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Dominique Stoppa-Lyonnet

Dominique Stoppa-Lyonnet

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Genetics
France
2024
Award Badge
Genetics and Molecular Biology
France
2024

D-Index & Metrics

Genetics

D-Index
102
Citations
47705
World Ranking
697
National Ranking
15

Medicine

D-Index
104
Citations
48956
World Ranking
6958
National Ranking
213

Research.com Recognitions

  • 2024 - Research.com Genetics in France Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award

Overview

Dominique Stoppa-Lyonnet is affiliated with the Institute Curie in France and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. The scope of their research spans several subfields, including genetics, molecular biology, cancer research, oncology, and pathology and forensic medicine.

Their publication record includes significant work within genetics and cancer biology, focusing on the molecular mechanisms underlying cancer development and diagnostic approaches. The main topics covered in their research are:

  • BRCA gene mutations in cancer
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Genetic factors in colorectal cancer
  • CRISPR and Genetic Engineering
  • Genetic Associations and Epidemiology
  • Nutrition, Genetics, and Disease

Stoppa-Lyonnet has published in various notable venues, frequently contributing to:

  • Journal of Medical Genetics
  • Cancers
  • Cancer Research
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)

Collaborative work is a key feature of their research, with frequent coauthors including Lisa Golmard, Chrystelle Colas, Ivan Bièche, Fabienne Lesueur, and Nadine Andrieu. These partnerships have supported an extensive range of studies addressing genetic and molecular aspects of cancer.

Stoppa-Lyonnet's recent papers illustrate ongoing engagement with pivotal topics in cancer genetics and diagnostics. Selected recent publications include:

  • Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants, 2020, Genetics in Medicine
  • COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area, 2020, Breast Cancer Research
  • A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression, 2021, Nature Communications
  • Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images, 2022, Cell Reports Medicine
  • ShallowHRD: detection of homologous recombination deficiency from shallow whole genome sequencing, 2020, Bioinformatics

The body of work produced by Dominique Stoppa-Lyonnet reflects a sustained focus on the genetic factors influencing cancer susceptibility and progression, with particular attention to BRCA-related cancer risks and applications of advanced computational methods in diagnostics.

Best Publications

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

    S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack

  • Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

    D Ford;D F Easton;M Stratton;S Narod

  • Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

    Karoline B. Kuchenbaecker;Karoline B. Kuchenbaecker;John L. Hopper;Daniel R. Barnes;Kelly-Anne Phillips

  • The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.

    S.V. Tavtigian;J. Simard;J. Rommens;F. Couch

  • Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations

    Sunil R. Lakhani;Jocelyne Jacquemier;John P Sloane;Barry A. Gusterson

  • Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a BRCA1 or BRCA2 Mutation

    Amy Finch;Mario Beiner;Jan Lubinski;Henry T. Lynch

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • Protein interaction mapping: A Drosophila case study

    Etienne Formstecher;Sandra Aresta;Vincent Collura;Alexandre Hamburger

  • Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study

    Steven A. Narod;Jean Sébastien Brunet;Parviz Ghadirian;Mark Robson

  • Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

    Gaëlle Bougeard;Mariette Renaux-Petel;Jean-Michel Flaman;Camille Charbonnier

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

    Tatiana Popova;Elodie Manié;Guillaume Rieunier;Virginie Caux-Moncoutier

  • A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

    Corine Bertolotto;Fabienne Lesueur;Sandy Giuliano;Thomas Strub

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Prevalence of p16 and CDK4 Germline Mutations in 48 Melanoma-Prone Families in France

    Nadem Soufir;Marie-Françoise Avril;Agnès Chompret;Florence Demenais

  • 2009 version of the Chompret criteria for Li Fraumeni syndrome.

    Julie Tinat;Gaelle Bougeard;Stéphanie Baert-Desurmont;Stéphanie Vasseur

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

Frequent Co-Authors

Claude Houdayer
Claude Houdayer Centre Hospitalier Universitaire de Rouen
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Douglas F. Easton
Douglas F. Easton University of Cambridge
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Rita K. Schmutzler
Rita K. Schmutzler University of Cologne
Antonis C. Antoniou
Antonis C. Antoniou University of Cambridge
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Eitan Friedman
Eitan Friedman City University of New York
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania

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