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Dieter Seebach

Dieter Seebach

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Chemistry
Switzerland
2026

D-Index & Metrics

Chemistry

D-Index
132
Citations
75855
World Ranking
289
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Chemistry in Switzerland Leader Award
  • 2025 - Research.com Chemistry in Switzerland Leader Award
  • 2022 - Research.com Chemistry in Switzerland Leader Award
  • 2019 - Arthur C. Cope Award, American Chemical Society (ACS)
  • 2007 - Member of the National Academy of Sciences
  • 2004 - Ryoji Noyori Prize, Society of Synthetic Organic Chemistry
  • 2003 - Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry, Elsevier
  • 2002 - Chirality Medal, Società Chimica Italiana Switzerland
  • 1990 - Centenary Prize, Royal Society of Chemistry (UK)
  • 1984 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Chemistry

Overview

Dieter Seebach is affiliated with ETH Zurich in Switzerland. Their research spans multiple areas within biochemistry, genetics, molecular biology, and materials science. The subfields they contribute to include molecular biology, pharmacology, materials chemistry, biochemistry, and biomaterials.

Their work focuses on several key topics: microbial natural products and biosynthesis, photosynthetic processes and mechanisms, enzyme structure and function, biochemical acid research studies, biodegradable polymer synthesis and properties, enzyme catalysis and immobilization, as well as parasitic infections and diagnostics.

Recent scholarly contributions by Dieter Seebach include:

  • Structures and function of the amino acid polymerase cyanophycin synthetase, 2021, Nature Chemical Biology
  • No Life on this Planet Without PHB, 2023, Helvetica Chimica Acta
  • A simple and efficient transfection protocol for Cryptosporidium parvum using Polyethylenimine (PEI) and Octaarginine, 2020, Parasitology

Their frequent co-authors include:

  • Itai Sharon
  • Asfarul S. Haque
  • Marcel Grogg
  • Indrajit Lahiri
  • Andrés E. Leschziner

Publication venues where their work appears regularly are:

  • Nature Chemical Biology
  • Helvetica Chimica Acta
  • Parasitology

Dieter Seebach has received multiple awards over their career including:

  • Arthur C. Cope Award, American Chemical Society (ACS) in 2019
  • Member of the National Academy of Sciences in 2007
  • Ryoji Noyori Prize, Society of Synthetic Organic Chemistry in 2004
  • Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry, Elsevier in 2003
  • Chirality Medal, Società Chimica Italiana in 2002 (Switzerland)
  • Centenary Prize, Royal Society of Chemistry (UK) in 1990
  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften in 1984 (Chemistry)

Best Publications

  • Peptide Folding: When Simulation Meets Experiment

    Xavier Daura;Karl Gademann;Bernhard Jaun;Dieter Seebach

  • Methods of Reactivity Umpolung

    Dieter Seebach

  • The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components.

    Dieter Seebach;Albert K Beck;Daniel J Bierbaum

  • Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures

    Dieter Seebach

  • β-Peptides: a surprise at every turn

    Dieter Seebach;Jennifer L. Matthews

  • β-Peptides: Synthesis by Arndt-Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X-ray crystallography. Helical secondary structure of a β-hexapeptide in solution and its stability towards pepsin

    Dieter Seebach;Mark Overhand;Florian N. M. Kühnle;Bruno Martinoni

  • Generation and synthetic applications of 2-lithio-1,3-dithianes

    Dieter Seebach;Elias J. Corey

  • β-Peptidic Peptidomimetics

    Dieter Seebach;James Gardiner

  • TADDOLs, Their Derivatives, and TADDOL Analogues: Versatile Chiral Auxiliaries

    Dieter Seebach;Albert K. Beck;Alexander Heckel

  • Umpolung of the Reactivity of Carbonyl Compounds Through Sulfur-Containing Reagents

    Bengt-Thomas Gröbel;Dieter Seebach

  • Organic Synthesis—Where now?

    Dieter Seebach

  • Methoden der Reaktivitätsumpolung

    Dieter Seebach

  • Self-Regeneration of Stereocenters (SRS)—Applications, Limitations, and Abandonment of a Synthetic Principle†‡

    Dieter Seebach;Andrea R. Sting;Matthias Hoffmann

  • The Outstanding Biological Stability of β‐ and γ‐Peptides toward Proteolytic Enzymes: An In Vitro Investigation with Fifteen Peptidases

    Jens Frackenpohl;Per I. Arvidsson;Jürg V. Schreiber;Dieter Seebach

  • Alkylation of amino acids without loss of the optical activity: preparation of .alpha.-substituted proline derivatives. A case of self-reproduction of chirality

    D. Seebach;M. Boes;R. Naef;W. B. Schweizer

  • Poly(hydroxyalkanoates): A Fifth Class of Physiologically Important Organic Biopolymers?†

    Hans-Martin Müller;Dieter Seebach

  • Synthesis of Open-Chain 2,3-Disubstituted 4-nitroketones by Diastereoselective Michael-addition of (E)-Enamines to (E)-Nitroolefins. A topological rule for C, C-bond forming processes between prochiral centres. Preliminary communication

    Dieter Seebach;Jerzy Goliński

  • Probing the Helical Secondary Structure of Short‐Chain β‐Peptides

    Dieter Seebach;Paola E. Ciceri;Mark Overhand;Bernhard Jaun

  • The Unambiguous Specification of the Steric Course of Asymmetric Syntheses

    Dieter Seebach;Vladimir Prelog

  • 13C‐NMR.‐Spektroskopie von Organolithiumverbindungen bei tiefen Temperaturen. Strukturinformation aus der 13C, 6Li‐Kopplung

    Dieter Seebach;Robert Hässig;Josef Gabriel

Frequent Co-Authors

Magnus Rueping
Magnus Rueping King Abdullah University of Science and Technology
Bernhard Jaun
Bernhard Jaun ETH Zurich
Karl Gademann
Karl Gademann University of Zurich
Dieter Enders
Dieter Enders RWTH Aachen University
Jack D. Dunitz
Jack D. Dunitz ETH Zurich
Philippe Renaud
Philippe Renaud École Polytechnique Fédérale de Lausanne
Eusebio Juaristi
Eusebio Juaristi Instituto Politécnico Nacional
Hans-Peter E. Kohler
Hans-Peter E. Kohler Swiss Federal Institute of Aquatic Science and Technology
Daniel Hoyer
Daniel Hoyer University of Melbourne

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