University
K. C. Nicolaou
K. C. Nicolaou Rice University
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego

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