His main research concerns Internal medicine, Endocrinology, Orexin, Neuropeptide and Neuroscience. His work on Ghrelin as part of general Endocrinology research is often related to Doxycycline, thus linking different fields of science. His Orexin study combines topics in areas such as Tuberomammillary nucleus, Patch clamp, Electrophysiology, Leptin and Narcolepsy.
The concepts of his Neuropeptide study are interwoven with issues in Hypothalamus and Lateral hypothalamus. He focuses mostly in the field of Neuroscience, narrowing it down to topics relating to Transgene and, in certain cases, Cell type, Mutant, Repertoire and Gene expression. His studies deal with areas such as Sleep onset and Non-rapid eye movement sleep as well as Wakefulness.
His primary areas of investigation include Neuroscience, Orexin, Endocrinology, Internal medicine and Optogenetics. Neuroscience is frequently linked to Serotonergic in his study. His research integrates issues of Cataplexy, Narcolepsy, Wakefulness and Lateral hypothalamus in his study of Orexin.
His study in Wakefulness is interdisciplinary in nature, drawing from both Arousal, Slow-wave sleep, Period, Premovement neuronal activity and Non-rapid eye movement sleep. His research in Endocrinology intersects with topics in Neuropeptide and Receptor. His Optogenetics research incorporates elements of Biophysics, Patch clamp, Transgene and Gene silencing.
Akihiro Yamanaka mainly investigates Neuroscience, Orexin, Optogenetics, Endocrinology and Internal medicine. His research investigates the connection between Neuroscience and topics such as Dorsal raphe nucleus that intersect with issues in Nociception, Rostral ventromedial medulla, Locus coeruleus and Median raphe nucleus. His biological study spans a wide range of topics, including Lateral hypothalamus, Neuron, Wakefulness and Cataplexy, Narcolepsy.
The study incorporates disciplines such as Dynorphin, Arousal, Electrophysiology and Non-rapid eye movement sleep in addition to Wakefulness. His Optogenetics research is multidisciplinary, incorporating elements of Medium spiny neuron, Biophysics, Stimulation and Serotonin. His Endocrinology study integrates concerns from other disciplines, such as Receptor and Raphe nuclei.
His scientific interests lie mostly in Neuroscience, Orexin, Optogenetics, Internal medicine and Endocrinology. His work in Neuroscience tackles topics such as Glutamate receptor which are related to areas like Inhibitory postsynaptic potential, Circadian clock, CLOCK and Period. Akihiro Yamanaka combines subjects such as Lateral hypothalamus, Calcium imaging, Wakefulness and Cataplexy, Narcolepsy with his study of Orexin.
He has researched Optogenetics in several fields, including Optical fiber, Depolarization, Dorsal raphe nucleus and Serotonin. In general Internal medicine study, his work on Oxytocin, Hypothermia and Receptor often relates to the realm of Adenosine A1 receptor, thereby connecting several areas of interest. His Endocrinology research is multidisciplinary, incorporating perspectives in Agonist and Transcription.
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Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Akihiro Yamanaka;Carsten T. Beuckmann;Jon T. Willie;Junko Hara.
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.
Takeshi Sakurai;Ruby Nagata;Akihiro Yamanaka;Hiroko Kawamura.
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
Masahisa Yamada;Tsuyoshi Miyakawa;Tsuyoshi Miyakawa;Alokesh Duttaroy;Akihiro Yamanaka.
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
Raphaëlle Winsky-Sommerer;Akihiro Yamanaka;Sabrina Diano;Erzsebet Borok.
The Journal of Neuroscience (2004)
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Koji Toshinai;Hideki Yamaguchi;Yuxiang Sun;Roy G. Smith.
Orexins activate histaminergic neurons via the orexin 2 receptor.
Akihiro Yamanaka;Natsuko Tsujino;Hisayuki Funahashi;Kazuki Honda.
Biochemical and Biophysical Research Communications (2002)
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
Shinji Muroya;Shinji Muroya;Hisayuki Funahashi;Akihiro Yamanaka;Daisuke Kohno.
European Journal of Neuroscience (2004)
Orexin-induced food intake involves neuropeptide Y pathway.
Akihiro Yamanaka;Kaiko Kunii;Tadahiro Nambu;Natsuko Tsujino.
Brain Research (2000)
Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight.
Akihiro Yamanaka;Takeshi Sakurai;Takuo Katsumoto;Masashi Yanagisawa.
Brain Research (1999)
Orexins/hypocretins regulate drinking behaviour.
Kaiko Kunii;Akihiro Yamanaka;Tadahiro Nambu;Ichiyo Matsuzaki.
Brain Research (1999)
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