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Best Scientists

D-Index
205
Citations
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World Ranking
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162

Neuroscience

D-Index
212
Citations
164908
World Ranking
20
National Ranking
14

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D-Index
212
Citations
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David M. Holtzman publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where David M. Holtzman sits on this spectrum.

38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientists 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38 publications 887+

This scientist: 729 publications — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

David M. Holtzman D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where David M. Holtzman sits on this spectrum.

30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30 D-Index 163+

This scientist: 212 D-Index — 100th percentile

100% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2017 - Fellow, National Academy of Inventors
  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2008 - Member of the National Academy of Medicine (NAM)
  • 2006 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 2003 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 2003 - Sedgwick Memorial Medal, American Public Health Association

Overview

David M. Holtzman is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on the fields of Medicine and Neuroscience, with significant contributions in subfields such as Physiology, Neurology, Psychiatry and Mental Health, Molecular Biology, and Cognitive Neuroscience.

Key topics of their scientific work include:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Tryptophan and brain disorders
  • Functional Brain Connectivity Studies
  • Inflammation biomarkers and pathways
  • Neurological Disease Mechanisms and Treatments

Holtzman has contributed to multiple publication venues, with notable frequency in:

  • Alzheimer s & Dementia
  • Annals of Clinical and Translational Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuron
  • Molecular Neurodegeneration

The list of frequent co-authors associated with their work includes:

  • John C. Morris
  • Randall J. Bateman
  • Tammie L.S. Benzinger
  • Carlos Cruchaga
  • Jason D. Ulrich

Recent significant publications by or involving Holtzman include:

  • "Hallmarks of neurodegenerative diseases," 2023, Cell
  • "Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy," 2023, Nature
  • "Alzheimer disease," 2021, Nature Reviews Disease Primers
  • "Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy," 2021, Nature
  • "Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease," 2020, Nature Medicine

Throughout their career, Holtzman has been recognized with several awards, including:

  • Fellow, National Academy of Inventors (2017)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2014)
  • Member of the National Academy of Medicine (NAM) (2008)
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease (2006)
  • Sedgwick Memorial Medal, American Public Health Association (2003)
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology (2003)

Best Publications

  • NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

    Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo

  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

    Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan

  • The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease

    Marilyn S. Albert;Steven T. DeKosky;Dennis Dickson;Bruno Dubois

  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

    Susanne Krasemann;Susanne Krasemann;Charlotte Madore;Ron Cialic;Caroline Baufeld

  • Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.

    Justin M. Long;David M. Holtzman

  • National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards

    Vladimir Hachinski;Costantino Iadecola;Ron C. Petersen;Monique M. Breteler

  • Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

    Bruno Dubois;Harald Hampel;Harald Hampel;Howard H. Feldman;Philip Scheltens

  • The Role of Apolipoprotein E in Alzheimer's Disease

    Jungsu Kim;Jacob M. Basak;David M. Holtzman

  • TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

    Yaming Wang;Yaming Wang;Marina Cella;Kaitlin Mallinson;Jason D. Ulrich

  • Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

    Jae Eun Kang;Miranda M. Lim;Randall J. Bateman;James J. Lee

  • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

    Masayoshi Shibata;Shinya Yamada;S. Ram Kumar;Miguel Calero

  • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

    Ronald B. DeMattos;Kelly R. Bales;David J. Cummins;Jean-Cosme Dodart

  • Alzheimer’s Disease: The Challenge of the Second Century

    David M. Holtzman;John C. Morris;Alison M. Goate

  • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

    Anne M. Fagan;Mark A. Mintun;Robert H. Mach;Sang-Yoon Lee

  • Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

    Steven E. Arnold;Zoe Arvanitakis;Shannon L. Macauley-Rambach;Aaron M. Koenig

  • Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

    John R. Cirrito;Kelvin A. Yamada;Mary Beth Finn;Robert S. Sloviter

  • Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

    Joseph M. Castellano;Jungsu Kim;Floy R. Stewart;Hong Jiang

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    Robert D. Bell;Ethan A. Winkler;Itender Singh;Abhay P. Sagare

  • Biomarker Modeling of Alzheimer’s Disease

    Clifford R Jr. Jack;David M. Holtzman

  • Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

    Jean Cosme Dodart;Kelly R. Bales;Kimberley S. Gannon;Stephen J. Greene

  • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

    Melanie Meyer-Luehmann;Tara L. Spires-Jones;Claudia Prada;Monica Garcia-Alloza

Frequent Co-Authors

Anne M. Fagan
Anne M. Fagan Washington University in St. Louis
John C. Morris
John C. Morris Washington University in St. Louis
Tammie L.S. Benzinger
Tammie L.S. Benzinger Washington University in St. Louis
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Randall J. Bateman
Randall J. Bateman Washington University in St. Louis
Hong Jiang
Hong Jiang Nanjing Tech University
John S. K. Kauwe
John S. K. Kauwe Brigham Young University
Mark A. Mintun
Mark A. Mintun University of Pennsylvania
Beau M. Ances
Beau M. Ances Washington University in St. Louis
Guojun Bu
Guojun Bu Hong Kong University of Science and Technology

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Related Online Degrees & Career Pathways

If you are considering a degree in neuroscience, it’s helpful to explore related fields and alternative options that can also lead to rewarding careers. For students seeking strong earning potential, there are several most profitable degrees to consider, including those in healthcare, engineering, or computer science—fields that often overlap with neuroscience research.

Many students are concerned about tuition costs. Fortunately, there are online colleges that offer financial aid, making education more accessible and affordable. Additionally, if you prefer a shorter or more focused path, there are short certificate programs that pay well, especially in medical technology, data science, or mental health services.

For those seeking a quicker entry into the workforce or a less rigorous academic load, consider reviewing the easiest online degrees. These alternatives can still provide solid foundational skills and open doors to entry-level positions in related fields.

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