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D-Index & Metrics

Biology and Biochemistry

D-Index
122
Citations
73355
World Ranking
573
National Ranking
363

Medicine

D-Index
122
Citations
73391
World Ranking
3416
National Ranking
1881

Overview

Paul Dent is a researcher affiliated with Virginia Commonwealth University in the United States, specializing in biochemistry, genetics, molecular biology, and medicine. Their work spans several subfields including molecular biology, epidemiology, cell biology, oncology, and immunology. The primary focus of their research encompasses diverse topics such as autophagy in disease and therapy, histone deacetylase inhibitors research, endoplasmic reticulum stress and disease, PI3K/AKT/mTOR signaling in cancer, Hippo pathway signaling and YAP/TAZ, protein degradation and inhibitors, and cutaneous lymphoproliferative disorders research.

Paul Dent has been involved in multiple publications, contributing to several journals and venues. Frequent publication venues include:

  • Frontiers in Oncology
  • Anti-Cancer Drugs
  • Oncotarget
  • Biochemical Pharmacology
  • Journal of Cellular Physiology

They have collaborated extensively with several coauthors, notably:

  • Laurence Booth
  • Andrew Poklepovic
  • Jane L. Roberts
  • Cameron West
  • Daniel D. Von Hoff

Selected recent papers authored or coauthored by Paul Dent include:

  • "(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo", 2020, Journal of Cellular Physiology
  • "Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling", 2020, Journal of Cellular Physiology
  • "AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication", 2020, Biochemical Pharmacology
  • "The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells", 2020, Cellular Signalling
  • "GZ17-6.02 initiates DNA damage causing autophagosome-dependent HDAC degradation resulting in enhanced anti-PD1 checkpoint inhibitory antibody efficacy", 2020, Journal of Cellular Physiology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

    Jie Wu;Paul Dent;Tomas Jelinek;Alan Wolfman

  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

    Paul Dent;Wayne Haser;Timothy A. J. Haystead;Leigh Ann Vincent

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • MAPK pathways in radiation responses.

    Paul Dent;Adly Yacoub;Paul B Fisher;Michael P Hagan

  • Bile acids as regulatory molecules.

    Phillip B. Hylemon;Huiping Zhou;William M. Pandak;Shunlin Ren

  • The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

    P. Dent;A. Lavoinne;S. Nakielny;F. B. Caudwell

  • Stress and radiation-induced activation of multiple intracellular signaling pathways.

    Paul Dent;Adly Yacoub;Joseph Contessa;Ruben Caron

  • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.

    R K Schmidt-Ullrich;R B Mikkelsen;P Dent;D G Todd

  • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

    Shuang Chen;Yun Dai;Hisashi Harada;Paul Dent

  • Radiation-induced Release of Transforming Growth Factor α Activates the Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase Pathway in Carcinoma Cells, Leading to Increased Proliferation and Protection from Radiation-induced Cell Death

    Paul Dent;Dean B. Reardon;Jong Sung Park;Geoffrey Bowers

  • mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK

    Devanand Sarkar;Zao-Zhong Su;Irina V. Lebedeva;Moira Sauane

  • The role of cell signalling in the crosstalk between autophagy and apoptosis

    Laurence A. Booth;Seyedmehrad Tavallai;Hossein A. Hamed;Nichola Cruickshanks

  • Signal transduction and cellular radiation responses

    Rupert K. Schmidt-Ullrich;Paul Dent;Steven Grant;Ross B. Mikkelsen

  • Radiation-induced cell signaling: inside-out and outside-in

    Kristoffer Valerie;Adly Yacoub;Michael P. Hagan;David T. Curiel

  • Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway

    Seema Gupta;R. Todd Stravitz;Paul Dent;Phillip B. Hylemon

  • Differentiation therapy of human cancer: basic science and clinical applications

    Magdalena Leszczyniecka;Terry Roberts;Paul Dent;Steven Grant

  • Apoptosis Induced by the Kinase Inhibitor BAY 43-9006 in Human Leukemia Cells Involves Down-regulation of Mcl-1 through Inhibition of Translation

    Mohamed Rahmani;Eric Maynard Davis;Cheryl Bauer;Paul Dent

Frequent Co-Authors

Steven Grant
Steven Grant Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Adly Yacoub
Adly Yacoub Virginia Commonwealth University
Devanand Sarkar
Devanand Sarkar Virginia Commonwealth University
David T. Curiel
David T. Curiel Washington University in St. Louis
Mohamed Rahmani
Mohamed Rahmani Khalifa University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Kristoffer Valerie
Kristoffer Valerie Virginia Commonwealth University
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Pankaj Gupta
Pankaj Gupta Post Graduate Institute of Medical Education and Research

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