World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
103
Citations
39147
World Ranking
349
National Ranking
160

Research.com Recognitions

  • 2016 - Fellow of the American Society of Tropical Medicine and Hygiene (ASTMH)

Overview

David A. Fidock is affiliated with Columbia University in the United States and has contributed extensively to the field of medicine, focusing primarily on infectious diseases with a particular emphasis on malaria research and control. Their work bridges multiple subfields, including public health, environmental and occupational health, computational theory and mathematics, molecular biology, infectious diseases, and epidemiology.

The scientist's main research topics include:

  • Malaria Research and Control
  • Computational Drug Discovery Methods
  • Mosquito-borne diseases and control
  • HIV/AIDS drug development and treatment
  • Research on Leishmaniasis Studies
  • Trypanosoma species research and implications
  • Drug Transport and Resistance Mechanisms

Frequent coauthors in David A. Fidock's publications include:

  • Tomas Yeo
  • Sachel Mok
  • Lee M
  • Elizabeth A. Winzeler
  • Francisco-Javier Gamo

Their research has appeared predominantly in reputable scientific journals, with frequent publications in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Nature Communications
  • Cell chemical biology
  • PLoS Pathogens

Notable recent papers authored or coauthored include:

  • Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda (2020, Nature Medicine)
  • Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria (2020, Annual Review of Microbiology)
  • Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance (2020, eLife)
  • Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea (2023, New England Journal of Medicine)
  • Antimalarial drug discovery: progress and approaches (2023, Nature Reviews Drug Discovery)

David A. Fidock's contributions have been recognized by their election as a Fellow of the American Society of Tropical Medicine and Hygiene (ASTMH) in 2016.

Best Publications

  • Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

    David A. Fidock;Takashi Nomura;Angela K. Talley;Roland A. Cooper

  • Spiroindolones, a Potent Compound Class for the Treatment of Malaria

    Matthias Rottmann;Matthias Rottmann;Case McNamara;Bryan K.S. Yeung;Marcus C.S. Lee

  • A molecular marker for chloroquine-resistant falciparum malaria.

    Abdoulaye Djimdé;Ogobara K. Doumbo;Joseph F. Cortese;Kassoum Kayentao

  • Antimalarial drug discovery: efficacy models for compound screening

    David A. Fidock;Philip J. Rosenthal;Simon L. Croft;Reto Brun

  • Malaria: progress, perils, and prospects for eradication

    Brian M. Greenwood;David A. Fidock;Dennis E. Kyle;Stefan H.I. Kappe

  • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

    Amar Bir Singh Sidhu;Dominik Verdier-Pinard;David A. Fidock

  • K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

    Judith Straimer;Nina F. Gnädig;Benoit Witkowski;Chanaki Amaratunga

  • Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

    Aline Uwimana;Eric Legrand;Barbara H. Stokes;Jean-Louis Mangala Ndikumana

  • Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

    Richard T. Eastman;David A. Fidock

  • Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

    David A. Fidock;Thomas E. Wellems

  • A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms

    Didier Ménard;Nimol Khim;Johann Beghain;Ayola A. Adegnika;Ayola A. Adegnika

  • Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.

    Benjamin Blasco;Didier Leroy;David A Fidock

  • Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.

    Amar Bir Singh Sidhu;Anne-Catrin Uhlemann;Stephanie G. Valderramos;Juan-Carlos Valderramos

  • A novel multiple-stage antimalarial agent that inhibits protein synthesis

    Beatriz Baragaña;Irene Hallyburton;Marcus C. S. Lee;Marcus C. S. Lee;Neil R. Norcross

  • pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.

    Amar Bir Singh Sidhu;Stephanie Gaw Valderramos;David A. Fidock

  • A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

    Benoit Witkowski;Valentine Duru;Nimol Khim;Leila S Ross

  • Targeting Plasmodium PI(4)K to eliminate malaria

    Case W McNamara;Marcus Cs Lee;Chek Shik Lim;Siau Hoi Lim

  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

    Wesley C. Van Voorhis;John H. Adams;Roberto Adelfio;Roberto Adelfio;Vida Ahyong

  • TARGETING THE CELL STRESS RESPONSE OF PLASMODIUM FALCIPARUM TO OVERCOME ARTEMISININ RESISTANCE

    Con Dogovski;Stanley C. Xie;Gaetan Burgio;Jess Bridgford

  • Artemisinin Action and Resistance in Plasmodium falciparum.

    Leann Tilley;Judith Straimer;Nina F. Gnädig;Stuart A. Ralph

  • Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

    Stephan Meister;David M. Plouffe;Kelli L. Kuhen;Ghislain M. C. Bonamy

Frequent Co-Authors

Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Dyann F. Wirth
Dyann F. Wirth Harvard University
François Nosten
François Nosten MORU Mahidol Oxford Tropical Medicine Research Unit
Manuel Llinás
Manuel Llinás Pennsylvania State University
Thomas E. Wellems
Thomas E. Wellems National Institutes of Health
Vicky M. Avery
Vicky M. Avery Griffith University
Xin-zhuan Su
Xin-zhuan Su National Institutes of Health
Susan A. Charman
Susan A. Charman Monash University
Dennis E. Kyle
Dennis E. Kyle University of Georgia

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