World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Genetics
Spain
2026

D-Index & Metrics

Best Scientists

D-Index
177
Citations
144197
World Ranking
667
National Ranking
5

Genetics

D-Index
182
Citations
149575
World Ranking
43
National Ranking
1

Medicine

D-Index
183
Citations
150873
World Ranking
324
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Genetics in Spain Leader Award
  • 2026 - Research.com Medicine in Spain Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Genetics in Spain Leader Award
  • 2025 - Research.com Medicine in Spain Leader Award
  • 2024 - Research.com Genetics in Spain Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Spain Leader Award
  • 2023 - Research.com Genetics in Spain Leader Award
  • 2023 - Research.com Medicine in Spain Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Spain Leader Award
  • 2022 - Research.com Medicine in Spain Leader Award

Overview

Manel Esteller is affiliated with the Josep Carreras Leukaemia Research Institute in Spain. Their research spans multiple areas within the life sciences, with a primary focus on biochemistry, genetics, and molecular biology, supported by 372 publications in these fields. Medicine is another significant area of their work, with 232 publications.

The scientist's research includes extensive contributions to molecular biology, cancer research, and genetics. Specific subfields of study include:

  • Molecular Biology
  • Cancer Research
  • Genetics
  • Oncology
  • Immunology

Key topics addressed in the body of work encompass epigenetics and DNA methylation, RNA modifications, cancer genomics and diagnostics, and cancer-related molecular mechanisms and gene regulation. They have also contributed to studies on genetics and neurodevelopmental disorders and acute myeloid leukemia research:

  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cancer Genomics and Diagnostics
  • Cancer-related molecular mechanisms research
  • Cancer-related gene regulation
  • Genetics and Neurodevelopmental Disorders
  • Acute Myeloid Leukemia Research

Frequent publication venues for the scientist include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Nature Communications
  • Cancer Research
  • Molecular Oncology

Their recent papers highlight themes in epigenetics, cancer biology, and immunology. Recent publications include:

  • "Sarcoma classification by DNA methylation profiling," 2021, Nature Communications
  • "The Contribution of Epigenetics to Cancer Immunotherapy," 2020, Trends in Immunology
  • "Cancer epigenetics in clinical practice," 2022, CA A Cancer Journal for Clinicians
  • "Accelerated biological aging in COVID-19 patients," 2022, Nature Communications
  • "Writers, readers and erasers of RNA modifications in cancer," 2020, Cancer Letters

Manel Esteller often collaborates with a group of frequent coauthors, including:

  • Verónica Dávalos
  • Carlos A. García-Prieto
  • Manuel Castro de Moura
  • Arcadi Navarro
  • Carolina Minguillón

Best Publications

  • Non-coding RNAs in human disease

    Manel Esteller

  • Epigenetics in Cancer

    Manel Esteller

  • Epigenetic differences arise during the lifetime of monozygotic twins

    Mario F. Fraga;Esteban Ballestar;Maria F. Paz;Santiago Ropero

  • Epigenetic modifications and human disease

    Anna Portela;Manel Esteller

  • A Gene Hypermethylation Profile of Human Cancer

    Manel Esteller;Manel Esteller;Paul G. Corn;Stephen B. Baylin;James G. Herman

  • Cancer epigenomics: DNA methylomes and histone-modification maps

    Manel Esteller

  • Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents

    Manel Esteller;Jesus Garcia-Foncillas;Esther Andion;Steven N. Goodman

  • The Polycomb group protein EZH2 directly controls DNA methylation

    Emmanuelle Viré;Carmen Brenner;Rachel Deplus;Loïc Blanchon

  • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

    Mario F Fraga;Esteban Ballestar;Ana Villar-Garea;Manuel Boix-Chornet

  • Human polymorphism at microRNAs and microRNA target sites.

    Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang

  • Gene-Expression Profiles in Hereditary Breast Cancer

    I Hedenfalk;D Duggan;Y Chen;M Radmacher

  • A Landscape of Pharmacogenomic Interactions in Cancer

    Francesco Iorio;Francesco Iorio;Theo A. Knijnenburg;Theo A. Knijnenburg;Daniel J. Vis;Graham R. Bignell

  • Global Epigenomic Reconfiguration During Mammalian Brain Development

    Ryan Lister;Ryan Lister;Eran A. Mukamel;Joseph R. Nery;Mark Urich

  • DNA methylation and cancer.

    Marta Kulis;Manel Esteller

  • CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future.

    Manel Esteller

  • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

    Manel Esteller;Stanley R. Hamilton;Peter C. Burger;Stephen B. Baylin

  • Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

    Manel Esteller;Jose Maria Silva;Gemma Dominguez;Felix Bonilla

  • Cancer epigenetics reaches mainstream oncology

    Manuel Rodríguez-Paredes;Manel Esteller;Manel Esteller

  • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.

    Victoria Bolós;Hector Peinado;Mirna A Pérez-Moreno;Mirna A Pérez-Moreno;Mario F Fraga

  • A microRNA DNA methylation signature for human cancer metastasis

    Amaia Lujambio;George A. Calin;Alberto Villanueva;Santiago Ropero

Frequent Co-Authors

Mario F. Fraga
Mario F. Fraga University of Oviedo
Esteban Ballestar
Esteban Ballestar University of Valencia
James G. Herman
James G. Herman University of Pittsburgh
Holger Heyn
Holger Heyn Pompeu Fabra University
Alberto Villanueva
Alberto Villanueva Memorial Sloan Kettering Cancer Center
Agustín F. Fernández
Agustín F. Fernández University of Oviedo
Stephen B. Baylin
Stephen B. Baylin Johns Hopkins University
Gabriel Capellá
Gabriel Capellá Institut d'Investigació Biomédica de Bellvitge
Josep M. Llovet
Josep M. Llovet University of Barcelona
August Vidal
August Vidal University of Barcelona

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