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Medicine

D-Index
103
Citations
42872
World Ranking
7311
National Ranking
712

Overview

John Burn is affiliated with Newcastle University in the United Kingdom and has a research profile primarily focused on medicine, with significant contributions to biochemistry, genetics, and molecular biology. Their work spans several subfields, including pathology and forensic medicine, oncology, cancer research, molecular biology, and genetics.

The research topics covered by John Burn emphasize genetic factors in colorectal cancer, cancer genomics and diagnostics, colorectal cancer screening and detection, colorectal cancer treatments and studies, colorectal and anal carcinomas, genomics and rare diseases, and multiple and secondary primary cancers.

John Burn's recent papers include:

  • Whole-genome sequencing of patients with rare diseases in a national health system, 2020, Nature
  • Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial, 2020, The Lancet

Frequent co-authors collaborating with John Burn include:

  • Richard Gallon
  • D. Gareth Evans
  • Toni T. Seppälä
  • Gabriela Möslein
  • Mev Dominguez-Valentin

John Burn has published extensively in a variety of scientific journals. Common publication venues include:

  • British Journal of Dermatology
  • Hereditary Cancer in Clinical Practice
  • Genetics in Medicine
  • British journal of surgery
  • Cancers

Among the noteworthy topics addressed in their research are the genetic and molecular aspects of colorectal cancer and the development of effective screening and diagnostic protocols. The focus on hereditary colorectal cancer syndromes, particularly Lynch syndrome, has been a critical area, demonstrated by work on long-term aspirin use in cancer prevention and studies on colorectal cancer risk variation within affected families.

John Burn's interdisciplinary approach combines clinical oncology, molecular biology, and genetics to explore cancer development and prevention strategies. Their research contributes to the understanding of complex genetic factors in disease susceptibility and the improvement of patient outcomes through genomic diagnostics and targeted treatments.

Best Publications

  • Celecoxib for the Prevention of Sporadic Colorectal Adenomas

    Monica M. Bertagnolli;Craig J. Eagle;Ann G. Zauber;Mark Redston

  • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

    John Burn;Anne Marie Gerdes;Finlay MacRae;Jukka Pekka Mecklin

  • A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage.

    J Bamford;P Sandercock;M Dennis;J Burn

  • Peutz–Jeghers syndrome: a systematic review and recommendations for management

    A. D. Beggs;A. R. Latchford;H. F. A. Vasen;G. Moslein

  • Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

    Jack Cuzick;Florian Otto;Florian Otto;John A Baron;Powel H Brown

  • Cancer Risk Associated with Germline DNA Mismatch Repair Gene Mutations

    Malcolm G. Dunlop;Susan M. Farrington;Susan M. Farrington;Andrew D. Carothers;Andrew H. Wyllie

  • Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

    Hans F A Vasen;Ignacio Blanco;Katja Aktan-Collan;Jessica P Gopie

  • Identification of the familial cylindromatosis tumour-suppressor gene.

    Graham R. Bignell;William Warren;Sheila Seal;Meiko Takahashi

  • Guidelines for the clinical management of familial adenomatous polyposis (FAP)

    H. F. A Vasen;G. Moslein;A. Alonso;S. Aretz

  • Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project.

    John Burn;Martin Dennis;John Bamford;Peter Sandercock

  • Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

    Hans F.A. Vasen;Gabriele Möslein;Angel Alonso;Inge Bernstein

  • DiGeorge syndrome: part of CATCH 22.

    D I Wilson;J Burn;P Scambler;J Goodship

  • Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.

    Andrew R.J. Curtis;Constanze Fey;Christopher M Morris;Laurence A. Bindoff

  • Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

    Helen M. Arthur;Jan Ure;Andrew J.H. Smith;Glenn Renforth

  • Epileptic seizures after a first stroke: the Oxfordshire community stroke project

    John Burn;Martin Dennis;John Bamford;Peter Sandercock

  • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

    Pål Møller;Toni T Seppälä;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

    Pal Moller;Toni Seppala;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

    Mev Dominguez-Valentin;Julian R. Sampson;Toni T. Seppälä;Sanne W. ten Broeke

  • European Code Against Cancer and scientific justification: third version (2003)

    P. Boyle;P. Autier;H. Bartelink;J. Baselga

  • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer

    John Burn;Anne-Marie Gerdes;Finlay Macrae;Jukka-Pekka Mecklin

Frequent Co-Authors

Judith A. Goodship
Judith A. Goodship Newcastle University
John C. Mathers
John C. Mathers Newcastle University
Hans F. A. Vasen
Hans F. A. Vasen Leiden University
D. Gareth Evans
D. Gareth Evans University of Manchester
Julian Roy Sampson
Julian Roy Sampson Cardiff University
Pål Møller
Pål Møller Oslo University Hospital
Jukka-Pekka Mecklin
Jukka-Pekka Mecklin University of Jyväskylä
Peter J. Scambler
Peter J. Scambler University College London
Annika Lindblom
Annika Lindblom Karolinska Institute
Fiona Lalloo
Fiona Lalloo University of Manchester

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