World's Best Scientists 2026 revealed!
Jean-Charles Lambert

Jean-Charles Lambert

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Genetics
France
2024
Award Badge
Genetics and Molecular Biology
France
2024

D-Index & Metrics

Genetics

D-Index
90
Citations
45792
World Ranking
1062
National Ranking
35

Medicine

D-Index
90
Citations
46644
World Ranking
11973
National Ranking
372

Research.com Recognitions

  • 2024 - Research.com Genetics in France Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award

Overview

Jean-Charles Lambert is affiliated with Inserm in France and has contributed extensively to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans multiple subfields including Molecular Biology, Genetics, Physiology, Astronomy and Astrophysics, and Neurology.

The scientist's research topics cover a broad range of areas, notably:

  • Alzheimer's disease research and treatments
  • Genetic Associations and Epidemiology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Bioinformatics and Genomic Networks
  • Astronomy and Astrophysical Research
  • Cellular transport and secretion

Jean-Charles Lambert has published in various frequent venues, with notable contributions to:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Astronomy and Astrophysics
  • Molecular Psychiatry
  • arXiv (Cornell University)

Among their recent papers are:

  • Neuroinflammation in Alzheimer disease, 2024, Nature reviews. Immunology
  • Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains, 2021, npj Aging and Mechanisms of Disease
  • Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease, 2023, JAMA Network Open
  • Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts, 2020, The Lancet Rheumatology
  • Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease, 2022, JAMA Neurology

The scientist regularly collaborates with several co-authors including Alfredo Ramírez, Philippe Amouyel, Benjamin Grenier-Boley, Devrim Kilinc, and Céline Bellenguez.

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Genome-wide association study indentifies variants at CLU and CR1 associated with Alzheimer’s disease

    J Lambert;S Heath;G Even;D Campion

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Genome-wide analysis of genetic loci associated with Alzheimer disease.

    Sudha Seshadri;Annette L. Fitzpatrick;M Arfan Ikram;Anita L. DeStefano

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • APOE and Alzheimer disease: a major gene with semi-dominant inheritance

    E Genin;D Hannequin;D Wallon;K Sleegers

  • Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

    Demetrius M. Maraganore;Mariza De Andrade;Alexis Elbaz;Matthew J. Farrer

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Cristian Pattaro;Alexander Teumer;Mathias Gorski;Audrey Y. Chu

  • Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

    J Chapuis;F Hansmannel;M Gistelinck;A Mounier

  • Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

    G. Davies;N. Armstrong;J. C. Bis;J. Bressler

  • Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

    L.A. Robak;L.A. Robak;I.E. Jansen;I.E. Jansen;J van Rooij;A.G. Uitterlinden

  • Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

    Suzanne Lesage;Valérie Drouet;Elisa Majounie;Vincent Deramecourt

  • Common polygenic variation enhances risk prediction for Alzheimer's disease.

    Valentina Escott-Price;Rebecca Sims;Christian Bannister;Denise Harold

  • Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

    A. Beilina;I. N. Rudenko;A. Kaganovich;L. Civiero

  • A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk

    Ute Dreses-Werringloer;Jean Charles Lambert;Valérie Vingtdeux;Haitian Zhao

  • A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

    Kuan Lin Huang;Edoardo Marcora;Anna A. Pimenova;Antonio F. Di Narzo

  • Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study

    Isabelle Le Ber;Agnès Camuzat;Didier Hannequin;Florence Pasquier

  • High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

    Pottier C;Hannequin D;Coutant S;Rovelet-Lecrux A

Frequent Co-Authors

Philippe Amouyel
Philippe Amouyel University of Lille
Benjamin Grenier-Boley
Benjamin Grenier-Boley Institut Pasteur
Vincent Chouraki
Vincent Chouraki University of Lille
Céline Bellenguez
Céline Bellenguez Institut Pasteur
Florence Pasquier
Florence Pasquier University of Lille
Jean-François Dartigues
Jean-François Dartigues University of Bordeaux
Sudha Seshadri
Sudha Seshadri The University of Texas Health Science Center at San Antonio
Christophe Tzourio
Christophe Tzourio University of Bordeaux

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