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Overview

Gilles Guichard is a researcher affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their work primarily spans the fields of Materials Science and Biochemistry, Genetics and Molecular Biology, with a focus on the subfields of Materials Chemistry, Molecular Biology, and Organic Chemistry. The scientist's research also touches on Biomaterials and Microbiology.

Their research topics are broadly centered on Chemical Synthesis and Analysis, Crystallization and Solubility Studies, and X-ray Diffraction in Crystallography. Additional topics include Click Chemistry and Applications, RNA and protein synthesis mechanisms, Antimicrobial Peptides and Activities, and Carbon dioxide utilization in catalysis.

Guichard has published extensively, including notable papers such as:

  • Structural Basis for α-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers, 2020, Angewandte Chemie International Edition
  • A chiral thiourea and a phosphazene for fast and stereoselective organocatalytic ring-opening-polymerization of racemic lactide, 2021, Chemical Communications
  • Reaching High Stereoselectivity and Activity in Organocatalyzed Ring-Opening Polymerization of Racemic Lactide by the Combined Use of a Chiral (Thio)Urea and a N-Heterocyclic Carbene, 2022, ACS Macro Letters
  • Nature-inspired synthetic oligourea foldamer channels allow water transport with high salt rejection, 2023, Chem
  • Structural Effect of Organic Catalytic Pairs Based on Chiral Amino(thio)ureas and Phosphazene Bases for the Isoselective Ring-Opening Polymerization of Racemic Lactide, 2023, Macromolecules

Frequent co-authors include:

  • Gavin W. Collie
  • Sung Hyun Yoo
  • Morgane Pasco
  • Jérémie Buratto
  • Brice Kauffmann

Their research has frequently been published in specialized venues such as The Cambridge Structural Database, Chemistry - A European Journal, Chemical Communications, Angewandte Chemie International Edition, and Journal of Medicinal Chemistry.

Best Publications

  • β2- and β3-Peptides with Proteinaceous Side Chains: Synthesis and solution structures of constitutional isomers, a novel helical secondary structure and the influence of solvation and hydrophobic interactions on folding

    Dieter Seebach;Stefan Abele;Karl Gademann;Gilles Guichard

  • Synthetic foldamers.

    Unknown

  • N,N'-linked oligoureas as foldamers: chain length requirements for helix formation in protic solvent investigated by circular dichroism, NMR spectroscopy, and molecular dynamics.

    Aude Violette;Marie Christine Averlant-Petit;Vincent Semetey;Christine Hemmerlin

  • Antigenic mimicry of natural L-peptides with retro-inverso-peptidomimetics.

    G. Guichard;N. Benkirane;G. Zeder-Lutz;M. H. V. Van Regenmortel

  • Preparation of N-Fmoc-Protected β2- and β3-Amino Acids and their use as building blocks for the solid-phase synthesis of β-peptides†‡

    Gilles Guichard;Stefan Abele;Dieter Seebach

  • The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

    A Carolin Seefeldt;A Carolin Seefeldt;Fabian Nguyen;Stéphanie Antunes;Natacha Pérébaskine;Natacha Pérébaskine

  • Proline-rich antimicrobial peptides targeting protein synthesis

    Michael Graf;Mario Mardirossian;Fabian Nguyen;A. Carolin Seefeldt

  • Consequences of Isostructural Main‐Chain Modifications for the Design of Antimicrobial Foldamers: Helical Mimics of Host‐Defense Peptides Based on a Heterogeneous Amide/Urea Backbone

    Paul Claudon;Aude Violette;Karen Lamour;Marion Decossas

  • Folding and self-assembly of aromatic and aliphatic urea oligomers: towards connecting structure and function.

    Lucile Fischer;Gilles Guichard

  • Mimicking helical antibacterial peptides with nonpeptidic folding oligomers.

    Aude Violette;Sylvie Fournel;Karen Lamour;Olivier Chaloin

  • Antigenicity and immunogenicity of modified synthetic peptides containing D-amino acid residues. Antibodies to a D-enantiomer do recognize the parent L-hexapeptide and reciprocally.

    N. Benkirane;M. Friede;G. Guichard;J.-P. Briand

  • Anion-macrodipole interactions: self-assembling oligourea/amide macrocycles as anion transporters that respond to membrane polarization.

    Andreas Hennig;Lucile Fischer;Gilles Guichard;Stefan Matile

  • Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation

    Gavin W. Collie;Gavin W. Collie;Karolina Pulka-Ziach;Karolina Pulka-Ziach;Karolina Pulka-Ziach;Caterina M. Lombardo;Caterina M. Lombardo;Juliette Fremaux;Juliette Fremaux;Juliette Fremaux

  • Stable Helical Secondary Structure in Short‐Chain N,N′‐Linked Oligoureas Bearing Proteinogenic Side Chains

    Vincent Semetey;Didier Rognan;Christine Hemmerlin;Roland Graff

  • The canonical helix of urea oligomers at atomic resolution: insights into folding-induced axial organization.

    Lucile Fischer;Paul Claudon;Nagendar Pendem;Emeric Miclet

  • (S)-β3-Homolysine- and (S)-β3-Homoserine-Containingβ-Peptides: CD Spectra in Aqueous Solution

    Stefan Abele;Gilles Guichard;Dieter Seebach

  • Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C–C Bond-Forming Reactions

    Diane Bécart;Diane Bécart;Vincent Diemer;Arnaud Salaün;Mikel Oiarbide

  • Self‐Assembling Organic Nanotubes from Enantiopure Cyclo‐N,N′‐Linked Oligoureas: Design, Synthesis, and Crystal Structure

    Vincent Semetey;Claude Didierjean;Jean-Paul Briand;André Aubry

  • Identification of V3 Loop-binding Proteins as Potential Receptors Implicated in the Binding of HIV Particles to CD4+Cells

    Christian Callebaut;Julià Blanco;Nadia Benkirane;Bernard Krust

  • The Anti-HIV Pseudopeptide HB-19 Forms a Complex with the Cell-surface-expressed Nucleolin Independent of Heparan Sulfate Proteoglycans

    Sébastien Nisole;Bernard Krust;Christian Callebaut;Gilles Guichard

  • Effective Preparation of O-Succinimidyl-2- (tert-butoxycarbonylamino)ethylcarbamate Derivatives from β-Amino Acids. Application to the Synthesis of Urea-Containing Pseudopeptides and Oligoureas†

    Gilles Guichard;Vincent Semetey;Claude Didierjean;André Aubry

Frequent Co-Authors

Jean-Paul Briand
Jean-Paul Briand Centre national de la recherche scientifique, CNRS
Sylviane Muller
Sylviane Muller University of Strasbourg
Brice Kauffmann
Brice Kauffmann University of Bordeaux
Alberto Bianco
Alberto Bianco University of Strasbourg
Stéphane Bellemin-Laponnaz
Stéphane Bellemin-Laponnaz University of Strasbourg
Johan Hoebeke
Johan Hoebeke Centre national de la recherche scientifique, CNRS
Ara G. Hovanessian
Ara G. Hovanessian Centre national de la recherche scientifique, CNRS
Michel Marraud
Michel Marraud Centre national de la recherche scientifique, CNRS
Pascal Schneider
Pascal Schneider University of Lausanne
M.H.V. Van Regenmortel
M.H.V. Van Regenmortel University of Strasbourg

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