What is he best known for?
The fields of study he is best known for:
- Enzyme
- Organic chemistry
- Biochemistry
Kelly Chibale spends much of his time researching Stereochemistry, Plasmodium falciparum, Pharmacology, In vitro and Malaria.
His Stereochemistry research incorporates elements of Combinatorial chemistry, Quinoline, Chemical synthesis and Antimycobacterial.
His Plasmodium falciparum study combines topics from a wide range of disciplines, such as Biochemistry, Structure–activity relationship, Cysteine protease and Cytotoxicity.
The Pharmacology study combines topics in areas such as Chloroquine, Artemisinin, In vivo and Plasmodium berghei.
His studies deal with areas such as Chalcone and Strain as well as In vitro.
His Malaria research incorporates themes from Environmental health, Virology, African trypanosomiasis, Drug resistance and Drug discovery.
His most cited work include:
- Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. (205 citations)
- Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds (135 citations)
- Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents (132 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Plasmodium falciparum, Stereochemistry, Pharmacology, In vitro and Biochemistry.
Kelly Chibale works mostly in the field of Plasmodium falciparum, limiting it down to topics relating to Structure–activity relationship and, in certain cases, Parasite hosting, as a part of the same area of interest.
His Stereochemistry research includes themes of Antimycobacterial, Quinoline and Chemical synthesis.
His study in Pharmacology is interdisciplinary in nature, drawing from both Metabolite, Hemozoin, In vivo and Plasmodium berghei.
His studies in In vitro integrate themes in fields like Mode of action and Strain.
His study looks at the relationship between Biochemistry and fields such as Mycobacterium tuberculosis, as well as how they intersect with chemical problems.
He most often published in these fields:
- Plasmodium falciparum (47.09%)
- Stereochemistry (37.22%)
- Pharmacology (34.68%)
What were the highlights of his more recent work (between 2017-2021)?
- Plasmodium falciparum (47.09%)
- Malaria (20.25%)
- In vivo (17.72%)
In recent papers he was focusing on the following fields of study:
Kelly Chibale mainly investigates Plasmodium falciparum, Malaria, In vivo, Pharmacology and Drug discovery.
The various areas that Kelly Chibale examines in his Plasmodium falciparum study include Mode of action, Chloroquine, Benzimidazole and Cytotoxicity.
His research ties Stereochemistry and Cytotoxicity together.
His Malaria research is multidisciplinary, incorporating perspectives in Humanized mouse and Virology.
His research in In vivo intersects with topics in Multiple drug resistance, In vitro, ADME, hERG and Kinase.
Kelly Chibale combines subjects such as Intensive care medicine, Druggability, Artemisinin, Computational biology and Drug with his study of Drug discovery.
Between 2017 and 2021, his most popular works were:
- UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. (76 citations)
- Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl. (30 citations)
- Recent updates in the discovery and development of novel antimalarial drug candidates. (30 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Catalysis
His primary scientific interests are in Plasmodium falciparum, Drug discovery, Malaria, Pharmacology and Microsome.
The study incorporates disciplines such as Combinatorial chemistry, Chloroquine, Stereochemistry and Quinoline in addition to Plasmodium falciparum.
Borrowing concepts from Bioorganometallic chemistry, Kelly Chibale weaves in ideas under Stereochemistry.
His research integrates issues of Humanized mouse and Drug in his study of Malaria.
He interconnects Mediator, Kinase and In vivo in the investigation of issues within Pharmacology.
His Microsome study integrates concerns from other disciplines, such as Mechanism of action, Structure–activity relationship and Mycobacterium tuberculosis.
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