Sergio Wittlin

Overview

Best Publications

• Identification of an antimalarial synthetic trioxolane drug development candidate.

  Jonathan L Vennerstrom;Sarah Arbe-Barnes;Reto Brun;Susan A Charman

  773
  Citations

• A novel multiple-stage antimalarial agent that inhibits protein synthesis

  Beatriz Baragaña;Irene Hallyburton;Marcus C. S. Lee;Marcus C. S. Lee;Neil R. Norcross

  500
  Citations

• The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.

  Michael J Delves;David Plouffe;Christian Scheurer;Christian Scheurer;Stephan Meister

  470
  Citations

• Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

  Susan A. Charman;Sarah Arbe-Barnes;Ian C. Bathurst;Reto Brun

  455
  Citations

• A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

  Margaret A. Phillips;Julie Lotharius;Kennan Marsh;John White

  363
  Citations

• Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

  Tanya Paquet;Claire Le Manach;Diego González Cabrera;Yassir Younis

  246
  Citations

• Differential hypermethylation of SOCS genes in ovarian and breast carcinomas

  Kate D Sutherland;Geoffrey J Lindeman;David Y H Choong;Sergio Wittlin

  212
  Citations

• Discovery of dual function acridones as a new antimalarial chemotype.

  Jane X. Kelly;Martin J. Smilkstein;Reto Brun;Sergio Wittlin

  207
  Citations

• Socs2 and elf5 mediate prolactin-induced mammary gland development.

  Jessica Harris;Prudence M. Stanford;Kate Sutherland;Samantha R. Oakes

  197
  Citations

• In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

  Christopher Snyder;Jacques Chollet;Josefina Santo-Tomas;Christian Scheurer

  165
  Citations

• Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

  Paul M O'Neill;Richard K Amewu;Gemma L Nixon;Fatima Bousejra ElGarah

  163
  Citations

• 3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

  Yassir Younis;Frederic Douelle;Tzu-Shean Feng;Diego Gonzalez Cabrera

  159
  Citations

• First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

  Joerg J. Moehrle;Stephan Duparc;Christoph Siethoff;Paul L. M. van Giersbergen

  157
  Citations

• Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

  Yuxiang Dong;Jacques Chollet;Hugues Matile;Susan A Charman

  156
  Citations

• Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

  Michael L. Booker;Cecilia M. Bastos;Martin L. Kramer;Robert H. Barker

  145
  Citations

• SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.

  Geoffrey J. Lindeman;Sergio Wittlin;Hania Lada;Matthew J. Naylor

  139
  Citations

• UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

  Christel Brunschwig;Nina Lawrence;Dale Taylor;Efrem Abay

  128
  Citations

• The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

  Yuxiang Dong;Sergio Wittlin;Kamaraj Sriraghavan;Jacques Chollet

  124
  Citations

• Antiparasitic agents: new drugs on the horizon.

  Pascal Mäser;Sergio Wittlin;Sergio Wittlin;Matthias Rottmann;Matthias Rottmann;Tanja Wenzler;Tanja Wenzler

  115
  Citations

• A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

  M. A. Phillips;J. Lotharius;K. Marsh;J. White

  17
  Citations