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Genetics

D-Index
75
Citations
25272
World Ranking
1888
National Ranking
237

Overview

Fiona Lalloo is affiliated with the University of Manchester in the United Kingdom. Their research focuses primarily on genetics and oncology, with a broad scope encompassing molecular biology and cancer research.

Their recent publications cover a range of topics related to genetic predispositions, cancer genetics, and molecular mechanisms. Notable papers include:

  • Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4/BMPR1A pathogenic variant carriers (2020, Genetics in Medicine)
  • Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis (2020, New England Journal of Medicine)
  • Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells (2022, Nature Communications)
  • Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group (2021, Familial Cancer)
  • The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant (2021, Genetics in Medicine)

The core topics of Fiona Lalloo's work include:

  • BRCA gene mutations in cancer
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Global Cancer Incidence and Screening
  • Ovarian cancer diagnosis and treatment
  • Genomic variations and chromosomal abnormalities

Lalloo's research is published frequently in the following venues:

  • Journal of Medical Genetics
  • Genetics in Medicine
  • Cancers
  • Familial Cancer
  • European Journal of Human Genetics

Collaboration is a significant aspect of their work, with frequent co-authors including:

  • D. Gareth Evans
  • Emma R. Woodward
  • Anthony Howell
  • Sacha J. Howell
  • Elaine F. Harkness

Fiona Lalloo's main fields of study reflect an interdisciplinary approach involving:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of particular focus within their research include:

  • Genetics
  • Oncology
  • Cancer Research
  • Pathology and Forensic Medicine
  • Molecular Biology

Best Publications

  • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies

    A. Antoniou;P.D.P. Pharoah;S. Narod;H.A. Risch

  • Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service.

    D.G. Evans;E. Howard;E. Howard;C. Giblin;C. Giblin;T. Clancy;T. Clancy

  • Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

    Sunil R. Lakhani;Jorge S. Reis-Filho;Laura Fulford;Frederique Penault-Llorca

  • The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.

    A C Antoniou;A P Cunningham;J Peto;D G Evans

  • Germline mutations in RAD51D confer susceptibility to ovarian cancer

    Chey Loveday;Clare Turnbull;Emma Ramsay;Deborah Hughes

  • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

    Pål Møller;Toni T Seppälä;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

    Pal Moller;Toni Seppala;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

    Mev Dominguez-Valentin;Julian R. Sampson;Toni T. Seppälä;Sanne W. ten Broeke

  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Bryony A Thompson;Bryony A Thompson;Amanda B Spurdle;John-Paul Plazzer;Marc S Greenblatt

  • Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations in SDHB and SDHD

    Christopher J. Ricketts;Julia R. Forman;Eleanor Rattenberry;Nicola Bradshaw

  • Whole-genome sequencing of patients with rare diseases in a national health system

    Ernest Turro;William J Astle;Karyn Megy;Stefan Graf

  • Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

    Kevin J Monahan;Nicola Bradshaw;Sunil Dolwani;Bianca Desouza

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations

    Emma Barrow;L. Robinson;W. Alduaij;A. Shenton

  • Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme

    E Amir;D G Evans;A Shenton;F Lalloo

  • Risk of cancer other than breast or ovarian in individuals with BRCA1 and BRCA2 mutations.

    Anthony Moran;C O'Hara;S Khan;Lorraine G Shack

  • Haplotype and phenotype analysis of nine recurrent BRCA2 mutations in 111 families: results of an international study

    Susan L. Neuhausen;Sylvie Mazoyer;Lori Friedman;Michael Stratton

  • Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

    Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Lesley McGuffog;Daniel Barrowdale;Andrew Lee

  • A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO.

    D G R Evans;D M Eccles;N Rahman;K Young

  • Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

    D Gareth R Evans;Andrew Shenton;Emma Woodward;Fiona Lalloo

Frequent Co-Authors

D. Gareth Evans
D. Gareth Evans University of Manchester
Anthony Howell
Anthony Howell University of Manchester
Antonis C. Antoniou
Antonis C. Antoniou University of Cambridge
Diana Eccles
Diana Eccles University of Southampton
Douglas F. Easton
Douglas F. Easton University of Cambridge
Heli Nevanlinna
Heli Nevanlinna University of Helsinki
Paolo Radice
Paolo Radice Fondazione IRCCS Istituto Nazionale dei Tumori
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute

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