Shigehisa Hirose

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• Amino acid

Shigehisa Hirose mostly deals with Biochemistry, Molecular biology, Endocrinology, Internal medicine and Peptide sequence. Shigehisa Hirose frequently studies issues relating to Cell biology and Biochemistry. The various areas that he examines in his Molecular biology study include Amino acid and Complementary DNA, Gene expression, Gene, Recombinant DNA.

Shigehisa Hirose combines subjects such as Receptor, Basement membrane, Alkaline phosphatase and Osteoblast with his study of Endocrinology. His Receptor study incorporates themes from Messenger RNA and Atrial natriuretic peptide. The Peptide sequence study combines topics in areas such as Elafin and G protein-coupled receptor.

His most cited work include:

• Cloning and sequence analysis of cDNA for human renin precursor (221 citations)
• The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core (169 citations)
• Enhanced Expression of Endothelial Oxidized Low-Density Lipoprotein Receptor (LOX-1) in Hypertensive Rats (142 citations)

What are the main themes of his work throughout his whole career to date?

Biochemistry, Endocrinology, Internal medicine, Molecular biology and Receptor are his primary areas of study. His work deals with themes such as Gene expression, Osteoblast and Cell biology, which intersect with Endocrinology. His Internal medicine study combines topics in areas such as Osteocalcin and Northern blot.

His Molecular biology research includes themes of Amino acid and Complementary DNA, cDNA library, Peptide sequence, Messenger RNA. His study in cDNA library is interdisciplinary in nature, drawing from both Open reading frame, Molecular cloning and Nucleic acid sequence. In the field of Receptor, his study on Endothelin receptor and Affinity labeling overlaps with subjects such as NPR2 and NPR1.

He most often published in these fields:

• Biochemistry (37.91%)
• Endocrinology (34.60%)
• Internal medicine (34.60%)

What were the highlights of his more recent work (between 2009-2021)?

• Molecular biology (33.65%)
• Cell biology (16.59%)
• Biochemistry (37.91%)

In recent papers he was focusing on the following fields of study:

Shigehisa Hirose mainly investigates Molecular biology, Cell biology, Biochemistry, Secretion and Apical membrane. His Molecular biology research is multidisciplinary, incorporating elements of Inflammation, Bronchoalveolar lavage, Lung, Kidney and Ubiquitin ligase. His Lung research focuses on Monocyte and how it connects with Receptor.

His biological study spans a wide range of topics, including Internal medicine and Endocrinology. His Endocrinology research incorporates themes from Calcitonin gene-related peptide and Ligand. Biochemistry is frequently linked to Sodium–hydrogen antiporter in his study.

Between 2009 and 2021, his most popular works were:

• Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways. (53 citations)
• Close Association of Carbonic Anhydrase (CA2a and CA15a), Na+/H+ Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in Zebrafish Ionocytes Responsible for Na+ Uptake (43 citations)
• Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D (43 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• Amino acid

His primary scientific interests are in Molecular biology, Cell biology, Biochemistry, Extracellular and Ubiquitin ligase. His work in the fields of Molecular biology, such as Glycoprotein, overlaps with other areas such as Pulmonary Surfactant-Associated Protein D. The Cell biology study combines topics in areas such as Endocrinology, Toxicology, Gene expression and Mutant.

His work on Apical membrane as part of general Biochemistry study is frequently connected to Germination, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His Extracellular research includes elements of Surfactant homeostasis, Pulmonary alveolar proteinosis, Immunoprecipitation, Secretion and Pulmonary surfactant. In Ubiquitin ligase, Shigehisa Hirose works on issues like Transmembrane protein, which are connected to Protease, Endoplasmic-reticulum-associated protein degradation, Deubiquitination, Ubiquitin and Deubiquitinating enzyme.