World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Best Female Scientists
2025

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Best Female Scientists

D-Index
168
Citations
135022
World Ranking
68
National Ranking
40

Best Scientists

D-Index
168
Citations
135022
World Ranking
936
National Ranking
554

Genetics

D-Index
163
Citations
133513
World Ranking
86
National Ranking
43

Medicine

D-Index
171
Citations
143565
World Ranking
501
National Ranking
299

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Best Female Scientists Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2016 - Member of the National Academy of Medicine (NAM)
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1994 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1993 - Sedgwick Memorial Medal, American Public Health Association
  • 1993 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Overview

Alison Goate is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on Alzheimer's disease and related neurological conditions, encompassing a wide range of studies in medicine, biochemistry, genetics, molecular biology, and neuroscience.

Their work spans multiple main fields of study: medicine, biochemistry, genetics and molecular biology, and neuroscience. These areas are further refined into subfields such as molecular biology, physiology, neurology, genetics, and psychiatry and mental health. This comprehensive approach supports research on neurodegenerative diseases and cognitive impairments.

The primary topics covered by Alison Goate's research include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Dementia and cognitive impairment research
  • Genetic associations and epidemiology
  • Bioinformatics and genomic networks
  • Epigenetics and DNA methylation
  • Functional brain connectivity studies

Alison Goate has contributed to a substantial number of publications in frequent venues such as:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Psychiatry
  • Brain

Notable recent papers authored or co-authored by Alison Goate include:

  • "A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease" (2020) published in Nature Medicine
  • "Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study" (2020) published in Nature Communications
  • "A large-scale genome-wide association study meta-analysis of cannabis use disorder" (2020) published in The Lancet Psychiatry
  • "A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease" (2021) published in Nature Medicine
  • "The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease" (2020) published in Nature

Frequent collaborators in Alison Goate's research include Carlos Cruchaga, Randall J. Bateman, Eric McDade, Celeste M. Karch, and Tammie L.S. Benzinger.

The scientist has received several awards, including:

  • Member of the National Academy of Medicine (NAM), 2016
  • Fellow of the American Association for the Advancement of Science (AAAS), 2012
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease, 1994
  • Sedgwick Memorial Medal, American Public Health Association, 1993
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology, 1993

Best Publications

  • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

    Alison Goate;Marie-Christine Chartier-Harlin;Mike Mullan;Jeremy Brown

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

    Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan

  • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

    M. Hutton;C. L. Lendon;P. Rizzu;M. Baker

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

    Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Javier Simón-Sánchez;Claudia Schulte;Jose M Bras;Jose M Bras;Manu Sharma

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Mike A Nalls;Nathan Pankratz;Christina M. Lill;Chuong B. Do

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Alzheimer’s Disease: The Challenge of the Second Century

    David M. Holtzman;John C. Morris;Alison M. Goate

  • Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

    Marie Christine Chartier-Harlin;Fiona Crawford;Henry Houlden;Andrew Warren

  • Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

    Antonio F. Pardiñas;Peter Holmans;Andrew J. Pocklington;Valentina Escott-Price

  • Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

    Joseph M. Castellano;Jungsu Kim;Floy R. Stewart;Hong Jiang

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

    Celeste M. Karch;Alison M. Goate

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

John C. Morris
John C. Morris Washington University in St. Louis
Tatiana Foroud
Tatiana Foroud Indiana University
Howard J. Edenberg
Howard J. Edenberg Indiana University
John I. Nurnberger
John I. Nurnberger Indiana University
Laura J. Bierut
Laura J. Bierut Washington University in St. Louis
Bernice Porjesz
Bernice Porjesz SUNY Downstate Medical Center
John Hardy
John Hardy University College London
Anne M. Fagan
Anne M. Fagan Washington University in St. Louis
John P. Rice
John P. Rice Washington University in St. Louis
Marc A. Schuckit
Marc A. Schuckit University of California, San Diego

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