D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 165 Citations 95,472 479 World Ranking 227 National Ranking 152
Best Scientists D-index 182 Citations 111,794 729 World Ranking 395 National Ranking 263

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Alzheimer's disease

David M. Holtzman focuses on Alzheimer's disease, Internal medicine, Endocrinology, Apolipoprotein E and Neuroscience. His studies deal with areas such as Dementia, Cerebrospinal fluid and Immunology as well as Alzheimer's disease. The study incorporates disciplines such as Clusterin and Oncology in addition to Internal medicine.

His Endocrinology research incorporates themes from In vivo, Genetically modified mouse and Amyloid precursor protein. His studies in Apolipoprotein E integrate themes in fields like Receptor, LRP1, Transgene and Lipoprotein. His Neuroscience research is multidisciplinary, incorporating perspectives in Neurotrophin and Programmed cell death.

His most cited work include:

  • NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease (2145 citations)
  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease (2062 citations)
  • The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease (1942 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Alzheimer's disease, Internal medicine, Disease, Pathology and Endocrinology. David M. Holtzman usually deals with Alzheimer's disease and limits it to topics linked to Amyloid and P3 peptide. His work on Internal medicine is being expanded to include thematically relevant topics such as Oncology.

His Disease study which covers Neuroscience that intersects with Neurodegeneration. His research on Pathology frequently links to adjacent areas such as In vivo. In his research, Microglia is intimately related to Cell biology, which falls under the overarching field of Apolipoprotein E.

He most often published in these fields:

  • Alzheimer's disease (33.01%)
  • Internal medicine (33.01%)
  • Disease (23.78%)

What were the highlights of his more recent work (between 2017-2021)?

  • Apolipoprotein E (21.68%)
  • Disease (23.78%)
  • Internal medicine (33.01%)

In recent papers he was focusing on the following fields of study:

David M. Holtzman mainly investigates Apolipoprotein E, Disease, Internal medicine, Alzheimer's disease and Dementia. His Apolipoprotein E research incorporates elements of Neurodegeneration, TREM2, Microglia, Cell biology and Amyloid. His research investigates the connection between Disease and topics such as Neuroscience that intersect with problems in Senile plaques and Neuropathology.

His biological study spans a wide range of topics, including Endocrinology and Oncology. David M. Holtzman has researched Alzheimer's disease in several fields, including Amyloid β, Bioinformatics, Pathogenesis, Gastroenterology and Amyloidosis. His research integrates issues of Microbiome and Down syndrome in his study of Dementia.

Between 2017 and 2021, his most popular works were:

  • NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease (2145 citations)
  • Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums (345 citations)
  • Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. (319 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Alzheimer's disease

His primary scientific interests are in Alzheimer's disease, Dementia, Apolipoprotein E, Amyloid and Internal medicine. Alzheimer's disease is a subfield of Disease that David M. Holtzman investigates. His study looks at the intersection of Dementia and topics like Neurodegeneration with Tau protein.

His work deals with themes such as Transgene, TREM2, Microglia, Allele and Innate immune system, which intersect with Apolipoprotein E. The concepts of his Amyloid study are interwoven with issues in Receptor and Positron emission tomography, Neuroscience, Isolated brain. The various areas that David M. Holtzman examines in his Internal medicine study include White matter, Endocrinology and Calpain.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease

Marilyn S. Albert;Steven T. DeKosky;Dennis Dickson;Bruno Dubois.
FOCUS (2013)

3022 Citations

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan.
The New England Journal of Medicine (2012)

2742 Citations

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo.
Alzheimers & Dementia (2018)

2575 Citations

National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards

Vladimir Hachinski;Costantino Iadecola;Ron C. Petersen;Monique M. Breteler.
Stroke (2006)

1923 Citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

Ronald B. DeMattos;Kelly R. Bales;David J. Cummins;Jean-Cosme Dodart.
Proceedings of the National Academy of Sciences of the United States of America (2001)

1608 Citations

The Role of Apolipoprotein E in Alzheimer's Disease

Jungsu Kim;Jacob M. Basak;David M. Holtzman.
Neuron (2009)

1473 Citations

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

Masayoshi Shibata;Shinya Yamada;S. Ram Kumar;Miguel Calero.
Journal of Clinical Investigation (2000)

1429 Citations

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

Anne M Fagan;Mark A Mintun;Robert H Mach;Sang-Yoon Lee.
Annals of Neurology (2006)

1304 Citations

Alzheimer’s Disease: The Challenge of the Second Century

David M. Holtzman;John C. Morris;Alison M. Goate.
Science Translational Medicine (2011)

1254 Citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Jean Cosme Dodart;Kelly R. Bales;Kimberley S. Gannon;Stephen J. Greene.
Nature Neuroscience (2002)

1159 Citations

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Best Scientists Citing David M. Holtzman

Kaj Blennow

Kaj Blennow

University of Gothenburg

Publications: 815

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Henrik Zetterberg

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Philip Scheltens

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Vrije Universiteit Amsterdam

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William J. Jagust

William J. Jagust

Helen Wills Neuroscience Institute

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John Q. Trojanowski

John Q. Trojanowski

University of Pennsylvania

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Oskar Hansson

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Bradley T. Hyman

Bradley T. Hyman

Harvard University

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Ronald C. Petersen

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Mayo Clinic

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Pieter Jelle Visser

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Victor L. Villemagne

Victor L. Villemagne

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