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2025
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Medicine
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2026

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Best Scientists

D-Index
205
Citations
153410
World Ranking
243
National Ranking
162

Neuroscience

D-Index
212
Citations
164908
World Ranking
20
National Ranking
14

Medicine

D-Index
212
Citations
164966
World Ranking
123
National Ranking
83

Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2017 - Fellow, National Academy of Inventors
  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2008 - Member of the National Academy of Medicine (NAM)
  • 2006 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 2003 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 2003 - Sedgwick Memorial Medal, American Public Health Association

Overview

David M. Holtzman is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on the fields of Medicine and Neuroscience, with significant contributions in subfields such as Physiology, Neurology, Psychiatry and Mental Health, Molecular Biology, and Cognitive Neuroscience.

Key topics of their scientific work include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Tryptophan and brain disorders
  • Functional Brain Connectivity Studies
  • Inflammation biomarkers and pathways
  • Neurological Disease Mechanisms and Treatments

Holtzman has contributed to multiple publication venues, with notable frequency in:

  • Alzheimer s & Dementia
  • Annals of Clinical and Translational Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuron
  • Molecular Neurodegeneration

The list of frequent co-authors associated with their work includes:

  • John C. Morris
  • Randall J. Bateman
  • Tammie L.S. Benzinger
  • Carlos Cruchaga
  • Jason D. Ulrich

Recent significant publications by or involving Holtzman include:

  • "Hallmarks of neurodegenerative diseases," 2023, Cell
  • "Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy," 2023, Nature
  • "Alzheimer disease," 2021, Nature Reviews Disease Primers
  • "Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy," 2021, Nature
  • "Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease," 2020, Nature Medicine

Throughout their career, Holtzman has been recognized with several awards, including:

  • Fellow, National Academy of Inventors (2017)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2014)
  • Member of the National Academy of Medicine (NAM) (2008)
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease (2006)
  • Sedgwick Memorial Medal, American Public Health Association (2003)
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology (2003)

Best Publications

  • NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

    Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo

  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

    Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan

  • The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease

    Marilyn S. Albert;Steven T. DeKosky;Dennis Dickson;Bruno Dubois

  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

    Susanne Krasemann;Susanne Krasemann;Charlotte Madore;Ron Cialic;Caroline Baufeld

  • Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.

    Justin M. Long;David M. Holtzman

  • National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards

    Vladimir Hachinski;Costantino Iadecola;Ron C. Petersen;Monique M. Breteler

  • Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

    Bruno Dubois;Harald Hampel;Harald Hampel;Howard H. Feldman;Philip Scheltens

  • The Role of Apolipoprotein E in Alzheimer's Disease

    Jungsu Kim;Jacob M. Basak;David M. Holtzman

  • TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

    Yaming Wang;Yaming Wang;Marina Cella;Kaitlin Mallinson;Jason D. Ulrich

  • Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

    Jae Eun Kang;Miranda M. Lim;Randall J. Bateman;James J. Lee

  • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

    Masayoshi Shibata;Shinya Yamada;S. Ram Kumar;Miguel Calero

  • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

    Ronald B. DeMattos;Kelly R. Bales;David J. Cummins;Jean-Cosme Dodart

  • Alzheimer’s Disease: The Challenge of the Second Century

    David M. Holtzman;John C. Morris;Alison M. Goate

  • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

    Anne M. Fagan;Mark A. Mintun;Robert H. Mach;Sang-Yoon Lee

  • Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

    Steven E. Arnold;Zoe Arvanitakis;Shannon L. Macauley-Rambach;Aaron M. Koenig

  • Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

    John R. Cirrito;Kelvin A. Yamada;Mary Beth Finn;Robert S. Sloviter

  • Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

    Joseph M. Castellano;Jungsu Kim;Floy R. Stewart;Hong Jiang

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    Robert D. Bell;Ethan A. Winkler;Itender Singh;Abhay P. Sagare

  • Biomarker Modeling of Alzheimer’s Disease

    Clifford R Jr. Jack;David M. Holtzman

  • Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

    Jean Cosme Dodart;Kelly R. Bales;Kimberley S. Gannon;Stephen J. Greene

  • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

    Melanie Meyer-Luehmann;Tara L. Spires-Jones;Claudia Prada;Monica Garcia-Alloza

Frequent Co-Authors

Anne M. Fagan
Anne M. Fagan Washington University in St. Louis
John C. Morris
John C. Morris Washington University in St. Louis
Tammie L.S. Benzinger
Tammie L.S. Benzinger Washington University in St. Louis
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Randall J. Bateman
Randall J. Bateman Washington University in St. Louis
Hong Jiang
Hong Jiang Nanjing Tech University
John S. K. Kauwe
John S. K. Kauwe Brigham Young University
Mark A. Mintun
Mark A. Mintun University of Pennsylvania
Beau M. Ances
Beau M. Ances Washington University in St. Louis
Guojun Bu
Guojun Bu Hong Kong University of Science and Technology

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