World's Best Scientists 2026 revealed!
Clifford R. Jack

Clifford R. Jack

Award Badge
Best Scientists
2025
Award Badge
Neuroscience
USA
2026

D-Index & Metrics

Best Scientists

D-Index
182
Citations
155650
World Ranking
568
National Ranking
362

Neuroscience

D-Index
189
Citations
171053
World Ranking
42
National Ranking
29

Medicine

D-Index
189
Citations
171173
World Ranking
263
National Ranking
176

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2008 - Sedgwick Memorial Medal, American Public Health Association
  • 2008 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Clifford R. Jack is affiliated with the Mayo Clinic in the United States and has made substantial contributions to medical research, especially in the study of neurodegenerative diseases. Their research primarily focuses on the diagnosis, staging, and imaging of Alzheimer's disease and related dementias.

The scientist has published extensively in the field of Medicine, with a significant body of work addressing Psychiatry and Mental Health, Physiology, Neurology, Radiology, Nuclear Medicine and Imaging, and Cognitive Neuroscience. Their research topics prominently cover Dementia and Cognitive Impairment Research, Alzheimer's disease research and treatments, Functional Brain Connectivity Studies, Advanced Neuroimaging Techniques and Applications, Parkinson's Disease Mechanisms and Treatments, Neurological Disease Mechanisms and Treatments, and Advanced MRI Techniques and Applications.

Some of the recent papers by Clifford R. Jack include:

  • "Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup," 2024, Alzheimer s & Dementia
  • "Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias," 2020, The Lancet Neurology
  • "Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease," 2020, Nature Communications
  • "Performance of plasma phosphorylated tau 181 and 217 in the community," 2022, Nature Medicine
  • "Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline," 2022, Nature Medicine

Frequent collaborators include Ronald C. Petersen, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, and Matthew L. Senjem. These co-authors have worked closely with Clifford R. Jack on numerous projects, reflecting a collaborative approach to advancing understanding in their shared fields of interest.

Their publications are commonly featured in venues such as Alzheimer s & Dementia, Neurology, Brain Communications, JAMA Neurology, and bioRxiv (Cold Spring Harbor Laboratory), indicating an active engagement with high-impact journals relevant to neurology and dementia research.

Among the recognitions received, Clifford R. Jack was awarded the Sedgwick Memorial Medal by the American Public Health Association in 2008 and the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases by the American Academy of Neurology, also in 2008. They are a member of the Association of American Physicians.

Best Publications

  • The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

    Guy M. McKhann;Guy M. McKhann;David S. Knopman;Howard Chertkow;Bradley T. Hyman

  • NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

    Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo

  • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Reisa A. Sperling;Paul S. Aisen;Laurel A. Beckett;David A. Bennett

  • Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.

    B. Winblad;K. Palmer;Miia Kivipelto;V. Jelic

  • The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods.

    Clifford R. Jack;Matt A. Bernstein;Nick C. Fox;Paul Thompson

  • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Clifford R. Jack;Marilyn S. Albert;David S. Knopman;Guy M. McKhann

  • The clinical use of structural MRI in Alzheimer disease

    Giovanni B. Frisoni;Nick C. Fox;Clifford R. Jack;Philip Scheltens

  • Alzheimer's Disease Neuroimaging Initiative

    Susanne G. Mueller;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

    Clifford R. Jack;Ronald C. Petersen;Yue Cheng Xu;Peter C. O'Brien

  • A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

    Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo

  • Mild cognitive impairment: ten years later.

    Ronald Carl Petersen;Rosebud O Roberts;David S Knopman;Bradley F Boeve

  • Automatic classification of MR scans in Alzheimer's disease

    Stefan Klöppel;Cynthia M. Stonnington;Carlton Chu;Bogdan Draganski

  • Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

    Peter T. Nelson;Dennis W. Dickson;John Q. Trojanowski;Clifford R. Jack

  • The Alzheimer's disease neuroimaging initiative

    Susanne G. Mueller;Michael W. Weiner;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.

    Clifford R. Jack Jr.;Val J. Lowe;Stephen D Weigand;Heather J. Wiste

  • Biomarker Modeling of Alzheimer’s Disease

    Clifford R Jr. Jack;David M. Holtzman

  • Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

    Clifford R. Jack;R. C. Petersen;Y. Xu;P. C. O'Brien

  • MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease.

    Clifford R. Jack;Ronald C. Petersen;Peter C. O'Brien;Eric G. Tangalos

  • Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.

    Michael Grundman;Ronald C. Petersen;Steven H. Ferris;Ronald G. Thomas

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Introduction to the recommendations from the National Institute on Aging and the Alzheimer's Association workgroup on diagnostic guidelines for Alzheimer's disease

    Clifford R. Jack;Marilyn S. Albert;David S. Knopman;Guy M. McKhann

Frequent Co-Authors

Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
David S. Knopman
David S. Knopman Mayo Clinic
Val J. Lowe
Val J. Lowe Mayo Clinic
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
Kejal Kantarci
Kejal Kantarci Mayo Clinic
Mary M. Machulda
Mary M. Machulda Mayo Clinic

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