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Overview

Gabriel Capellá is a researcher affiliated with the Institut d'Investigació Biomédica de Bellvitge in Spain. Their body of work spans significant contributions primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology.

Capellá's research encompasses several subfields, including Pathology and Forensic Medicine, Genetics, Oncology, Cancer Research, and Molecular Biology. Their investigations often focus on genetic factors influencing cancer development and progression, with a particular emphasis on colorectal cancer.

The main research topics addressed include:

  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Genomics and Rare Diseases
  • Colorectal Cancer Screening and Detection
  • Colorectal and Anal Carcinomas
  • Genomic variations and chromosomal abnormalities
  • BRCA gene mutations in cancer

Frequent publication venues for Capellá's work include:

  • European Journal of Human Genetics
  • Gastroenterology
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medical Genetics

Recent representative papers illustrate a focus on genetic contributions to cancer susceptibility and diagnostic evaluation:

  • "Role of POLE and POLD1 in familial cancer" (2020), Genetics in Medicine
  • "Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome" (2020), European Journal of Human Genetics
  • "Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19" (2021), Frontiers in Immunology
  • "Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study" (2021), The Lancet Oncology
  • "Evaluation of CNV detection tools for NGS panel data in genetic diagnostics" (2020), European Journal of Human Genetics

Gabriel Capellá has collaborated extensively with other researchers, including Marta Pineda, Joan Brunet, Conxi Lázaro, Laura Valle, and Jesús Del Valle, reflecting an active engagement in collaborative scientific endeavors.

Best Publications

  • Peutz–Jeghers syndrome: a systematic review and recommendations for management

    A. D. Beggs;A. R. Latchford;H. F. A. Vasen;G. Moslein

  • Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

    Hans F A Vasen;Ignacio Blanco;Katja Aktan-Collan;Jessica P Gopie

  • Guidelines for the clinical management of familial adenomatous polyposis (FAP)

    H. F. A Vasen;G. Moslein;A. Alonso;S. Aretz

  • Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

    Hans F.A. Vasen;Gabriele Möslein;Angel Alonso;Inge Bernstein

  • Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

    Manel Esteller;Andrew Sparks;Minoru Toyota;Montserrat Sanchez-Cespedes

  • Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

    Albert Tenesa;Susan M Farrington;James G D Prendergast;Mary E Porteous

  • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

    Manel Esteller;Minoru Toyota;Montserrat Sanchez-Cespedes;Gabriel Capella

  • Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

    Ramon Salazar;Paul Roepman;Gabriel Capella;Victor Moreno

  • Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

    Manel Esteller;Silvia Tortola;Minoru Toyota;Gabriel Capella

  • DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

    Manel Esteller;Mario F. Fraga;Mingzhou Guo;Jesus Garcia-Foncillas

  • Recent advances in cancer therapy: an overview.

    A. Urruticoechea;R. Alemany;J. Balart;A. Villanueva

  • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

    Pål Møller;Toni T Seppälä;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

    Pal Moller;Toni Seppala;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

    Mev Dominguez-Valentin;Julian R. Sampson;Toni T. Seppälä;Sanne W. ten Broeke

  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Bryony A Thompson;Bryony A Thompson;Amanda B Spurdle;John-Paul Plazzer;Marc S Greenblatt

  • Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

    Sonia A Melo;Santiago Ropero;Catia Moutinho;Lauri A Aaltonen

  • Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer.

    Stefano Landi;Victor Moreno;Lydie Gioia-Patricola;Elisabeth Guino

  • A DNA methylation fingerprint of 1628 human samples

    Augustin F. Fernandez;Yassen Assenov;Jose Ignacio Martin-Subero;Balazs Balint

  • Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

    Verónica Rodilla;Alberto Villanueva;Antonia Obrador-Hevia;Àlex Robert-Moreno

  • Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers

    Jairo Rodriguez;Jordi Frigola;Elisenda Vendrell;Rosa Ana Risques

Frequent Co-Authors

Victor Moreno
Victor Moreno University of Barcelona
Conxi Lázaro
Conxi Lázaro Institut d'Investigació Biomédica de Bellvitge
Miguel A. Peinado
Miguel A. Peinado Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute
Alberto Villanueva
Alberto Villanueva Memorial Sloan Kettering Cancer Center
Pål Møller
Pål Møller Oslo University Hospital
Hans F. A. Vasen
Hans F. A. Vasen Leiden University
Julian Roy Sampson
Julian Roy Sampson Cardiff University
John Burn
John Burn Newcastle University
Eivind Hovig
Eivind Hovig University of Oslo

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