Stuart K. Calderwood mainly investigates Heat shock protein, Cell biology, Molecular biology, Hsp70 and Heat shock factor. His Heat shock protein study incorporates themes from Carcinogenesis and Cancer research. His studies examine the connections between Cell biology and genetics, as well as such issues in Receptor, with regards to Immune system.
He interconnects Tumor necrosis factor alpha, Gene expression, Untranslated region and Camptothecin in the investigation of issues within Molecular biology. The concepts of his Heat shock factor study are interwoven with issues in Cell culture, HSF1, HSPA12A, Transcription factor and HSPA1B. His work deals with themes such as Cancer and Immunology, which intersect with Hsp27.
Stuart K. Calderwood focuses on Cell biology, Heat shock protein, HSF1, Cancer research and Molecular biology. His Cell biology research is multidisciplinary, relying on both Receptor and Biochemistry. Heat shock protein is closely attributed to Cancer cell in his work.
His study in HSF1 is interdisciplinary in nature, drawing from both Protein kinase A, Psychological repression, Transcription factor, Promoter and Regulation of gene expression. His studies deal with areas such as Carcinogenesis, Cancer, Prostate cancer, Tumor progression and CDC37 as well as Cancer research. His Molecular biology study combines topics in areas such as Cell culture, HSPA4 and Gene expression.
Stuart K. Calderwood spends much of his time researching Cell biology, Cancer research, Heat shock protein, Cancer cell and Transcription factor. His work on Extracellular and Signal transduction as part of general Cell biology study is frequently linked to Scavenger receptor, bridging the gap between disciplines. The study incorporates disciplines such as Epithelial–mesenchymal transition, Carcinogenesis, Cancer, Tumor progression and CDC37 in addition to Cancer research.
In his study, which falls under the umbrella issue of Carcinogenesis, Antiparkinson drug is strongly linked to Metastasis. His Heat shock protein study frequently links to related topics such as Intracellular. His Cancer cell study also includes fields such as
His scientific interests lie mostly in Cell biology, Cancer research, Heat shock protein, Transcription factor and HSF1. His work carried out in the field of Cell biology brings together such families of science as Cell culture, Autocrine signalling and Antigen. His Cancer research study integrates concerns from other disciplines, such as Exosome, Epithelial–mesenchymal transition, Cetuximab, Epidermal growth factor receptor and Extracellular vesicle.
His research on Heat shock protein focuses in particular on Hsp90. His Transcription factor research incorporates elements of Heat shock factor, RNA polymerase II, Transcription and Molecular biology. His biological study spans a wide range of topics, including Regulation of gene expression and Heat shock.
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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
Alexzander Asea;Stine-Kathrein Kraeft;Evelyn A. Kurt-Jones;Evelyn A. Kurt-Jones;Mary Ann Stevenson.
Nature Medicine (2000)
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.
Alexzander Asea;Michael Rehli;Edith Kabingu;Jason A. Boch.
Journal of Biological Chemistry (2002)
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
Daniel R. Ciocca;Stuart K. Calderwood;Stuart K. Calderwood.
Cell Stress & Chaperones (2005)
Heat shock proteins in cancer: chaperones of tumorigenesis
Stuart K. Calderwood;Stuart K. Calderwood;Abdul Khaleque;Douglas B. Sawyer;Daniel R. Ciocca.
Trends in Biochemical Sciences (2006)
Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1
Boyang Chu;Fabrice Soncin;Brendan D. Price;Mary Ann Stevenson.
Journal of Biological Chemistry (1996)
Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen
S T Palayoor;M Y Youmell;S K Calderwood;C N Coleman.
Extracellular heat shock proteins in cell signaling.
Stuart K. Calderwood;Salamatu S. Mambula;Philip J. Gray;Jimmy R. Theriault.
FEBS Letters (2007)
Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes
Salamatu S. Mambula;Stuart K. Calderwood.
Journal of Immunology (2006)
Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells
Elfriede Noessner;Robert Gastpar;Valeria Milani;Anna Brandl.
Journal of Immunology (2002)
The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review
Stuart K. Calderwood;Ayesha Murshid;Thomas Prince.
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