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Biology and Biochemistry

D-Index
79
Citations
22405
World Ranking
4317
National Ranking
2102

Medicine

D-Index
80
Citations
22642
World Ranking
17147
National Ranking
8592

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Pedro R. Lowenstein is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with specific contributions in the subfields of genetics, molecular biology, immunology, oncology, and cancer research.

The scientist has been involved extensively in topics including glioma diagnosis and treatment, virus-based gene therapy research, immune cells in cancer, immunotherapy and immune responses, epigenetics and DNA methylation, CAR-T cell therapy research, and cell image analysis techniques.

Frequently published venues for their research include Neuro-Oncology, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Nature Communications, and Frontiers in Oncology.

Some of their recent papers are:

  • Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy, 2020, Nature Communications
  • Purine metabolism regulates DNA repair and therapy resistance in glioblastoma, 2020, Nature Communications
  • Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging, 2023, Nature Medicine
  • Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice, 2020, Journal of Clinical Investigation
  • Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy, 2022, ACS Nano

Collaborators who have frequently co-authored works with this scientist include María G. Castro, Syed Mohd Faisal, Andrea Comba, María L. Varela, and Padma Kadiyala.

Pedro R. Lowenstein's career achievements include recognition as a Fellow of the American Association for the Advancement of Science (AAAS) awarded in 2018 and membership in the Association of American Physicians.

Best Publications

  • The Collaborative Cross, a community resource for the genetic analysis of complex traits

    Gary A. Churchill;David C. Airey;Hooman Allayee;Joe M. Angel

  • Consensus guidelines for the detection of immunogenic cell death

    Oliver Kepp;Laura Senovilla;Ilio Vitale;Erika Vacchelli

  • Nicotinic acetylcholine binding sites in Alzheimer's disease.

    Peter J. Whitehouse;Andrea M. Martino;Piero G. Antuono;Pedro R. Lowenstein

  • Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.

    R. A. Dewey;G. Morrissey;C. M. Cowsill;D. Stone

  • Platelets Mediate Cytotoxic T Lymphocyte-Induced Liver Damage.

    Matteo Iannacone;Giovanni Sitia;Masanori Isogawa;Patrizia Marchese

  • Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression

    Marianela Candolfi;Marianela Candolfi;James F. Curtin;James F. Curtin;W. Stephen Nichols;A. K.M.G. Muhammad

  • HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

    James F Curtin;James F Curtin;Naiyou Liu;Naiyou Liu;Marianela Candolfi;Marianela Candolfi;Weidong Xiong;Weidong Xiong

  • Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.

    Clare E. Thomas;Gudrun Schiedner;Stefan Kochanek;Maria G. Castro

  • Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges

    Shyam Goverdhana;Mariana Puntel;Weidong Xiong;Jeffrey M Zirger

  • Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

    Saleta Sierra;Mercedes Dávila;Pedro R. Lowenstein;Esteban Domingo

  • Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

    Jason V. Gregory;Padma Kadiyala;Robert Doherty;Melissa Cadena

  • Progress in gene therapy for neurological disorders

    Michele Simonato;Jean Bennett;Nicholas M. Boulis;Maria G. Castro

  • Current and future strategies for the treatment of malignant brain tumors

    M.G Castro;R Cowen;I.K Williamson;I.K Williamson;A David

  • ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

    Carl Koschmann;Anda-Alexandra Calinescu;Felipe J. Nunez;Alan Mackay

  • Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.

    Adrian E. Morelli;Adriana T. Larregina;Joseph Smith-Arica;Ricardo A. Dewey

  • Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions

    Pedro R. Lowenstein;Ronald J. Mandel;Wei Dong Xiong;Kurt Kroeger

  • Suppression of viral infectivity through lethal defection

    Ana Grande-Pérez;Ester Lázaro;Pedro Lowenstein;Esteban Domingo

  • IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

    Felipe J. Núñez;Flor M. Mendez;Padma Kadiyala;Mahmoud S. Alghamri

  • Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

    Nonia Pariente;Saleta Sierra;Pedro R. Lowenstein;Esteban Domingo

  • Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain.

    Clare E. Thomas;Darren Birkett;Ijeoma Anozie;Maria G. Castro

Frequent Co-Authors

Maria G. Castro
Maria G. Castro University of Michigan–Ann Arbor
David Altshuler
David Altshuler Harvard University
David Klatzmann
David Klatzmann Sorbonne University
Chris M. Preston
Chris M. Preston University of Glasgow
Alan K. Meeker
Alan K. Meeker Johns Hopkins University School of Medicine
Daniel P. Cardinali
Daniel P. Cardinali Pontifical Catholic University of Argentina
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
James J. Moon
James J. Moon University of Michigan–Ann Arbor
Joseph T. Coyle
Joseph T. Coyle Harvard University
Henry D. Appelman
Henry D. Appelman University of Michigan–Ann Arbor

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