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Massimo Negrini

Massimo Negrini

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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
103
Citations
73915
World Ranking
1284
National Ranking
17

Medicine

D-Index
103
Citations
73919
World Ranking
7157
National Ranking
237

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Massimo Negrini is affiliated with the University of Ferrara in Italy and has an extensive research portfolio in biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work covers multiple subfields, including cancer research, molecular biology, pulmonary and respiratory medicine, immunology, and oncology.

Their research focuses on various topics, notably:

  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Circular RNAs in diseases
  • RNA modifications and cancer
  • Chronic Lymphocytic Leukemia Research
  • Extracellular vesicles in disease
  • Cancer, hypoxia, and metabolism

Notable recent publications by Massimo Negrini include:

  • Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells (2020) published in Journal of Extracellular Vesicles
  • P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells (2021) published in Cell Death and Disease
  • MiR-30e-3p Influences Tumor Phenotype through MDM2 / TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma (2020) published in Cancer Research
  • Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis (2021) published in Cell Death and Disease
  • MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma (2023) published in Journal of Experimental & Clinical Cancer Research

Massimo Negrini frequently publishes in venues such as:

  • International Journal of Molecular Sciences
  • Cell Death and Disease
  • Molecular Oncology
  • Molecular Therapy - Nucleic Acids
  • Cancers

The scientist collaborates often with several coauthors, including Cristian Bassi, Manuela Ferracin, Laura Gramantieri, Fabio Piscaglia, and Francesca Fornari, reflecting a strong network of research partnerships.

Best Publications

  • A microRNA expression signature of human solid tumors defines cancer gene targets

    Stefano Volinia;George A. Calin;Chang Gong Liu;Stefan Ambs

  • Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

    George Adrian Calin;Calin Dan Dumitru;Masayoshi Shimizu;Roberta Bichi

  • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

    George Adrian Calin;Cinzia Sevignani;Calin Dan Dumitru;Terry Hyslop

  • MicroRNA gene expression deregulation in human breast cancer.

    Marilena V. Iorio;Manuela Ferracin;Chang Gong Liu;Angelo Veronese

  • miR-15 and miR-16 induce apoptosis by targeting BCL2.

    Amelia Cimmino;George Adrian Calin;Muller Fabbri;Marilena V. Iorio

  • A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

    George Adrian Calin;Manuela Ferracin;Manuela Ferracin;Amelia Cimmino;Gianpiero Di Leva

  • MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

    George Adrian Calin;Chang Gong Liu;Cinzia Sevignani;Manuela Ferracin

  • Extensive modulation of a set of microRNAs in primary glioblastoma.

    S. A. Ciafrè;S. Galardi;A. Mangiola;M. Ferracin

  • A MicroRNA Signature of Hypoxia

    Ritu Kulshreshtha;Manuela Ferracin;Sylwia E. Wojcik;Ramiro Garzon

  • An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

    Chang Gong Liu;George Adrian Calin;Brian Meloon;Nir Gamliel

  • E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

    Fabio Petrocca;Fabio Petrocca;Rosa Visone;Mariadele Rapazzotti Onelli;Manisha H. Shah

  • Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma

    Laura Gramantieri;Manuela Ferracin;Francesca Fornari;Angelo Veronese

  • MiR-15a and miR-16-1 cluster functions in human leukemia.

    George A. Calin;Amelia Cimmino;Muller Fabbri;Manuela Ferracin

  • Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas

    George A. Calin;Chang gong Liu;Manuela Ferracin;Terry Hyslop

  • MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.

    Francesca Fornari;Laura Gramantieri;Manuela Ferracin;A Veronese

  • Micro-RNA profiling in kidney and bladder cancers

    Fedra Gottardo;Chang Gong Liu;Manuela Ferracin;George A. Calin

  • The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer

    Gabriella Sozzi;Maria Luisa Veronese;Massimo Negrini;Raffaele Baffa

  • microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.

    C. Braconi;T. Kogure;T. Kogure;N. Valeri;N. Huang

  • Down-Regulation of bcl-2 by p53 in Breast Cancer Cells

    Subrata Haldar;Massimo Negrini;Maria Monne;Silvia Sabbioni

  • CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

    Hui Ling;Riccardo Spizzo;Yaser Atlasi;Milena Nicoloso

Frequent Co-Authors

Carlo M. Croce
Carlo M. Croce The Ohio State University
George A. Calin
George A. Calin The University of Texas MD Anderson Cancer Center
Giuseppe Barbanti-Brodano
Giuseppe Barbanti-Brodano University of Ferrara
Luigi Bolondi
Luigi Bolondi University of Bologna
Hansjuerg Alder
Hansjuerg Alder The Ohio State University
Stefano Volinia
Stefano Volinia University of Ferrara
Thomas J. Kipps
Thomas J. Kipps University of California, San Diego
Laura Z. Rassenti
Laura Z. Rassenti University of California, San Diego
Giandomenico Russo
Giandomenico Russo Sapienza University of Rome
Antonino Neri
Antonino Neri University of Milan

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