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Tatsuya Sawamura

Tatsuya Sawamura

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
27831
World Ranking
1856
National Ranking
105

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Tatsuya Sawamura is affiliated with Shinshu University in Japan and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research primarily focuses on topics related to atherosclerosis and cardiovascular diseases, exploring the molecular and cellular mechanisms underlying these conditions.

Their work covers several main topics, including:

  • Atherosclerosis and Cardiovascular Diseases
  • Inflammatory mediators and NSAID effects
  • Lipoproteins and Cardiovascular Health
  • Receptor Mechanisms and Signaling
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Cardiovascular Disease and Adiposity

Sawamura's research also spans several subfields, such as Immunology, Molecular Biology, Surgery, Pharmacology, and Cardiology and Cardiovascular Medicine. Publications have appeared frequently in journals including Scientific Reports, Atherosclerosis, Hypertension Research, eLife, and Frontiers in Cardiovascular Medicine.

Frequent collaborators in their research include Akemi Kakino, Chu-Huang Chen, Kōichi Yamamoto, Yoichi Nozato, and Yoichi Takami.

Notable recent papers authored or co-authored by Sawamura include:

  • Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease, 2020, European Heart Journal
  • LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) Deletion Has Protective Effects on Stroke in the Genetic Background of Stroke-Prone Spontaneously Hypertensive Rat, 2020, Stroke
  • The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor, 2021, iScience
  • Detection of a High Ratio of Soluble to Membrane-Bound LOX-1 in Aspirated Coronary Thrombi From Patients With ST-Segment-Elevation Myocardial Infarction, 2020, Journal of the American Heart Association
  • The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men, 2020, Atherosclerosis

Best Publications

  • An endothelial receptor for oxidized low-density lipoprotein

    Tatsuya Sawamura;Noriaki Kume;Takuma Aoyama;Hideaki Moriwaki

  • Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation

    Yves Delneste;Giovanni Magistrelli;Jean-François Gauchat;Jean-François Haeuw

  • Oxidized Low Density Lipoprotein (ox-LDL) Binding to ox-LDL Receptor-1 in Endothelial Cells Induces the Activation of NF-κB through an Increased Production of Intracellular Reactive Oxygen Species

    Luciano Cominacini;Anna Fratta Pasini;Ulisse Garbin;Anna Davoli

  • Effects of Rho-Associated Protein Kinase Inhibitor Y-27632 on Intraocular Pressure and Outflow Facility

    Megumi Honjo;Hidenobu Tanihara;Masaru Inatani;Noriaki Kido

  • Expression of Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 in Human Atherosclerotic Lesions

    Hiroharu Kataoka;Noriaki Kume;Susumu Miyamoto;Manabu Minami

  • Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet

    Jawahar L. Mehta;Nobuhito Sanada;Chang Ping Hu;Jiawei Chen

  • LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.

    Mingyi Chen;Tomoh Masaki;Tatsuya Sawamura

  • The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide

    Luciano Cominacini;Anna Rigoni;Anna Fratta Pasini;Ulisse Garbin

  • Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

    Kozo Oka;Tatsuya Sawamura;Ken-ichiro Kikuta;Shigekazu Itokawa

  • Inducible Expression of Lectin-like Oxidized LDL Receptor-1 in Vascular Endothelial Cells

    Noriaki Kume;Takatoshi Murase;Hideaki Moriwaki;Takuma Aoyama

  • Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation

    D. Y. Li;Y. C. Zhang;M. I. Philips;T. Sawamura

  • A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

    Mercy R. PrabhuDas;Cynthia L. Baldwin;Paul L. Bollyky;Dawn M.E. Bowdish

  • Angiotensin II Induces LOX-1, the Human Endothelial Receptor for Oxidized Low-Density Lipoprotein

    Henning Morawietz;Uwe Rueckschloss;Bernd Niemann;Nicole Duerrschmidt

  • Fluid Shear Stress Transcriptionally Induces Lectin-like Oxidized LDL Receptor-1 in Vascular Endothelial Cells

    Takatoshi Murase;Noriaki Kume;Risa Korenaga;Joji Ando

  • OXIDIZED LOW-DENSITY LIPOPROTEIN INDUCES ENDOTHELIAL PROGENITOR CELL SENESCENCE, LEADING TO CELLULAR DYSFUNCTION

    Toshio Imanishi;Takuzo Hano;Tatsuya Sawamura;Ichiro Nishio

  • LOX-1 Mediates Oxidized Low-Density Lipoprotein-Induced Expression of Matrix Metalloproteinases in Human Coronary Artery Endothelial Cells

    Dayuan Li;Ling Liu;Hongjiang Chen;Tatsuya Sawamura

  • Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1

    Dayuan Li;Hongjiang Chen;Francesco Romeo;Tatsuya Sawamura

  • Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.

    Yasushi Ishigaki;Hideki Katagiri;Junhong Gao;Tetsuya Yamada

  • Structure-activity relationships of endothelin: importance of the C-terminal moiety.

    Sadao Kimura;Yoshitoshi Kasuya;Tatsuya Sawamura;Osamu Shinmi

  • A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

    Mercy R. PrabhuDas;Cynthia L. Baldwin;Paul L. Bollyky;Dawn M. E. Bowdish

Frequent Co-Authors

Tomoh Masaki
Tomoh Masaki Kyoto University
Jawahar L. Mehta
Jawahar L. Mehta University of Arkansas for Medical Sciences
Toru Kita
Toru Kita Kyoto University
Noriaki Kume
Noriaki Kume Kobe Gakuin University
Sadao Kimura
Sadao Kimura Chiba University
Masashi Yanagisawa
Masashi Yanagisawa University of Tsukuba
Tomonori Okamura
Tomonori Okamura Keio University
Katsutoshi Goto
Katsutoshi Goto University of Tsukuba
Shigetake Sasayama
Shigetake Sasayama Kyoto University
Claudio Napoli
Claudio Napoli University of Campania "Luigi Vanvitelli"

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