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Overview

Hansjuerg Alder is affiliated with The Ohio State University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, as reflected in their publications and topics of study.

The scientist's work spans several subfields, notably molecular biology, cancer research, immunology, pathology and forensic medicine, and hematology. These areas underline a concentration on the molecular mechanisms underlying disease processes and therapeutic approaches.

Hansjuerg Alder's research covers various topics, including:

  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • RNA modifications and cancer
  • Interferon and immune responses
  • Retinoids in leukemia and cellular processes
  • Cancer mechanisms and therapy
  • Multiple myeloma research and treatments

Their recent scholarly output includes the following papers:

  • Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer, 2022, PLoS ONE
  • Retraction Note: EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers, 2022, Nature Medicine
  • Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development, 2022, Cancer Cell
  • Correction to: MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia, 2022, Oncogene
  • Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development, 2022, Cancer Cell

Their frequent collaborators include:

  • Michela Garofalo
  • Gianpiero Di Leva
  • Stefano Volinia
  • Giulia Romano
  • Carlo M. Croce

Hansjuerg Alder's work has been published mainly in these venues:

  • Cancer Cell
  • PLoS ONE
  • Nature Medicine
  • Oncogene

The focus on microRNA regulation and involvement in cancer biology, particularly lung cancer, leukemia, and multiple myeloma, forms a significant aspect of the scientist's research trajectory. The emphasis on RNA-related mechanisms and their impact on cancer and immune responses marks an integration of molecular biology with therapeutic implications.

Best Publications

  • miR-15 and miR-16 induce apoptosis by targeting BCL2.

    Amelia Cimmino;George Adrian Calin;Muller Fabbri;Marilena V. Iorio

  • A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

    George Adrian Calin;Manuela Ferracin;Manuela Ferracin;Amelia Cimmino;Gianpiero Di Leva

  • MicroRNA Signatures in Human Ovarian Cancer

    Carlo M. Croce

  • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.

    Muller Fabbri;Ramiro Garzon;Amelia Cimmino;Amelia Cimmino;Zhongfa Liu

  • MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

    George Adrian Calin;Chang Gong Liu;Cinzia Sevignani;Manuela Ferracin

  • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

    Muller Fabbri;Alessio Paone;Federica Calore;Roberta Galli

  • MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis.

    Mark Bloomston;Wendy L. Frankel;Fabio Petrocca;Stefano Volinia;Stefano Volinia

  • A MicroRNA Signature of Hypoxia

    Ritu Kulshreshtha;Manuela Ferracin;Sylwia E. Wojcik;Ramiro Garzon

  • The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

    Y. Gu;T. Nakamura;H. Alder;R. Prasad

  • An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

    Chang Gong Liu;George Adrian Calin;Brian Meloon;Nir Gamliel

  • E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

    Fabio Petrocca;Fabio Petrocca;Rosa Visone;Mariadele Rapazzotti Onelli;Manisha H. Shah

  • Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis

    Tetsuya Ueda;Tetsuya Ueda;Stefano Volinia;Stefano Volinia;Hiroshi Okumura;Hiroshi Okumura;Masayoshi Shimizu

  • miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.

    Michela Garofalo;Gianpiero Di Leva;Giulia Romano;Gerard Nuovo

  • MiR-15a and miR-16-1 cluster functions in human leukemia.

    George A. Calin;Amelia Cimmino;Muller Fabbri;Manuela Ferracin

  • Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas

    George A. Calin;Chang gong Liu;Manuela Ferracin;Terry Hyslop

  • The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform

    Kimberly E. Resnick;Hansjuerg Alder;John P. Hagan;Debra L. Richardson

  • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

    Ramiro Garzon;Stefano Volinia;Stefano Volinia;Chang-Gong Liu;Cecilia Fernandez-Cymering

  • MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

    Flavia Pichiorri;Sung Suk Suh;Marco Ladetto;Michael Kuehl

  • MicroRNA fingerprints during human megakaryocytopoiesis

    Carlo M. Croce;Ramiro Garzon;George A. Calin

  • p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

    Taewan Kim;Angelo Veronese;Flavia Pichiorri;Tae Jin Lee

Frequent Co-Authors

Carlo M. Croce
Carlo M. Croce The Ohio State University
Stefano Volinia
Stefano Volinia University of Ferrara
Massimo Negrini
Massimo Negrini University of Ferrara
George A. Calin
George A. Calin The University of Texas MD Anderson Cancer Center
Rami I. Aqeilan
Rami I. Aqeilan Hebrew University of Jerusalem
Laura Z. Rassenti
Laura Z. Rassenti University of California, San Diego
Thomas J. Kipps
Thomas J. Kipps University of California, San Diego
Kay Huebner
Kay Huebner The Ohio State University
Gerard J. Nuovo
Gerard J. Nuovo The Ohio State University
Masaki Mori
Masaki Mori Kyushu University

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