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2026

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Best Scientists

D-Index
184
Citations
143028
World Ranking
525
National Ranking
339

Neuroscience

D-Index
192
Citations
150265
World Ranking
38
National Ranking
25

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2021 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 2019 - Warren Alpert Foundation Prize For the development of optogenetics as a way to control the activity of specific circuits in the nervous system, to determine their function and ultimately to control them to treat neurological and psychiatric disorders.
  • 2019 - Member of the National Academy of Engineering For molecular and optical tools for discovery and control of neuronal signals behind animal behavior in health and disease.
  • 2018 - Fellow, National Academy of Inventors
  • 2018 - Canada Gairdner International Award
  • 2017 - Fellow of the Indian National Academy of Engineering (INAE)
  • 2016 - Breakthrough Prize in Life Sciences for the development and implementation of optogenetics – the programming of neurons to express light-activated ion channels and pumps, so that their electrical activity can be controlled by light.
  • 2015 - BBVA Foundation Frontiers of Knowledge Award
  • 2015 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2015 - Lurie Prize in Biomedical Sciences, Foundation for the National Institutes of Health
  • 2014 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 2014 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Neurosciences
  • 2013 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for pioneering the technology called optogenetics in which insertion of a single bacterial protein into a neuron allows exquisite control of the neuron with light.
  • 2013 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2013 - The Brain Prize, Lundbeck Foundation For their invention and refinement of optogenetics. This revolutionary technique allows genetically specified populations of neurons to be turned on or off with light, offering not only the ability to elucidate the characteristics of normal and abnormal neural circuitry but also new approaches to treatment of brain disorders
  • 2012 - Member of the National Academy of Sciences
  • 2011 - Perl-UNC Prize, University of North Carolina at Chapel Hill Development and Application of Optogenetics for Studying Neural Circuit Functions.
  • 2011 - W. Alden Spencer Award, College of Physicians and Surgeons
  • 2010 - Member of the National Academy of Medicine (NAM)
  • 2009 - Golden Brain Award, Minerva Foundation
  • 2005 - National Institutes of Health Director's Pioneer Award

Overview

Karl Deisseroth is affiliated with Stanford University in the United States. Their research spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a particular focus on Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology, Biophysics, and Biomedical Engineering.

The main research topics covered in their work include Photoreceptor and optogenetics research, Neural dynamics and brain function, Neuroscience and Neural Engineering, Neuroscience and Neuropharmacology Research, Receptor Mechanisms and Signaling, Memory and Neural Mechanisms, and Neurotransmitter Receptor Influence on Behavior.

Several recent papers highlight Karl Deisseroth's contributions across multiple high-profile journals:

  • Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics, 2022, Science
  • Maturation and circuit integration of transplanted human cortical organoids, 2022, Nature
  • Deep posteromedial cortical rhythm in dissociation, 2020, Nature
  • Cardiogenic control of affective behavioural state, 2023, Nature
  • Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set, 2020, Science

Frequent collaborators include Charu Ramakrishnan, Lief E. Fenno, Yoon Seok Kim, and Zhenan Bao.

Karl Deisseroth has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell, Neuron, UNC Libraries, and Science.

In addition to journal publications, Karl Deisseroth has authored books, including "Les fils tressés de nos sentiments," published by Dunod in 2022.

Their work has been recognized through numerous awards and honors, including:

  • Albert Lasker Award for Basic Medical Research, 2021
  • Member of the National Academy of Engineering, 2019, for molecular and optical tools for discovery and control of neuronal signals behind animal behavior in health and disease
  • Warren Alpert Foundation Prize, 2019, for development of optogenetics as a tool to control nervous system circuits
  • Canada Gairdner International Award, 2018
  • Fellow, National Academy of Inventors, 2018
  • Fellow of the Indian National Academy of Engineering, 2017
  • Breakthrough Prize in Life Sciences, 2016, for development and implementation of optogenetics
  • BBVA Foundation Frontiers of Knowledge Award, 2015
  • Lurie Prize in Biomedical Sciences, 2015
  • Albany Medical Center Prize in Medicine and Biomedical Research, 2015
  • Keio Medical Science Prize, 2014
  • German National Academy of Sciences Leopoldina, 2014, Neurosciences
  • Richard Lounsbery Award, 2013, for pioneering optogenetics technology
  • The Brain Prize, Lundbeck Foundation, 2013, for invention and refinement of optogenetics
  • Robert J. and Claire Pasarow Foundation Medical Research Award, 2013
  • Member of the National Academy of Sciences, 2012
  • Perl-UNC Prize, 2011, for development and application of optogenetics to study neural circuits
  • W. Alden Spencer Award, 2011
  • Member of the National Academy of Medicine, 2010
  • Golden Brain Award, Minerva Foundation, 2009
  • National Institutes of Health Director's Pioneer Award, 2005

Best Publications

  • Millisecond-timescale, genetically targeted optical control of neural activity.

    Edward S Boyden;Feng Zhang;Ernst Bamberg;Georg Nagel

  • Driving fast-spiking cells induces gamma rhythm and controls sensory responses

    Jessica A. Cardin;Marie Carlén;Marie Carlén;Konstantinos Meletis;Konstantinos Meletis;Ulf Knoblich

  • Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

    Vikaas S. Sohal;Feng Zhang;Ofer Yizhar;Karl Deisseroth

  • Neocortical excitation/inhibition balance in information processing and social dysfunction

    Ofer Yizhar;Ofer Yizhar;Lief E. Fenno;Matthias Prigge;Franziska Schneider

  • Optogenetics in neural systems.

    Ofer Yizhar;Lief E. Fenno;Thomas J. Davidson;Murtaza Mogri

  • The Development and Application of Optogenetics

    Lief Fenno;Ofer Yizhar;Karl Deisseroth

  • Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

    Alexxai V Kravitz;Benjamin S Freeze;Philip R L Parker;Kenneth Kay

  • Multimodal fast optical interrogation of neural circuitry

    Feng Zhang;Li-Ping Wang;Martin Brauner;Jana F. Liewald

  • Optogenetic stimulation of a hippocampal engram activates fear memory recall

    Xu Liu;Steve Ramirez;Petti T. Pang;Corey B. Puryear

  • Optical Deconstruction of Parkinsonian Neural Circuitry

    Viviana Gradinaru;Murtaza Mogri;Kimberly R. Thompson;Jaimie M. Henderson

  • Three-dimensional intact-tissue sequencing of single-cell transcriptional states.

    Xiao Wang;William E. Allen;Matthew A. Wright;Emily L. Sylwestrak

  • Optogenetics: 10 years of microbial opsins in neuroscience

    Karl Deisseroth

  • Neural substrates of awakening probed with optogenetic control of hypocretin neurons

    Antoine Roger Adamantidis;Feng Zhang;Alexander M Aravanis;Karl Deisseroth

  • Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

    Hsing-Chen Tsai;Feng Zhang;Antoine Roger Adamantidis;Garret D Stuber

  • Natural Neural Projection Dynamics Underlying Social Behavior

    Lisa A. Gunaydin;Logan Grosenick;Joel C. Finkelstein;Isaac V. Kauvar

  • Amygdala circuitry mediating reversible and bidirectional control of anxiety

    Kay M. Tye;Rohit Prakash;Sung-Yon Kim;Lief E. Fenno

  • Input-specific control of reward and aversion in the ventral tegmental area

    Stephan Lammel;Byung Kook Lim;Chen Ran;Kee Wui Huang

  • CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

    Haruhiko Bito;Karl Deisseroth;Richard W Tsien

  • Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

    Dipesh Chaudhury;Jessica J. Walsh;Allyson K. Friedman;Barbara Juarez

  • Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

    Viviana Gradinaru;Feng Zhang;Charu Ramakrishnan;Joanna Mattis

  • Neocortical excitation/inhibition balance in information processing and social

    Lief E. Fenno;Matthias Prigge;Franziska Schneider;Thomas J. Davidson

Frequent Co-Authors

Charu Ramakrishnan
Charu Ramakrishnan Stanford University
Viviana Gradinaru
Viviana Gradinaru California Institute of Technology
Ofer Yizhar
Ofer Yizhar Weizmann Institute of Science
Scott L. Delp
Scott L. Delp Stanford University
Ilana B. Witten
Ilana B. Witten Princeton University
Kay M. Tye
Kay M. Tye Salk Institute for Biological Studies
Peter Hegemann
Peter Hegemann Humboldt-Universität zu Berlin
Robert C. Malenka
Robert C. Malenka Stanford University
Liqun Luo
Liqun Luo Stanford University

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