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Biology and Biochemistry

D-Index
70
Citations
21814
World Ranking
6908
National Ranking
3187

Research.com Recognitions

  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Samson T. Jacob is affiliated with The Ohio State University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology, Cancer Research, Epidemiology, Hepatology, and Rheumatology as subfields of study.

The scientist's work covers several main topics, including:

  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Osteoarthritis Treatment and Mechanisms
  • Adenosine and Purinergic Signaling
  • Hepatitis B Virus Studies
  • Liver Disease Diagnosis and Treatment
  • MicroRNA in disease regulation

Frequent co-authors in Samson T. Jacob's collaborations include Kalpana Ghoshal, David Fenyö, Huban Kutay, Bo Wang, and Sarmila Majumder. Their research has been published in a variety of venues, with significant numbers appearing in Cancer Research, Cancers, Scientific Reports, Biology, and Purinergic Signalling.

Among their recent papers are:

  • Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma (2020, Cancers)
  • Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis (2020, Scientific Reports)
  • Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice (2020, Biology)
  • Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes (2021, Purinergic Signalling)
  • An integrated approach for the accurate detection of HERV-K HML-2 transcription and protein synthesis (2025, Nucleic Acids Research)

These publications reflect their involvement in studies on cancer mechanisms, osteoarthritis, liver fibrosis, adenosine receptor functions, and viral transcription detection methods.

Samson T. Jacob was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2003.

Best Publications

  • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

    Fanyin Meng;Roger Henson;Hania Wehbe-Janek;Kalpana Ghoshal

  • Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

    Dominik Paquet;Dylan Kwart;Antonia Chen;Andrew Sproul

  • MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

    Tyler E. Miller;Kalpana Ghoshal;Bhuvaneswari Ramaswamy;Satavisha Roy

  • Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

    Shu Hao Hsu;Bo Wang;Janaiah Kota;Jianhua Yu

  • Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas

    Huban Kutay;Shoumei Bai;Jharna Datta;Tasneem Motiwala

  • 5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal

    Kalpana Ghoshal;Jharna Datta;Sarmila Majumder;Shoumei Bai

  • Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

    Jharna Datta;Huban Kutay;Mohd W. Nasser;Gerard J. Nuovo

  • TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

    Bo Wang;Shu-Hao Hsu;Sarmila Majumder;Huban Kutay

  • Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer SUPPRESSION OF TUMORIGENIC PROPERTY OF LUNG CANCER CELLS AND THEIR SENSITIZATION TO DOXORUBICIN-INDUCED APOPTOSIS BY miR-1

    Mohd W. Nasser;Jharna Datta;Gerard Nuovo;Huban Kutay

  • Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.

    Sharmistha Pal;Robert A Baiocchi;John C Byrd;Michael R Grever

  • Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.

    Bo Wang;Sarmila Majumder;Gerard Nuovo;Huban Kutay

  • A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

    Jharna Datta;Kalpana Ghoshal;William A. Denny;Swarna A. Gamage

  • A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis

    Praveen Agrawal;Barbara Fontanals-Cirera;Elena Sokolova;Samson Jacob

  • Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.

    Bo Wang;Shu-Hao Hsu;Wendy Frankel;Kalpana Ghoshal

  • A Folate- and Methyl-Deficient Diet Alters the Expression of DNA Methyltransferases and Methyl CpG Binding Proteins Involved in Epigenetic Gene Silencing in Livers of F344 Rats

    Kalpana Ghoshal;Xin Li;Jharna Datta;Shoumei Bai

  • Role of Human Ribosomal RNA (rRNA) Promoter Methylation and of Methyl-CpG-binding Protein MBD2 in the Suppression of rRNA Gene Expression

    Kalpana Ghoshal;Sarmila Majumder;Jharna Datta;Tasneem Motiwala

  • Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

    Kalpana Ghoshal;Jharna Datta;Sarmila Majumder;Shoumei Bai

  • An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

    Kalpana Ghoshal;Samson T. Jacob

  • Regulation of metallothionein gene expression.

    Kalpana Ghoshal;Samson T Jacob

  • Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by α-ananitin

    Samson T. Jacob;Elizabeth M. Sajdel;Hamish N. Munro

Frequent Co-Authors

Kalpana Ghoshal
Kalpana Ghoshal The Ohio State University
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
Gerard J. Nuovo
Gerard J. Nuovo The Ohio State University
Michael R. Grever
Michael R. Grever The Ohio State University
Christoph Plass
Christoph Plass German Cancer Research Center
Bo Yu
Bo Yu Chinese Academy of Sciences
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Carlo M. Croce
Carlo M. Croce The Ohio State University
David Fenyö
David Fenyö New York University

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