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Medicine

D-Index
76
Citations
19365
World Ranking
18852
National Ranking
9395

Overview

Henry D. Appelman is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on medicine, with specific work in surgery, oncology, gastroenterology, pulmonary and respiratory medicine, and molecular biology.

Appelman's recent publications include a range of papers addressing topics in cancer research, immunotherapy, and gastroenterology. Notable works are:

  • Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice, 2020, Journal of Clinical Investigation
  • Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy, 2022, ACS Nano
  • Evidence of Duodenal Epithelial Barrier Impairment and Increased Pyroptosis in Patients With Functional Dyspepsia on Confocal Laser Endomicroscopy and "Ex Vivo" Mucosa Analysis, 2020, The American Journal of Gastroenterology
  • Multiplexed endoscopic imaging of Barrett's neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study, 2020, Gut
  • Detection of Barrett's neoplasia with a near-infrared fluorescent heterodimeric peptide, 2022, Endoscopy

The frequent coauthors collaborating with Appelman include:

  • D. Kim Turgeon
  • Thomas D. Wang
  • Jing Chen
  • Padma Kadiyala
  • Stephen V. Carney

The primary venues where Appelman publishes are diverse and include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gastroenterology
  • Clinical and Translational Gastroenterology
  • Journal of Clinical Investigation
  • ACS Nano

The main topics of Appelman's research focus on several areas within gastrointestinal and cancer studies:

  • Esophageal Cancer Research and Treatment
  • Gastric Cancer Management and Outcomes
  • Gastrointestinal Tumor Research and Treatment
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • Helicobacter pylori-related gastroenterology studies
  • Eosinophilic Esophagitis

Appelman's work spans multiple complex fields with an emphasis on research that intersects oncology, immunotherapy, and gastrointestinal diseases. The scope of studies reflects a focus on both molecular mechanisms and clinical applications, bridging basic science and medical treatment approaches.

Best Publications

  • Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications

    Robert H. Riddell;Harvey Goldman;David F. Ransohoff;Henry D. Appelman

  • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

    Emina H. Huang;Mark J. Hynes;Tao Zhang;Tao Zhang;Christophe Ginestier

  • Achalasia. A morphologic study of 42 resected specimens.

    John R. Goldblum;Richard I. Whyte;Mark B. Orringer;Henry D. Appelman

  • Arteriovenous Malformations of the Gastrointestinal Tract

    John D. Moore;Norman W. Thompson;Henry D. Appelman;Dennis Foley

  • Gastric epithelioid leiomyoma and leiomyosarcoma(leiomyoblastoma)

    Henry D. Appelman;Elson B. Helwig

  • Hepatic fat fraction: MR imaging for quantitative measurement and display--early experience.

    Hero K. Hussain;Thomas L. Chenevert;Frank J. Londy;Vikas Gulani

  • Histopathology differentiates acute self-limited colitis from ulcerative colitis.

    Timothy T. Nostrant;Neelam B. Kumar;Henry D. Appelman

  • Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer.

    Joseph E. Carpentino;Mark J. Hynes;Henry D. Appelman;Tong Zheng

  • Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon

    Takao Hinoi;Masachika Tani;Masachika Tani;Peter C. Lucas;Karel Caca

  • Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and in the gastric cardia

    Randy J. Kalish;Paul E. Clancy;Mark B. Orringer;Henry D. Appelman

  • Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression

    C. Richard Boland;Juichi Sato;Juichi Sato;Henry D. Appelman;Robert S. Bresalier

  • Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time.

    Celina G. Kleer;Henry D. Appelman

  • ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

    Carl Koschmann;Anda-Alexandra Calinescu;Felipe J. Nunez;Alan Mackay

  • Endoscopic and histological patchiness in treated ulcerative colitis.

    Byungki Kim;Jeffrey L. Barnett;Celina G. Kleer;Henry D. Appelman

  • Extracellular Calcium and Calcium Sensing Receptor Function in Human Colon Carcinomas: Promotion of E-Cadherin Expression and Suppression of β-Catenin/TCF Activation

    Subhas Chakrabarty;Venugopal Radjendirane;Henry Appelman;James Varani

  • Regression of hepatic steatosis in morbidly obese persons after gastric bypass

    Eugene M. Silverman;James A. Sapala;Henry D. Appelman

  • Prediction of Barrett's esophagus among men

    Joel H Rubenstein;Hal Morgenstern;Henry Appelman;James Scheiman

  • Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial.

    Milton G. Mutchnick;Henry D. Appelman;H. T. Chung;Emma Aragona

  • Lymphocytic gastritis in patients with celiac sprue or spruelike intestinal disease.

    Robert Wolber;Robert Wolber;David Owen;David Owen;Lisa DelBuono;Lisa DelBuono;Henry Appelman;Henry Appelman

  • The histopathologic spectrum of acute self-limited colitis (acute infectious-type colitis).

    Neelam B. Kumar;Timothy T. Nostrant;Henry D. Appelman

Frequent Co-Authors

David G. Beer
David G. Beer University of Michigan–Ann Arbor
Rork Kuick
Rork Kuick University of Michigan–Ann Arbor
John M. Inadomi
John M. Inadomi University of Utah
Joel K. Greenson
Joel K. Greenson University of Michigan–Ann Arbor
Hal Morgenstern
Hal Morgenstern University of Michigan–Ann Arbor
Pedro R. Lowenstein
Pedro R. Lowenstein University of Michigan–Ann Arbor
Maria G. Castro
Maria G. Castro University of Michigan–Ann Arbor
Mark B. Orringer
Mark B. Orringer University of Michigan–Ann Arbor
Eun-Young Choi
Eun-Young Choi Vanderbilt University
William D. Chey
William D. Chey University of Michigan–Ann Arbor

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